Saturday, November 23, 2024 11/23/2024

Engineered AAV Identification, Validation, and Dissemination Pipeline for Brain Cell Type-Specific Manipulation Across Species

Award Number: UF1MH128336
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Group Awards By:

View Award Abstract

PROJECT SUMMARY: This team initiative will provide the broad neuroscience community with a cell type-specific adeno- associated virus (AAV) armamentarium for easy and non-invasive implementation of novel and emerging molecular tools for anatomical and functional analysis of the nervous system in rodents, non-human primates, and human organoids. We will characterize engineered AAV capsids for cell type- and brain region-specific gene delivery (Aim 1). We will pair these capsids with cargos of recently optimized and newly developed sensors and effectors, largely enabled by the BRAIN Initiative, and validate their functional utility for large- scale monitoring and manipulation of brain function across species (Aim 2). Finally, we will establish an electronic AAV resource portal to catalogue and disseminate all of these tools to the broader research community (Aim 3). This proposal promises to validate a broad array of engineered systemic AAVs with access to molecularly defined neuronal cell types for delivery of BRAIN-relevant cargo and functional interrogation of brain cells across species. To maximize the utility of these tools to the neuroscientific community, we will engage in broad collaboration and dissemination. Building on the CLOVER Center’s established network of AAV production facilities, we will facilitate the broad adoption of systemic AAVs through consultation and collaboration, including provision of cost- free sample AAV preps. We will explore methodological innovations in AAV production and administration while catalyzing the early-stage adoption and validation of engineered capsids identified in this proposal by creating an electronic AAV resource for dissemination of reagents and best practices, containing catalogued AAV brain atlases and a data re-capture portal for continuous, crowd-sourced validation. The expertise and infrastructure built over the life of this proposal will form the foundation of a long-term comprehensive center for AAV BRAIN SENSUS (Safe and Effective Neuromodulator and Sensor Utilization across Species) that will open new doors for neuroscience tool validation and dissemination.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2021	CALIFORNIA INSTITUTE OF TECHNOLOGY	1200 E CALIFORNIA BLVD	PASADENA	CA	91125	LOS ANGELES	USA	Mental Health Research Grants	000	1	10/18/2024	NEW	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2021	CALIFORNIA INSTITUTE OF TECHNOLOGY	1200 E CALIFORNIA BLVD	PASADENA	CA	91125	LOS ANGELES	USA	Mental Health Research Grants	000	1	2/2/2023	NEW	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $6,133,641 )
2021	2021	CALIFORNIA INSTITUTE OF TECHNOLOGY	1200 E CALIFORNIA BLVD	PASADENA	CA	91125	LOS ANGELES	USA	Mental Health Research Grants	000	1	9/20/2021	NEW	$6,133,641
														Subtotal = $6,133,641

Grand Total All Awards = $6,133,641

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Engineered AAV Identification, Validation, and Dissemination Pipeline for Brain Cell Type-Specific Manipulation Across Species

Award Number: UF1MH128336

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer