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Maturation of inhibitory circuits in the gustatory cortex and expression of taste preference

Award Number: F32DC018485
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 01/20/2020
PERIOD OF PERFORMANCE END DATE: 01/19/2023

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Maturation of inhibitory circuits in the gustatory cortex and expression of taste preference - Project Summary As animals transition from relying on their mother’s milk to foraging and consuming foods, they experience an abundance of new tastes. These experiences regulate taste preference later in life through a process which likely relies on plasticity in neural circuits associated with taste and feeding. The gustatory cortex (GC) is involved in processing tastes and is required for taste-motivated behaviors as well as learning about tastes. How these early experiences affect the development of taste preferences or the maturation of GC circuits has not been the subject of investigation. Maturation of inhibitory circuits in other primary sensory systems is a hallmark of postnatal development. This proposal will investigate the role of taste experience in shaping later taste preference, whether a postnatal sensitive window exists in which experience shapes taste preference, and the cellular- and circuit-level GC physiology which is sensitive to taste experience, with a focus on inhibition. The first part of the proposal will examine how taste preferences mature from juvenile to adult ages. The role of taste experience at the time of weaning versus in adulthood in modulating taste preference will also be examined. Maturation of inhibitory networks within the GC will be examined by quantifying parvalbumin-positive inhibitory neurons, their connection strength onto pyramidal neurons, and the total spontaneous GABAergic synaptic transmission onto pyramidal neurons in the GC from pre- and post-weaning ages. The role of taste experience on inhibitory maturation will also be examined. Finally, the relationship between the maturation of inhibition and the development of taste preferences will be assessed by chemical disruption of stabilizing proteins on parvalbumin-positive neurons. These studies will elucidate the necessity of a mature inhibitory circuit in GC for the behavioral expression of taste preference as well as whether a sensitive window exists in which experience shapes taste preference. While mechanisms underlying learning about the value or physical cues associated with tastes has been investigated in adulthood, the postnatal mechanisms leading to such a refined circuit have not been described. The results of these studies will indicate the role of early food experiences in determining taste-based choices throughout life.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$12,944 )
2024	2022	THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK	W5510 FRANKS MELVILLE MEMORIAL LIBRARY	STONY BROOK	NY	11794	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	000	3	12/28/2023	NON-COMPETING CONTINUATION	-$12,944
														Subtotal = -$12,944

Issue Date FY: 2022 ( Subtotal = $81,050 )
2022	2022	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	WEST 5510 FRANKS MELVILLE MEMORIAL LIBRARY	STONY BROOK	NY	11794	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	002	3	5/19/2022	NON-COMPETING CONTINUATION	$2
2022	2022	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	WEST 5510 FRANKS MELVILLE MEMORIAL LIBRARY	STONY BROOK	NY	11794	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	000	3	12/22/2021	NON-COMPETING CONTINUATION	$79,642
2022	2022	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	WEST 5510 FRANKS MELVILLE MEMORIAL LIBRARY	STONY BROOK	NY	11794	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	001	3	4/25/2022	NON-COMPETING CONTINUATION	$1,406
														Subtotal = $81,050

Issue Date FY: 2021 ( Subtotal = $77,142 )
2021	2021	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	WEST 5510 FRANKS MELVILLE MEMORIAL LIBRARY	STONY BROOK	NY	11794	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	001	2	2/5/2021	NON-COMPETING CONTINUATION	$1,284
2021	2021	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	WEST 5510 FRANKS MELVILLE MEMORIAL LIBRARY	STONY BROOK	NY	11794	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	000	2	12/30/2020	NON-COMPETING CONTINUATION	$75,858
														Subtotal = $77,142

Issue Date FY: 2020 ( Subtotal = $73,650 )
2020	2020	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	WEST 5510 FRANKS MELVILLE MEMORIAL LIBRARY	STONY BROOK	NY	11794	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	001	1	12/9/2019	NEW	$0
2020	2020	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	WEST 5510 FRANKS MELVILLE MEMORIAL LIBRARY	STONY BROOK	NY	11794	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	000	1	12/9/2019	NEW	$69,950
2020	2020	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	WEST 5510 FRANKS MELVILLE MEMORIAL LIBRARY	STONY BROOK	NY	11794	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	002	1	2/11/2020	NEW	$3,700
														Subtotal = $73,650

Grand Total All Awards = $218,898

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Maturation of inhibitory circuits in the gustatory cortex and expression of taste preference

Award Number: F32DC018485

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 01/20/2020

PERIOD OF PERFORMANCE END DATE: 01/19/2023

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