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AnVIL Clinical Environment for Innovation and Translation (ACE-IT)

Award Number: U24HG013233
ORGANIZATION: NATIONAL HUMAN GENOME RESEARCH INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/21/2023
PERIOD OF PERFORMANCE END DATE: 01/31/2029

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AnVIL Clinical Environment for Innovation and Translation (ACE-IT) - The Analysis, Visualization, and Informatics Lab-space (AnVIL) platform is a scalable cloud-based computing resource that aims to accelerate genomics research by providing broad access to genomics datasets and the infrastructure necessary to improve analysis workflows and enhance collaboration. The AnVIL Clinical Environment for Innovation and Translation (ACE-IT) project will bring together a network of expertise to address a major gap in clinical genomics research and operationalize a key mission of the AnVIL project by expanding its existing ecosystem to include a comprehensive suite of clinical genomics research tools and services. The newly developed AnVIL Clinical Resource will bring together data, tools, and support resources meant to amplify the benefits of the existing platform and provide a critical foundation for the clinical genomics research community to better leverage this innovative resource. Development of the ACE-IT will be guided by three key aims: 1. Engagement with clinical community and research partners to characterize barriers and facilitators to adopting federally-supported, cloud-connected clinical genomics research services; 2. Develop and deploy approaches to ingest, index, and search data to support clinical genomics research; and 3. Integration of tools, APIs, and workflows that enable clinical genomics research methods on the AnVIL, including rare disease diagnosis and genomic risk scores as use cases. The ACE-IT team consists of expertise across multiple health care centers, including Vanderbilt University Medical Center, Brigham and Women’s Hospital, and Massachusetts General Hospital. This team will develop infrastructure on AnVIL’s cloud environment to meet clinical genomics researchers' needs over time and integrate with existing AnVIL working groups and meetings as team members and stakeholders where appropriate. The tools and resources we develop will support clinical genomics research by focusing on both rare and common diseases and integration into translational research.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $1,429,420 )
2026	2026	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Human Genome Research	000	3	1/29/2026	NON-COMPETING CONTINUATION	$1,429,420
														Subtotal = $1,429,420

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Human Genome Research	000	2	9/11/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $1,589,296 )
2024	2024	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Human Genome Research	001	2	5/31/2024	NON-COMPETING CONTINUATION	$1,424,502
2024	2024	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Human Genome Research	000	1	2/12/2024	SUPPLEMENT FOR EXPANSION	$164,794
														Subtotal = $1,589,296

Issue Date FY: 2023 ( Subtotal = $1,494,387 )
2023	2023	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Human Genome Research	000	1	8/21/2023	NEW	$1,494,387
														Subtotal = $1,494,387

Grand Total All Awards = $4,513,103

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AnVIL Clinical Environment for Innovation and Translation (ACE-IT)

Award Number: U24HG013233

ORGANIZATION: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/21/2023

PERIOD OF PERFORMANCE END DATE: 01/31/2029

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