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Deciphering the coupled roles of protein secretion and metabolism in cancer using an integrative omics approach

Award Number: F32CA220848
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 02/01/2018
PERIOD OF PERFORMANCE END DATE: 01/31/2021

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Deciphering the coupled roles of protein secretion and metabolism in cancer using an integrative omics approach - PROJECT SUMMARY Despite extensive and ongoing efforts to improve our ability to detect and treat cancer, it remains a leading cause of death worldwide, and incidence is only expected to continue rising. Recent advancements in high- throughput omic profiling technologies have facilitated a more thorough understanding of tumor physiology, enabling rapid quantification of molecular-level features with sufficient detail and breadth to begin unraveling the underlying mechanisms that drive malignant transformation. However, the full potential of omics techniques cannot be accessed without the use of systems biology approaches that optimize the extraction of biologically meaningful information from these increasingly large and complex datasets. Using an integrative approach to map omics data to biomolecular networks, such as genome-scale metabolic models, protein-protein interaction networks, and transcription factor signaling networks, constitutes a more effective approach, and has been demonstrated to successfully elucidate novel and medically important features from omics datasets. We propose to employ integrative omics analyses to determine how changes in human metabolic and protein secretory processes drive malignant transformation, and how the tumor phenotype shapes these processes in return. Despite extensive efforts to characterize the individual components of the protein secretory pathway and their role in diseases such as cancer, studies treating these components as a connected, interacting system are lacking. The proposed work seeks to develop a more comprehensive and quantitative understanding of the protein secretion pathway and its interactions with the metabolic network in the context of cancer by integrating multiple layers of top-down omics datasets with bottom-up biological networks. Results obtained from these studies will lead to new candidate biomarkers for use in patient stratification and disease diagnosis, reveal novel mechanistic information on cancer and tumor physiology, and provide new tools with which human omics datasets can be processed. Approaches and tools developed for these efforts will have broad application to other diseases and biological systems, and will help drive the shift in healthcare toward personalized medicine.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2022 ( Subtotal = -$15,050 )
2022	2019	CHALMERS TEKNISKA HOGSKOLA AKTIEBOLAG	CHALMERSPLATSEN 4	GOTEBORG				SWE	Cancer Research Manpower	000	2	4/22/2022	NON-COMPETING CONTINUATION	-$10,850
2022	2019	REDACTED DUE TO PII		GOTEBORG				SWE	Cancer Research Manpower	001	2	4/22/2022	NON-COMPETING CONTINUATION	$0
2022	2017	CHALMERS TEKNISKA HOGSKOLA AKTIEBOLAG	CHALMERSPLATSEN 4	GOTEBORG				SWE	Cancer Research Manpower	002	1	6/29/2022	NEW	-$4,200
														Subtotal = -$15,050

Issue Date FY: 2020 ( Subtotal = -$4,408 )
2020	2019	REDACTED DUE TO PII		GOTEBORG		41296		SWE	Cancer Research Manpower	000	2	2/18/2020	NON-COMPETING CONTINUATION	-$4,408
														Subtotal = -$4,408

Issue Date FY: 2019 ( Subtotal = $63,746 )
2019	2019	CHALMERS TEKNISKA HOGSKOLA AB	CHALMERSPLATSEN 4	GOTEBORG		41296		SWE	Cancer Research Manpower	001	2	1/31/2019	NON-COMPETING CONTINUATION	$10,850
2019	2019	REDACTED DUE TO PII		GOTEBORG		41296		SWE	Cancer Research Manpower	000	2	1/30/2019	NON-COMPETING CONTINUATION	$52,896
														Subtotal = $63,746

Issue Date FY: 2018 ( Subtotal = $0 )
2018	2017	CHALMERS TEKNISKA HOGSKOLA AB	CHALMERSPLATSEN 4	GOTEBORG		41296		SWE	Cancer Research Manpower	003	1	11/29/2017	NEW	$0
2018	2017	CHALMERS TEKNISKA HOGSKOLA AB	CHALMERSPLATSEN 4	GOTEBORG		41296		SWE	Cancer Research Manpower	002	1	11/29/2017	NEW	$0
														Subtotal = $0

Issue Date FY: 2017 ( Subtotal = $4,200 )
2017	2017	CHALMERS TEKNISKA HOGSKOLA AB	CHALMERSPLATSEN 4	GOTEBORG		41296		SWE	Cancer Research Manpower	001	1	8/22/2017	NEW	$4,200
														Subtotal = $4,200

Grand Total All Awards = $48,488

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Deciphering the coupled roles of protein secretion and metabolism in cancer using an integrative omics approach

Award Number: F32CA220848

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 02/01/2018

PERIOD OF PERFORMANCE END DATE: 01/31/2021

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