Wednesday, February 18, 2026 2/18/2026

The role of mitochondrial ATP production in liver failure

Award Number: F30DK137407
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 02/01/2024
PERIOD OF PERFORMANCE END DATE: 01/31/2028

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The role of mitochondrial ATP production in liver failure - PROJECT SUMMARY/ABSTRACT Mitochondrial energetic dysfunction is implicated in many common human diseases, including conditions impacting the liver such as nonalcoholic fatty liver disease (NAFLD), nonalcoholic steatohepatitis (NASH) and liver failure. The precise consequences of loss of mitochondrial energetics in the mammalian liver are largely unknown. To date our understanding of the roles of mitochondrial complex V (mCV), or ATP synthase, has arisen primarily from in vitro cultured cells or yeast studies. These seminal results revealed structural and functional insights into mCV’s role, but are unable to clearly delineate the physiologic effects of mitochondrial energy dysfunction. Our lab has developed a new mouse model that conditionally deletes a core subunit of mCV and ablates the ATP synthesis activity of the mitochondria. This model will enable us to study pure mitochondrial energy dysfunction in any organ system, and in particular this proposal aims to determine effects of mitochondrial energy dysfunction in the adult murine liver. To accomplish this, a combination of isotope tracing mass spectrometry, nuclear magnetic resonance, specialized mitochondrial respiratory assays, electron microscopy, next generation sequencing and mouse physiology studies will be used. The specific aims of this proposal intend to 1) understand the mitochondrial structural and functional consequences of mCV disruption in liver and 2) determine the contributions of mitochondrial ATP to liver and whole body homeostasis. The findings of this proposal will provide insights into basic mitochondrial biology and the pathophysiology of common liver diseases.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $50,406 )
2026	2026	THE UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	3	1/26/2026	NON-COMPETING CONTINUATION	$49,842
2026	2025	THE UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	2	1/16/2026	NON-COMPETING CONTINUATION	$564
														Subtotal = $50,406

Issue Date FY: 2025 ( Subtotal = $40,049 )
2025	2025	THE UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	2	1/17/2025	NON-COMPETING CONTINUATION	$40,049
														Subtotal = $40,049

Issue Date FY: 2024 ( Subtotal = $40,049 )
2024	2024	THE UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	1	5/2/2024	NEW	$1,280
2024	2024	THE UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	1	1/30/2024	NEW	$0
2024	2024	UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER, THE	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	1/30/2024	NEW	$38,769
														Subtotal = $40,049

Grand Total All Awards = $130,504

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The role of mitochondrial ATP production in liver failure

Award Number: F30DK137407

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 02/01/2024

PERIOD OF PERFORMANCE END DATE: 01/31/2028

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