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MECHANISTIC STUDIES OF NF-KB INHIBITION OF MYOGENESIS

Award Number: F32AR054244
ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 09/01/2006
PERIOD OF PERFORMANCE END DATE: 01/31/2009

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MECHANISTIC STUDIES OF NF-KB INHIBITION OF MYOGENESIS - DESCRIPTION (provided by applicant): NF-kappaB (NF-kB) is a transcription factor which plays a pivotal role in the regulation of cell growth, differentiation and cellular survival. Accumulating evidence suggest that NF-kB is involved in several skeletal muscle disorders although its mechanism of action is not well defined. In this proposal we attempt to gain insight into the roles of NF-kB in muscle diseases by understanding how NF-kB functions in skeletal myogenesis at a basic level. Recent studies have revealed that NF-kB plays an inhibitory role in skeletal myogenesis through multiple mechanisms. Based on our preliminary results we hypothesized that NF-kB inhibition of myogenesis could occur through direct or indirect repression of troponin gene expression. To test this hypothesis we propose to perform the following aims: 1) determine whether inhibition of troponin gene expression is mediated by direct NF-kB binding; 2) investigate whether NF-kB regulates troponin gene expression indirectly through YY1; 3)perform a genome-wide search of the YY1 and NF-kB target genes. Completion of these aims will provide us new mechnistic insights into how NF-kB function in skeletal myogenesis and advance our understanding of how it participates in the skeletal muscle disorders.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2013 ( Subtotal = -$145 )
2013	2008	OHIO STATE UNIVERSITY, RESEARCH FOUNDATION	1960 KENNY ROAD	COLUMBUS	OH	43210	FRANKLIN	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	3	8/29/2013	NON-COMPETING CONTINUATION	-$145
														Subtotal = -$145

Issue Date FY: 2011 ( Subtotal = -$30,203 )
2011	2008	OHIO STATE UNIVERSITY, RESEARCH FOUNDATION	1960 KENNY ROAD	COLUMBUS	OH	43210	FRANKLIN	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	3	3/11/2011	NON-COMPETING CONTINUATION	-$30,203
														Subtotal = -$30,203

Issue Date FY: 2008 ( Subtotal = $52,898 )
2008	2008	OHIO STATE UNIVERSITY, RESEARCH FOUNDATION	1960 KENNY ROAD	COLUMBUS	OH	43210	FRANKLIN	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	3	8/1/2008	NON-COMPETING CONTINUATION	$52,898
														Subtotal = $52,898

Issue Date FY: 2007 ( Subtotal = $51,278 )
2007	2007	OHIO STATE UNIVERSITY, RESEARCH FOUNDATION	1960 KENNY ROAD	COLUMBUS	OH	43210	FRANKLIN	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	2	8/7/2007	NON-COMPETING CONTINUATION	$51,278
														Subtotal = $51,278

Issue Date FY: 2006 ( Subtotal = $48,796 )
2006	2006	OHIO STATE UNIVERSITY, RESEARCH FOUNDATION	1960 KENNY ROAD	COLUMBUS	OH	43210	FRANKLIN	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	1	8/22/2006	NEW	$48,796
														Subtotal = $48,796

Grand Total All Awards = $122,624

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MECHANISTIC STUDIES OF NF-KB INHIBITION OF MYOGENESIS

Award Number: F32AR054244

ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 09/01/2006

PERIOD OF PERFORMANCE END DATE: 01/31/2009

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