Wednesday, February 18, 2026 2/18/2026

A Randomized Trial of I-InTERACT Preterm: A Novel Approach to Reducing Disability in Children Born Very Preterm

Award Number: 90IFRE0075
ORGANIZATION: NATIONAL INSTITUTE ON DISABILITY, INDEPENDENT LIVING, AND REHABILITATION RESEARCH
OPDIV: ACL
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: OTHER
PERIOD OF PERFORMANCE START DATE: 09/01/2023
PERIOD OF PERFORMANCE END DATE: 08/31/2026

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A Randomized Trial of I-InTERACT Preterm: A Novel Approach to Reducing Disability in Children Born Very Preterm - Very preterm birth (VPT), defined as 32 weeks gestational age or less, is a significant and growing public health concern that disproportionately affects various communities, where some infants are more likely to be affected. VPT children are at high risk for cognitive, behavioral and academic impairments that persist into adolescence and adulthood. Yet, few, if any, tailored interventions have been developed to promote responsive parenting beyond three years of age, when early intervention services end and demands for child self-regulation and further parental supports increase. Recognizing that (1) VPT children are at high risk of behavioral and academic challenges, with concomitant effects on caregiver stress, and that (2) caregiver stress and parenting behaviors directly impact child behavior, the goal of this intervention efficacy research is to examine the efficacy of I-InTERACT Preterm (I-2P) , an online intervention designed to promote responsive parenting and reduce parental distress, relative to access to internet resources on prematurity and parenting (Internet Resource Comparison; IRC). The intervention delivers psychoeducation about VPT neurocognitive development, teaches positive parenting skills, and promote parental stress management and self-care. Our objectives are to (1) refine and enhance I-2P based on prior pilot testing and parent advisory board feedback, (2) evaluate efficacy, both immediately post treatment and three months later, using a randomized control trial design, and (3) examine moderating factors such a household income and baseline functioning. The anticipated outcomes are that caregivers who receive I-2P will demonstrate more responsive parenting and report fewer child behavior problems at follow-up than caregivers in the IRC. The expected product is an empirically supported, cost-effective intervention that would reduce long-term behavior problems in young children born very preterm.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2024	CHILDRENS HOSPITAL MEDICAL CENTER	3333 BURNET AVE	CINCINNATI	OH	45229	HAMILTON	USA	ACL National Institute on Disability, Independent Living, and Rehabilitation Research	01	3	1/26/2026	OTHER REVISION	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $200,000 )
2025	2025	CHILDRENS HOSPITAL MEDICAL CENTER	3333 BURNET AVE	CINCINNATI	OH	45229	HAMILTON	USA	ACL National Institute on Disability, Independent Living, and Rehabilitation Research	00	3	9/17/2025	NON-COMPETING CONTINUATION	$200,000
2025	2024	CHILDRENS HOSPITAL MEDICAL CENTER	3333 BURNET AVE	CINCINNATI	OH	45229	HAMILTON	USA	ACL National Institute on Disability, Independent Living, and Rehabilitation Research	01	2	2/6/2025	OTHER REVISION	$0
2025	2023	CHILDRENS HOSPITAL MEDICAL CENTER	3333 BURNET AVE	CINCINNATI	OH	45229	HAMILTON	USA	ACL National Institute on Disability, Independent Living, and Rehabilitation Research	01	2	2/6/2025	OTHER REVISION	$0
														Subtotal = $200,000

Issue Date FY: 2024 ( Subtotal = $200,000 )
2024	2024	CHILDRENS HOSPITAL MEDICAL CENTER	3333 BURNET AVE	CINCINNATI	OH	45229	HAMILTON	USA	ACL National Institute on Disability, Independent Living, and Rehabilitation Research	00	2	6/5/2024	NON-COMPETING CONTINUATION	$200,000
2024	2023	CHILDRENS HOSPITAL MEDICAL CENTER	3333 BURNET AVE	CINCINNATI	OH	45229	HAMILTON	USA	ACL National Institute on Disability, Independent Living, and Rehabilitation Research	01	1	10/11/2023	OTHER REVISION	$0
2024	2023	CHILDRENS HOSPITAL MEDICAL CENTER	3333 BURNET AVE	CINCINNATI	OH	45229	HAMILTON	USA	ACL National Institute on Disability, Independent Living, and Rehabilitation Research	00	2	6/5/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $200,000

Issue Date FY: 2023 ( Subtotal = $200,000 )
2023	2023	CHILDRENS HOSPITAL MEDICAL CENTER	3333 BURNET AVE	CINCINNATI	OH	45229	HAMILTON	USA	ACL National Institute on Disability, Independent Living, and Rehabilitation Research	00	1	8/23/2023	NEW	$200,000
														Subtotal = $200,000

Grand Total All Awards = $600,000

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A Randomized Trial of I-InTERACT Preterm: A Novel Approach to Reducing Disability in Children Born Very Preterm

Award Number: 90IFRE0075

ORGANIZATION: NATIONAL INSTITUTE ON DISABILITY, INDEPENDENT LIVING, AND REHABILITATION RESEARCH

OPDIV: ACL

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: OTHER

PERIOD OF PERFORMANCE START DATE: 09/01/2023

PERIOD OF PERFORMANCE END DATE: 08/31/2026

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