Tuesday, February 17, 2026 2/17/2026

Role of shox2 in zebrafish otic neuron development

Award Number: F31DC016239
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 01/09/2017
PERIOD OF PERFORMANCE END DATE: 01/08/2020

Group Awards By:

View Award Description

Role of shox2 in zebrafish otic neuron development - Project Abstract Hearing loss is a highly heterogeneous genetic disorder that makes diagnosis and treatment of patients challenging. Mutations in genes that result in syndromic hearing loss are often involved in the development of hair cells and auditory neurons. The discovery and study of genetic factors that contribute to the development of the inner ear will clarify the molecular etiology behind hearing loss and allow development of strategies to treat hearing loss. The short stature homeobox domain 2 (SHOX2) gene was identified as a candidate transcription factor involved in early development of auditory neuron through bioinformatic analysis. To better understand and recapitulate the role of human SHOX2 in inner ear development, zebrafish was chosen as a model organism. During embryonic development, zebrafish shox2 is expressed in the otic placode and later in the cranial ganglia which includes the statoacoustic neurons. I hypothesize that shox2 determines the cell fate of otic progenitors that give rise to neurons. I will evaluate auditory and vestibular behavior of zebrafish after morpholino knockdown of shox2. I will determine shox2 expression in otic progenitors by performing immunofluorescence in situ hybridization on zebrafish reporter lines that mark the otic progenitor pools. Furthermore, I will determine how shox2 knockdown affects the number of cells within each progenitor population. Finally, I will perform lineage tracing by generating and utilizing a tamoxifen inducible shox2-p2A–CreERT2 to mark progeny that arise from shox2 cells. These aims will clarify the role of shox2 in establishment of otic progenitor cells and potentially add this gene to a repertoire of factors responsible for hair cell and otic neuron development.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2019 ( Subtotal = $35,724 )
2019	2019	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	3 RUTGERS PLZA	NEW BRUNSWICK	NJ	08901	MIDDLESEX	USA	Research Related to Deafness and Communication Disorders	000	3	1/8/2019	NON-COMPETING CONTINUATION	$35,724
														Subtotal = $35,724

Issue Date FY: 2018 ( Subtotal = $35,232 )
2018	2018	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	3 RUTGERS PLZA	NEW BRUNSWICK	NJ	08901	MIDDLESEX	USA	Research Related to Deafness and Communication Disorders	000	2	12/28/2017	NON-COMPETING CONTINUATION	$34,752
2018	2018	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	3 RUTGERS PLZA	NEW BRUNSWICK	NJ	08901	MIDDLESEX	USA	Research Related to Deafness and Communication Disorders	001	2	5/10/2018	NON-COMPETING CONTINUATION	$480
														Subtotal = $35,232

Issue Date FY: 2017 ( Subtotal = $34,752 )
2017	2017	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	3 RUTGERS PLZA	NEW BRUNSWICK	NJ	08901	MIDDLESEX	USA	Research Related to Deafness and Communication Disorders	002	1	6/27/2017	NEW	$468
2017	2017	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	3 RUTGERS PLZA	NEW BRUNSWICK	NJ	08901	MIDDLESEX	USA	Research Related to Deafness and Communication Disorders	000	1	1/9/2017	NEW	$34,284
2017	2017	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	3 RUTGERS PLZA	NEW BRUNSWICK	NJ	08901	MIDDLESEX	USA	Research Related to Deafness and Communication Disorders	001	1	1/9/2017	NEW	$0
														Subtotal = $34,752

Grand Total All Awards = $105,708

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Role of shox2 in zebrafish otic neuron development

Award Number: F31DC016239

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 01/09/2017

PERIOD OF PERFORMANCE END DATE: 01/08/2020

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer