Thursday, April 18, 2024 4/18/2024

Collaborating Consortium of Cohorts Producing NIDA Opportunities (C3PNO) Second Bridge Funding Supplement

Award Number: U24DA044554
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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ABSTRACT In response to RFA-DA-17-019 we propose to establish a Coordinating Center for the NIDA Cohorts entitled “C3NPO” * to manage and stimulate use of the data generated to address high priority research on HIV/AIDS in the context of substance abuse. Our focus is cutting-edge science powered by the cohorts' combined sample size of approximately 12,500 participants. We bring together a team of researchers with global leadership in substance use, HIV prevention, clinical science and co-morbidities, immunology, modeling, and bioethics to work with NIDA program scientists to stimulate the highest impact science across NIDA-funded cohorts that have compiled unique repositories of varied and rich data. Our proposal uniquely combines academic and professional research management expertise that will stimulate, manage, and support scientific collaboration. We will enable internal and external investigators to cultivate the data from these cohorts in new and innovative scientific directions. Our bioinformatics capacity is uniquely strong in the area of specimen management, having developed the industry gold standard software that will greatly facilitate sharing of specimens across the cohorts. Our leadership bridges NIDA's interests with the perspectives and concerns of the cohorts by having a cohort PI/research scientist (Pamina Gorbach, University of California, Los Angeles) partnered with an experienced HIV network bioinformatics management leader (Suzanne Siminski, Frontier Science & Technology Research Foundation (FSTRF). We will leverage other funded research initiatives though our External Scientific Advisory Board (ESAB) such as NIDA-supported efforts to harmonize measures for substance use research and combine that with data linking strategies. We have the endorsement of all cohort PIs that Consortium leadership is best led from another cohort PI to enhance team science and support for our team as the leaders. The collaborative character of this proposing team offers the potential for new developments in bioinformatics techniques that allow integration of diverse and ever more massive sets of behavioral, clinical, and laboratory data for use by cohort and outside researchers. Thus, our proposal will address NIDA's 2016-2020 Strategic Plan priority focus areas and cross-cutting themes (https://www.drugabuse.gov/about-nida/2016-2020-nida-strategic-plan) by leveraging technology, driving innovation, promoting collaboration, and encouraging data and resource sharing. The strategy will develop infrastructure that allows cross-disciplinary, large-scale analyses leading to the highest impact HIV science on substance use.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$62,705 )
2024	2022	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Drug Abuse and Addiction Research Programs	000	5	12/19/2023	SUPPLEMENT FOR EXPANSION	-$62,705
														Subtotal = -$62,705

Issue Date FY: 2022 ( Subtotal = $1,000,961 )
2022	2022	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Drug Abuse and Addiction Research Programs	002	5	5/20/2022	SUPPLEMENT FOR EXPANSION	$490,310
2022	2022	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Drug Abuse and Addiction Research Programs	001	5	3/23/2022	SUPPLEMENT FOR EXPANSION	$510,651
2022	2021	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Drug Abuse and Addiction Research Programs	000	5	3/11/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,000,961

Issue Date FY: 2021 ( Subtotal = $1,373,349 )
2021	2021	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Drug Abuse and Addiction Research Programs	003	5	5/27/2021	SUPPLEMENT FOR EXPANSION	$400,898
2021	2021	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Drug Abuse and Addiction Research Programs	002	5	2/19/2021	NON-COMPETING CONTINUATION	$972,451
2021	2020	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Drug Abuse and Addiction Research Programs	001	4	1/29/2021	NON-COMPETING CONTINUATION	$0
2021	2020	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Drug Abuse and Addiction Research Programs	000	4	12/16/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,373,349

Issue Date FY: 2020 ( Subtotal = $1,280,201 )
2020	2020	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Drug Abuse and Addiction Research Programs	003	4	7/10/2020	SUPPLEMENT FOR EXPANSION	$326,106
2020	2020	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Drug Abuse and Addiction Research Programs	002	4	2/10/2020	NON-COMPETING CONTINUATION	$954,095
2020	2019	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Drug Abuse and Addiction Research Programs	000	3	11/6/2019	NON-COMPETING CONTINUATION	$124,291
2020	2019	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Drug Abuse and Addiction Research Programs	001	3	11/20/2019	NON-COMPETING CONTINUATION	-$124,291
														Subtotal = $1,280,201

Issue Date FY: 2019 ( Subtotal = $1,117,464 )
2019	2019	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Drug Abuse and Addiction Research Programs	002	3	6/20/2019	SUPPLEMENT FOR EXPANSION	$155,569
2019	2019	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Drug Abuse and Addiction Research Programs	001	3	2/19/2019	NON-COMPETING CONTINUATION	$961,895
2019	2018	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Drug Abuse and Addiction Research Programs	000	2	11/30/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,117,464

Issue Date FY: 2018 ( Subtotal = $980,079 )
2018	2018	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Drug Abuse and Addiction Research Programs	001	2	4/26/2018	NON-COMPETING CONTINUATION	$98,008
2018	2018	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Drug Abuse and Addiction Research Programs	000	2	3/6/2018	NON-COMPETING CONTINUATION	$882,071
														Subtotal = $980,079

Issue Date FY: 2017 ( Subtotal = $999,893 )
2017	2017	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Drug Abuse and Addiction Research Programs	000	1	4/28/2017	NEW	$999,893
														Subtotal = $999,893

Grand Total All Awards = $6,689,242

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Collaborating Consortium of Cohorts Producing NIDA Opportunities (C3PNO) Second Bridge Funding Supplement

Award Number: U24DA044554

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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