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Innovative Translational Imaging Technologies to Monitor Genome Edited Cells in Vivo

Award Number: UH2EB028910
ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Group Awards By Issue Date FY or Funding FY:

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PROJECT SUMMARY / ABSTRACT This application is submitted in response to RFA-RM-18-025, which is focused on the development of new technologies to noninvasively label and monitor genome-edited cells in vivo. Our submission meets the objective of the RFA by establishing a new field of total-body positron emission tomography (PET) imaging for somatic cell genome editing, and with quantitative methodologies needed to support translation. This application is grounded in a proven infrastructure of innovative tools, technologies, and resources, and a highly accomplished multidisciplinary team of investigators. Studies will culminate in translational tools for the in vitro design (phantoms, quantitative measures) and in vivo methods for monitoring genome-edited cells that will inform future clinical investigations across organ systems for the treatment of human disease. The UH2 phase will focus on in vitro and in vivo quantitative testing with edited cells in prototype models (Specific Aim 1). The activities in these studies can be adapted to any cell type or organ system. The UH3 phase will address detection efficiency and safety assessments in vivo, including the potential for immune responses in an animal model that employs quantitative imaging analysis and related tools for translation (Specific Aim 2). Overall, these investigations will establish a new field of total-body PET imaging for monitoring the safety and efficiency of somatic cell genome editing and will contribute new knowledge that leads to future well-designed preclinical studies and human clinical trials.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2022 ( Subtotal = -$46,803 )
2022	2020	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Trans-NIH Research Support	000	2	8/31/2022	NON-COMPETING CONTINUATION	-$46,803
														Subtotal = -$46,803

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2020	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Trans-NIH Research Support	000	2	4/12/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $227,939 )
2020	2020	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Trans-NIH Research Support	001	2	8/28/2020	NON-COMPETING CONTINUATION	$227,939
2020	2019	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Trans-NIH Research Support	000	1	8/28/2020	NEW	$0
														Subtotal = $227,939

Issue Date FY: 2019 ( Subtotal = $235,492 )
2019	2019	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Trans-NIH Research Support	000	1	9/12/2019	NEW	$235,492
2019	2019	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Trans-NIH Research Support	002	1	9/25/2019	NEW	$3,900
2019	2019	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Trans-NIH Research Support	001	1	9/24/2019	NEW	-$3,900
														Subtotal = $235,492

Grand Total All Awards = $416,628

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Innovative Translational Imaging Technologies to Monitor Genome Edited Cells in Vivo

Award Number: UH2EB028910

ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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