Tuesday, February 17, 2026 2/17/2026

Contribution of ASC Dynamics to Survival within the Bone Marrow

Award Number: F32HL149155
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 08/01/2019
PERIOD OF PERFORMANCE END DATE: 07/31/2021

Group Awards By:

View Award Description

Contribution of ASC Dynamics to Survival within the Bone Marrow - Abstract Humoral immunity is the basis of all worldwide vaccination campaigns and has been one of the most effective public health advancements to curtail disease. Critical to humoral immunity is the development and long term survival of long-lived antibody secreting cells (LLASCs). LLASCs reside in the bone marrow (BM) and can confer protection towards specific pathogens for a lifetime. However, some vaccinations can only induce temporary immunity (months to a few years). Therefore, understanding how LLASCs survive can yield insight into improving vaccines. ASCs are thought to dock into a static, supportive niche where they can receive pro survival signals (IL-6, APRIL) and produce antibody. Studies of the ASC-niche have implicated a number of cell types in supporting ASCs due to their ability to produce pro survival cytokines and their close proximity to ASCs in static, confocal images. However, these studies do not address how ASCs dynamically interact within their niche nor how ASCs (either newly generated or LLASCs) compete for the limited resources provided by the niche. Therefore, how dynamics affect ASC competition, survival, and factor into longevity is not known. This project seeks to understand how the dynamics of ASCs affects their competition and survival in the BM. In this project I will assess how ASCs interact within the BM environment. I will combine intravital two photon microscopy with novel and classical functional studies to study the factors that promote dynamic ASC interactions within their BM niche. I will determine the factors that contribute to ASC dynamics and dissect how the dynamics affects long-term survival and retention of ASCs in the BM. This work will yield new insights into how resident cells of the BM interact with their specific niches and to a better understanding of the BM ASC niche.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = -$1 )
2023	2020	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Blood Diseases and Resources Research	000	2	11/23/2022	NON-COMPETING CONTINUATION	-$1
														Subtotal = -$1

Issue Date FY: 2022 ( Subtotal = -$67,868 )
2022	2021	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Blood Diseases and Resources Research	000	3	11/30/2021	NON-COMPETING CONTINUATION	-$65,610
2022	2020	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Blood Diseases and Resources Research	001	2	1/10/2022	NON-COMPETING CONTINUATION	-$2,258
														Subtotal = -$67,868

Issue Date FY: 2021 ( Subtotal = $65,610 )
2021	2021	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Blood Diseases and Resources Research	000	3	7/29/2021	NON-COMPETING CONTINUATION	$65,610
														Subtotal = $65,610

Issue Date FY: 2020 ( Subtotal = $65,310 )
2020	2020	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Blood Diseases and Resources Research	000	2	6/19/2020	NON-COMPETING CONTINUATION	$65,310
														Subtotal = $65,310

Issue Date FY: 2019 ( Subtotal = $61,226 )
2019	2019	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Blood Diseases and Resources Research	001	1	7/31/2019	NEW	$0
2019	2019	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Blood Diseases and Resources Research	000	1	7/31/2019	NEW	$61,226
														Subtotal = $61,226

Grand Total All Awards = $124,277

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Contribution of ASC Dynamics to Survival within the Bone Marrow

Award Number: F32HL149155

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 08/01/2019

PERIOD OF PERFORMANCE END DATE: 07/31/2021

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer