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Balancing excitatory and inhibitory LHb signaling underlying stress

Award Number: F31MH125569
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 08/01/2021
PERIOD OF PERFORMANCE END DATE: 07/31/2023

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Balancing excitatory and inhibitory LHb signaling underlying stress - PROJECT SUMMARY Over 40 millions individuals in the United States are impacted by stress related disorders, that are highly comorbid with mood disorders such as anxiety and depression. Cognitive behavioral therapy and decades of animal literature has established that reinstating a sense of autonomy or behavioral control over a stressful experience can buffer many of the psychological and behavioral impacts of stress and reduce the severity of depressive and anxiety-like behaviors. However, it is not entirely known which neurochemical pathways are recruited by behavioral control to facilitate or hinder this stress resilience. Understanding how neurochemical signaling dynamics change following stress (with and without behavioral control) and identifying which projections are responsible for these changes is a foundational step in developing therapeutics for stress related disorders. To address this, I will implement a rodent model of stressor controllability to 1) identify how neurochemical signaling dynamics change following behavioral control, in a brain region highly implicated in mediating the effects of stress and 2) manipulate neurochemical-specific projections to this region that are implicated in these changes to identify their involvement in stressor controllability. The goal of the proposed project is to determine how behavioral control impacts discrete neurochemical signaling specifically between the lateral habenula (LHb) and the ventral tegmental area (VTA), two interacting brain regions that play causal roles in both stress and motivated behavior. The successful completion of these aims will address mechanistically how behavioral control influences LHb neurochemical signaling and test the hypothesis that the VTA glutamate → LHb pathway contributes to behavioral deficits following stress experience in the absence of behavioral control.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$960 )
2024	2022	THE REGENTS OF THE UNIVERSITY OF COLORADO	3100 MARINE ST	BOULDER	CO	80309	BOULDER	USA	Mental Health Research Grants	000	2	5/22/2024	NON-COMPETING CONTINUATION	-$960
														Subtotal = -$960

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2022	REGENTS OF THE UNIVERSITY OF COLORADO, THE	3100 MARINE ST STE 481 572 UCB	BOULDER	CO	80309	BOULDER	USA	Mental Health Research Grants	000	2	8/15/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $39,252 )
2022	2022	REGENTS OF THE UNIVERSITY OF COLORADO, THE	3100 MARINE ST STE 481 572 UCB	BOULDER	CO	80309	BOULDER	USA	Mental Health Research Grants	000	2	7/19/2022	NON-COMPETING CONTINUATION	$39,252
														Subtotal = $39,252

Issue Date FY: 2021 ( Subtotal = $38,349 )
2021	2021	REGENTS OF THE UNIVERSITY OF COLORADO, THE	3100 MARINE ST STE 481 572 UCB	BOULDER	CO	80309	BOULDER	USA	Mental Health Research Grants	000	1	2/19/2021	NEW	$38,349
2021	2021	REGENTS OF THE UNIVERSITY OF COLORADO, THE	3100 MARINE ST STE 481 572 UCB	BOULDER	CO	80309	BOULDER	USA	Mental Health Research Grants	001	1	2/19/2021	NEW	$0
														Subtotal = $38,349

Grand Total All Awards = $76,641

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Balancing excitatory and inhibitory LHb signaling underlying stress

Award Number: F31MH125569

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 08/01/2021

PERIOD OF PERFORMANCE END DATE: 07/31/2023

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