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A clinical neuroscience approach to understand stress coping in alcohol use disorder

Award Number: F32AA031425
ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 02/01/2024
PERIOD OF PERFORMANCE END DATE: 06/30/2024

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A clinical neuroscience approach to understand stress coping in alcohol use disorder - ABSTRACT Alcohol use disorder (AUD) is a chronic, relapsing brain disorder. It is well established that stress motivates alcohol use and triggers relapse in individuals with AUD; however, the neural mechanisms that underlie this association are not clear. Preclinical studies have shown that chronic alcohol and chronic stress impact the brain’s stress systems in a way that results in deficits in flexible, adaptive stress coping. These deficits can perpetuate a cycle of enduring stress conditions, and ultimately drive progression of AUD. The vast majority of the literature examining chronic stress and its effects on brain function in AUD has yet to be translated from preclinical to human clinical samples. Furthermore, clinical studies examining chronic stress and its association with brain function in AUD are limited by the nature and quality of chronic stress measures, which primarily rely on self-report questionnaires. To advance the translational impact of the science of the stress neurocircuitry in AUD, it is critical that clinical studies implement methods to objectively measure chronic stress. This F32 NRSA will objectively assess chronic stress and examine dynamic functional connectivity within the brain’s stress coping system, using fMRI, in a clinical sample with AUD (n=32) and matched controls (n=32). Additionally, this F32 will foster the applicant’s development as independent clinical and translational neuroscientist with a focus on the intersection of stress and AUD. This application will draw on resources from the Sponsors’ (Drs. Lara Ray and Erica Grodin) R21 study investigating the effect of stress on decision-making in AUD by adding complimentary, non-overlapping scientific aims and outcome measures. The UCLA Life Stress Interview will be used to objectively assess the psychological experience of chronic stress. Resting state fMRI will be used to examine dynamic functional connectivity within the brain’s stress coping network. The ventromedial prefrontal cortex (vmPFC) is recognized as a key locus in a resilient stress coping network, and recent studies have suggested that dynamic changes in vmPFC activation during acute stress signals resilient coping. The applicant will extend this work by measuring dynamic vmPFC functional connectivity to characterize temporal variability within the network. The applicant will integrate these psychological and neural levels of analysis to examine the effects of chronic stress on temporal variability, or flexibility, within the brain’s stress coping system in AUD versus controls. Aim 1 tests the hypothesis that individuals with AUD will exhibit greater chronic stress compared with controls. Aim 2 tests the hypothesis that individuals with AUD will exhibit diminished temporal variability (flexibility) in vmPFC resting state functional connectivity compared with controls. Aim 3 tests the hypothesis that chronic stress will be associated with decreased flexibility in vmPFC resting state functional connectivity, and that AUD will moderate this relationship. The proposed study represents important steps in: 1) translating preclinical science on the stress neurocircuitry in AUD; and 2) the applicant’s scientific development and maturity as an independent clinical alcohol researcher with an interest in the role of stress in AUD.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$42,440 )
2025	2024	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Alcohol Research Programs	001	1	4/24/2025	NEW	-$407
2025	2024	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Alcohol Research Programs	000	1	3/7/2025	NEW	-$42,033
														Subtotal = -$42,440

Issue Date FY: 2024 ( Subtotal = $73,828 )
2024	2024	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Alcohol Research Programs	002	1	5/1/2024	NEW	$4,748
2024	2024	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Alcohol Research Programs	000	1	1/24/2024	NEW	$69,080
2024	2024	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Alcohol Research Programs	001	1	1/24/2024	NEW	$0
														Subtotal = $73,828

Grand Total All Awards = $31,388

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A clinical neuroscience approach to understand stress coping in alcohol use disorder

Award Number: F32AA031425

ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 02/01/2024

PERIOD OF PERFORMANCE END DATE: 06/30/2024

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