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Enhance the surveillance of foodborne bacterial pathogens isolated from food and environmental samples using whole genome sequencing (WGS) to prevent foodborne outbreaks and promote public health

Award Number: U19FD007113
ORGANIZATION: FOOD AND DRUG ADMINISTRATION
OPDIV: FDA
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Summary: Overall Since 2016, North Carolina State University (NCSU) has helped expand the GenomeTrakr program on a national and global scale to target some of the leading causes of foodborne illnesses worldwide. The need for surveillance of foodborne pathogens is urgent because despite advances in hygiene, food and water quality and pathogen detection, foodborne illnesses remain a tremendous burden for public health. The environment and food products such as retail meats are implicated as sources of foodborne pathogens, and establishing standardized surveillance of these sources can help monitor key pathogens and trace contamination routes to prevent and control outbreaks. To date, NCSU GenomeTrakr laboratories have generated 3,328 whole genome sequencing (WGS) profiles of bacterial pathogens isolated from multiple sources. This includes profiles of 1,127 bacterial isolates from 9 countries outside the US over the last three years. They have also trained 23 students and professionals from 10 countries, which has led to 11 original publications of GenomeTrakr program data in peer-reviewed journals coauthored by the investigators and their US and international trainees. Since 2016, the investigators have worked to expand their global network to now include 13 countries spanning three continents. Consequently, the overarching aim of this project is to continue enhancing WGS- based surveillance of bacterial pathogens associated with foodborne illness at the national and global level using a One Health approach. This will be achieved through surveillance activities, partnership building and training students and professionals. The investigators will leverage their extensive leadership experience in surveillance protocols, advanced molecular techniques and data analysis, and their status as a WHO Collaborating Center for AMR and One Health to build capacity in the US and globally through world-class training for students and professionals. To achieve this, they will pursue the following specific aims. Aim 1 (Project): Expand the existing surveillance system of bacterial pathogens related to foodborne illness that have been isolated from food and environmental sources in the US and international locations. Aim 2 (Project): Compare WGS profiles of bacterial pathogens isolated from national and international samples to advance outbreak investigations and track emerging strains of public health importance. This work will be supported by two aims of the Administrative Core: Aim 1 (Admin): Provide leadership to complete the proposed aims in collaboration with national and international institutions. Aim 2 (Admin): Provide a framework to educate and equip the future surveillance workforce with the knowledge and skills needed for WGS analysis. Expected Outcomes: The investigators are committed to fulfilling the GenomeTrakr mission and expanding standardized surveillance systems across the globe. By characterizing 400 new isolates from US and international sources from new and existing collaborators, and by building capacity worldwide, this work will help public health agencies track the emergence of new strains, curb the distribution of foodborne pathogens and reduce the burden of foodborne illnesses in the US and globally.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $173,894 )
2023	2023	NORTH CAROLINA STATE UNIVERSITY	2601 WOLF VILLAGE WAY	RALEIGH	NC	27607	WAKE	USA	Food and Drug Administration Research	001	4	6/29/2023	NON-COMPETING CONTINUATION	$180,000
2023	2023	NORTH CAROLINA STATE UNIVERSITY	2601 WOLF VILLAGE WAY	RALEIGH	NC	27607	WAKE	USA	Food and Drug Administration Research	002	4	7/18/2023	NON-COMPETING CONTINUATION	-$6,106
2023	2021	NORTH CAROLINA STATE UNIVERSITY	2601 WOLF VILLAGE WAY	RALEIGH	NC	27607	WAKE	USA	Food and Drug Administration Research	000	2	11/4/2022	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $173,894

Issue Date FY: 2022 ( Subtotal = $179,994 )
2022	2022	NORTH CAROLINA STATE UNIVERSITY	2601 WOLF VILLAGE WAY	RALEIGH	NC	27607	WAKE	USA	Food and Drug Administration Research	001	3	8/12/2022	NON-COMPETING CONTINUATION	$0
2022	2022	NORTH CAROLINA STATE UNIVERSITY	2601 WOLF VILLAGE WAY	RALEIGH	NC	27607	WAKE	USA	Food and Drug Administration Research	000	3	7/21/2022	NON-COMPETING CONTINUATION	$179,994
														Subtotal = $179,994

Issue Date FY: 2021 ( Subtotal = $357,814 )
2021	2021	NORTH CAROLINA STATE UNIVERSITY	2601 WOLF VILLAGE WAY	RALEIGH	NC	27607	WAKE	USA	Food and Drug Administration Research	003	2	8/2/2021	NON-COMPETING CONTINUATION	-$180,151
2021	2021	NORTH CAROLINA STATE UNIVERSITY	2601 WOLF VILLAGE WAY	RALEIGH	NC	27607	WAKE	USA	Food and Drug Administration Research	004	2	8/5/2021	SUPPLEMENT FOR EXPANSION	$180,151
2021	2021	NORTH CAROLINA STATE UNIVERSITY	2601 WOLF VILLAGE WAY	RALEIGH	NC	27607	WAKE	USA	Food and Drug Administration Research	002	2	7/7/2021	NON-COMPETING CONTINUATION	$357,814
2021	2020	NORTH CAROLINA STATE UNIVERSITY	2601 WOLF VILLAGE WAY	RALEIGH	NC	27607	WAKE	USA	Food and Drug Administration Research	000	1	10/14/2020	NEW	$0
2021	2020	NORTH CAROLINA STATE UNIVERSITY	2601 WOLF VILLAGE WAY	RALEIGH	NC	27607	WAKE	USA	Food and Drug Administration Research	001	1	12/15/2020	NEW	$0
														Subtotal = $357,814

Issue Date FY: 2020 ( Subtotal = $179,944 )
2020	2020	NORTH CAROLINA STATE UNIVERSITY	2601 WOLF VILLAGE WAY	RALEIGH	NC	27607	WAKE	USA	Food and Drug Administration Research	000	1	9/8/2020	NEW	$179,944
														Subtotal = $179,944

Grand Total All Awards = $891,646

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Enhance the surveillance of foodborne bacterial pathogens isolated from food and environmental samples using whole genome sequencing (WGS) to prevent foodborne outbreaks and promote public health

Award Number: U19FD007113

ORGANIZATION: FOOD AND DRUG ADMINISTRATION

OPDIV: FDA

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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