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Long Term Multidisciplinary Study of Cancer in Women: The Nurses Health Study

Award Number: UM1CA186107
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/22/2014
PERIOD OF PERFORMANCE END DATE: 06/30/2025

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Long Term Multidisciplinary Study of Cancer in Women: The Nurses Health Study - ABSTRACT This is a competing renewal of a UM1 application to support the infrastructure of the original Nurses’ Health Study (NHS), begun in 1976. The accumulated resources of NHS provide exceptional opportunities for identifying new paradigms in cancer prevention, etiology and survival. The resources encompass: lifestyle, diet and health data from 20 biennial questionnaires spanning 4 decades from 121,700 women; linked residential data on environment and neighborhood; blood samples from 32,826 participants in mid-life; a 2nd blood and morning urine in 18,743 of these women 10 years later; buccal cells from 33,040 women without blood; 62,641 toenail samples; 6,027 pre-diagnostic mammograms; tissue blocks from >14,000 patients across 16 cancers. The scientific contributions of NHS have been equally exceptional. During this funding period, accomplishments include: >400 cancer-related publications; nearly 300 resource-sharing projects by external investigators and pooling projects/consortia (a 130% increase since 2014); and participation in 33 cancer consortia, including 22 NCI consortia. Most importantly, NHS research has meaningfully guided national and international cancer guidelines on issues ranging from diet to adjuvant treatment. Our overarching goals here are to (1) efficiently expand resources with collection of key new data elements and specimens, and (2) maximize the application and sharing of existing resources, facilitating their transformation into novel cancer discoveries. First, NHS women are now >70 years of age. Over 1/3 of cancers in the US occur after age 75, and half of cancer survivors are 70+ years. Many cancer phenotype distributions appear to change with age (e.g., serous ovarian cancer becomes more common). Moreover, in the next 15 years, the proportion of the US population >70 years will grow by 60%. Thus, continued data and tumor tissue collection in NHS is critical to inform new behavioral and biological research on cancer etiology, survival and quality of life in aging. Specifically, in the next funding period, we will continue to: collect questionnaire data on behavior, quality of life, and health in aging; document cancers/ deaths; link with cancer and death registries, and Medicare claims to enhance follow-up; maintain our bio- repository; collect new tissue blocks. Second, we have had great accomplishments in data use/sharing, but this could be further increased to harness the brain-power of more cancer scientists. Mastering the large, complex data systems with decades of accumulated data elements is a challenge that inhibits efficiency of data sharing. In the next funding period, we propose to update and modernize our data systems, to grow support a large community of users via user-friendly tools for data management, visualization, and analysis. This will be done in an exciting collaboration with The Broad Institute, which is leading and developing similar platforms for The Cancer Genome Atlas, the Genotype-Tissue Expression (GTEx) project, and others.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = -$11 )
2026	2023	BRIGHAM & WOMENS HOSPITAL INC	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Cancer Cause and Prevention Research	000	10	12/4/2025	NON-COMPETING CONTINUATION	-$11
														Subtotal = -$11

Issue Date FY: 2023 ( Subtotal = $1,500,747 )
2023	2023	BRIGHAM & WOMENS HOSPITAL INC	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Cancer Cause and Prevention Research	001	10	6/22/2023	NON-COMPETING CONTINUATION	$1,500,747
2023	2022	BRIGHAM & WOMENS HOSPITAL INC	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Cancer Cause and Prevention Research	000	9	10/14/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,500,747

Issue Date FY: 2022 ( Subtotal = $1,502,634 )
2022	2022	BRIGHAM & WOMENS HOSPITAL INC	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Cancer Cause and Prevention Research	002	9	8/22/2022	NON-COMPETING CONTINUATION	$1,502,634
2022	2019	BRIGHAM & WOMENS HOSPITAL INC	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Cancer Cause and Prevention Research	001	6	10/13/2021	COMPETING CONTINUATION	$155
2022	2018	BRIGHAM & WOMENS HOSPITAL INC	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Cancer Cause and Prevention Research	000	5	10/13/2021	NON-COMPETING CONTINUATION	-$155
														Subtotal = $1,502,634

Issue Date FY: 2021 ( Subtotal = $1,505,337 )
2021	2021	BRIGHAM AND WOMEN'S HOSPITAL, INC., THE	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Cancer Cause and Prevention Research	000	8	7/7/2021	NON-COMPETING CONTINUATION	$1,505,337
														Subtotal = $1,505,337

Issue Date FY: 2020 ( Subtotal = $1,505,419 )
2020	2020	BRIGHAM AND WOMEN'S HOSPITAL, INC., THE	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Cancer Cause and Prevention Research	003	7	7/22/2020	NON-COMPETING CONTINUATION	$1,505,419
2020	2019	BRIGHAM AND WOMEN'S HOSPITAL, INC., THE	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Cancer Cause and Prevention Research	002	6	4/3/2020	COMPETING CONTINUATION	$1
2020	2019	BRIGHAM AND WOMEN'S HOSPITAL, INC., THE	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Cancer Cause and Prevention Research	000	6	12/6/2019	COMPETING CONTINUATION	$0
2020	2018	BRIGHAM AND WOMEN'S HOSPITAL, INC., THE	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Cancer Cause and Prevention Research	001	5	4/3/2020	NON-COMPETING CONTINUATION	-$1
														Subtotal = $1,505,419

Issue Date FY: 2019 ( Subtotal = $1,542,363 )
2019	2019	BRIGHAM AND WOMEN'S HOSPITAL, INC., THE	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Cancer Cause and Prevention Research	001	6	3/31/2019	COMPETING CONTINUATION	$1,542,363
2019	2018	BRIGHAM AND WOMEN'S HOSPITAL, INC., THE	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Cancer Cause and Prevention Research	000	5	12/14/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,542,363

Issue Date FY: 2018 ( Subtotal = $2,867,004 )
2018	2018	BRIGHAM AND WOMEN'S HOSPITAL, INC., THE	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Cancer Cause and Prevention Research	002	5	6/15/2018	NON-COMPETING CONTINUATION	$2,867,003
2018	2017	BRIGHAM AND WOMEN'S HOSPITAL, INC., THE	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Cancer Cause and Prevention Research	000	3	3/30/2018	SUPPLEMENT FOR EXPANSION	$0
2018	2017	BRIGHAM AND WOMEN'S HOSPITAL, INC., THE	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Cancer Cause and Prevention Research	001	4	6/7/2018	NON-COMPETING CONTINUATION	$1
														Subtotal = $2,867,004

Issue Date FY: 2017 ( Subtotal = $2,989,275 )
2017	2017	BRIGHAM AND WOMEN'S HOSPITAL, INC., THE	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Cancer Cause and Prevention Research	001	3	9/15/2017	SUPPLEMENT FOR EXPANSION	$124,703
2017	2017	BRIGHAM AND WOMEN'S HOSPITAL, INC., THE	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Cancer Cause and Prevention Research	000	4	6/30/2017	NON-COMPETING CONTINUATION	$2,864,572
														Subtotal = $2,989,275

Issue Date FY: 2016 ( Subtotal = $2,936,536 )
2016	2016	BRIGHAM & WOMEN`S HOSPITAL	10 VINING STREET	BOSTON	MA	02115	SUFFOLK	USA	Cancer Cause and Prevention Research	000	3	8/17/2016	NON-COMPETING CONTINUATION	$2,936,536
														Subtotal = $2,936,536

Issue Date FY: 2015 ( Subtotal = $2,948,014 )
2015	2015	BRIGHAM & WOMEN`S HOSPITAL	10 VINING STREET	BOSTON	MA	02115	SUFFOLK	USA	Cancer Cause and Prevention Research	000	2	6/26/2015	NON-COMPETING CONTINUATION	$2,948,014
														Subtotal = $2,948,014

Issue Date FY: 2014 ( Subtotal = $2,972,053 )
2014	2014	BRIGHAM & WOMEN`S HOSPITAL	10 VINING STREET	BOSTON	MA	02115	SUFFOLK	USA	Cancer Cause and Prevention Research	000	1	7/22/2014	NEW	$2,972,053
														Subtotal = $2,972,053

Grand Total All Awards = $22,269,371

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Long Term Multidisciplinary Study of Cancer in Women: The Nurses Health Study

Award Number: UM1CA186107

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/22/2014

PERIOD OF PERFORMANCE END DATE: 06/30/2025

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