The goal of the Advancing Communication and Care in Safety-net Systems to Include Black and Latinx Equity (ACCESSIBLE) project is to conduct research that advances primary care equity for Black and Latinx persons with disabilities. Research in health and health care disparities experienced by persons with disabilities suggests multi-level, systemic issues perpetuate ableism. Due to potential compounding effects of the intersectionality of ableism and racism, understanding and addressing the systemic barriers that affect both is needed. We propose to elucidate barriers and potential solutions at three levels, patient, provider/staff, and clinic, as well as contribute to the understanding of how these levels intersect. The objectives are to (1) understand patient and caregiver perspectives on the effects of intersectionality of ableism and racism in health care through qualitative focus groups, (2) identify structural conditions that contribute to ableism and racism within primary care through qualitative case studies at Federally Qualified Health Centers (FQHCs), and (3) engage a national stakeholder panel to develop a framework for addressing structural racism and ableism in the primary care setting. ACCESSIBLE outputs include: best practices for engaging Black and Latinx persons with disabilities in research, a framework for addressing structural racism and ableism in the primary care setting. We anticipate that the results will collectively be used in a future trial of a multi-level intervention aimed at improving care for Black and Latinx patients with disabilities.