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System Biological Analyses of Innate and Adaptive Responses to Vaccination

Award Number: U19AI090023
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Group Awards By Issue Date FY or Funding FY:

View Award Abstract

The research proposed in years 6 and 7 of the Emory-HIPC will build on the considerable progress made during the first 5 years in using systems based approaches to understand the molecular networks driving innate and adaptive immune responses to vaccination. The major focus of the work planned in years 6 and 7 is to understand the immunological mechanisms by which the recently licensed subunit vaccine for herpes zoster (HZ, shingles) induces highly efficacious protection against shingles. HZ which is caused by the varicella zoster virus (VZV), affects several million people/year globally, and is a significant public health concern for the elderly. An important recent development is the development of a new subunit HZ vaccine, which contains the recombinant glycoprotein E subunit (“gE vaccine”), adjuvanted with AS01, a liposome-based adjuvant system containing the TLR4 agonist MPL, and the saponin, QS21 (1-4). The gE vaccine has recently been licensed for clinical use in subjects older than 50 years, under the trade name Shingrix®. Remarkably, the efficacy of Shingrix® is high (91%) even in 70 year old vaccinees (1-4). Although Shingrix® has revealed superior antibody responses and greater durability of CD4+ T cell responses to the gE vaccine, a comprehensive assessment of immune responses to the gE vaccine is lacking. This will be achieved in Aims 1 and 2, where we will analyze the innate and adaptive responses to Shingrix®. Importantly we will analyze these results in the context of data generated from our previous HIPC project on immune responses induced by the live attenuated zoster vaccine, Zostavax®. Aim 1: Systems analysis of innate responses elicited by Shingrix® in 50-60 year old and >70 year old subjects. Aim 2: To analyze the adaptive immune response elicited by Shingrix® in 50-59 year old and >70-85 years old subjects.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$289,024 )
2024	2021	EMORY UNIVERSITY	201 DOWMAN DR NE	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	002	12	3/26/2024	NON-COMPETING CONTINUATION	-$251,207
2024	2021	EMORY UNIVERSITY	201 DOWMAN DR NE	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	001	12	2/1/2024	SUPPLEMENT FOR EXPANSION	-$2,018
2024	2020	EMORY UNIVERSITY	201 DOWMAN DR NE	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	000	11	2/1/2024	SUPPLEMENT FOR EXPANSION	-$35,799
														Subtotal = -$289,024

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2021	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	000	12	10/28/2022	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $369 )
2022	2020	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	000	11	8/5/2022	SUPPLEMENT FOR EXPANSION	$0
2022	2019	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	001	10	9/26/2022	NON-COMPETING CONTINUATION	$369
														Subtotal = $369

Issue Date FY: 2021 ( Subtotal = $3,147,703 )
2021	2021	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	004	12	8/18/2021	NON-COMPETING CONTINUATION	$2,213,568
2021	2021	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	006	12	8/31/2021	SUPPLEMENT FOR EXPANSION	$467,690
2021	2021	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	000	11	3/1/2021	SUPPLEMENT FOR EXPANSION	$466,445
2021	2020	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	005	11	8/23/2021	SUPPLEMENT FOR EXPANSION	$0
2021	2020	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	003	11	7/1/2021	EXTENSION WITH OR WITHOUT FUNDS	$2,201,193
2021	2020	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	001	11	3/30/2021	EXTENSION WITH OR WITHOUT FUNDS	$0
2021	2019	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	002	10	7/1/2021	NON-COMPETING CONTINUATION	-$2,201,193
														Subtotal = $3,147,703

Issue Date FY: 2020 ( Subtotal = $9,830,191 )
2020	2020	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	000	11	6/24/2020	EXTENSION WITH OR WITHOUT FUNDS	$2,404,885
2020	2020	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	001	11	7/13/2020	SUPPLEMENT FOR EXPANSION	$7,425,306
														Subtotal = $9,830,191

Issue Date FY: 2019 ( Subtotal = $3,004,688 )
2019	2019	EMORY UNIVERSITY	1599 CLIFTON RD.	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	001	10	7/10/2019	NON-COMPETING CONTINUATION	$3,004,688
2019	2018	EMORY UNIVERSITY	1599 CLIFTON RD.	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	000	9	4/5/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $3,004,688

Issue Date FY: 2018 ( Subtotal = $3,369,727 )
2018	2018	EMORY UNIVERSITY	1599 CLIFTON RD.	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	000	9	6/20/2018	NON-COMPETING CONTINUATION	$2,987,174
2018	2018	EMORY UNIVERSITY	1599 CLIFTON RD.	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	001	9	8/21/2018	NON-COMPETING CONTINUATION	$382,553
														Subtotal = $3,369,727

Issue Date FY: 2017 ( Subtotal = $2,963,327 )
2017	2017	EMORY UNIVERSITY	1599 CLIFTON RD.	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	000	8	6/28/2017	NON-COMPETING CONTINUATION	$2,963,327
														Subtotal = $2,963,327

Issue Date FY: 2016 ( Subtotal = $3,178,141 )
2016	2016	EMORY UNIVERSITY	1784 N DECATUR RD,S 530 NDBLDG	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	000	7	6/9/2016	NON-COMPETING CONTINUATION	$3,178,141
														Subtotal = $3,178,141

Issue Date FY: 2015 ( Subtotal = $3,109,475 )
2015	2015	EMORY UNIVERSITY	1784 N DECATUR RD,S 530 NDBLDG	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	000	6	7/1/2015	COMPETING CONTINUATION	$3,109,475
														Subtotal = $3,109,475

Issue Date FY: 2014 ( Subtotal = $2,787,192 )
2014	2014	EMORY UNIVERSITY	1784 N DECATUR RD,S 530 NDBLDG	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	000	5	6/24/2014	NON-COMPETING CONTINUATION	$2,787,192
														Subtotal = $2,787,192

Issue Date FY: 2013 ( Subtotal = $2,937,945 )
2013	2013	EMORY UNIVERSITY	1784 N DECATUR RD,S 530 NDBLDG	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	000	4	6/22/2013	NON-COMPETING CONTINUATION	$2,937,945
														Subtotal = $2,937,945

Issue Date FY: 2012 ( Subtotal = $3,068,402 )
2012	2012	EMORY UNIVERSITY	1784 N DECATUR RD,S 530 NDBLDG	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	000	3	6/21/2012	NON-COMPETING CONTINUATION	$3,068,402
														Subtotal = $3,068,402

Issue Date FY: 2011 ( Subtotal = $4,398,252 )
2011	2011	EMORY UNIVERSITY	1784 N DECATUR RD,S 530 NDBLDG	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	002	2	9/8/2011	EXTENSION WITH OR WITHOUT FUNDS	$0
2011	2011	EMORY UNIVERSITY	1784 N DECATUR RD,S 530 NDBLDG	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	005	2	9/16/2011	EXTENSION WITH OR WITHOUT FUNDS	$500,000
2011	2011	EMORY UNIVERSITY	1784 N DECATUR RD,S 530 NDBLDG	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	004	2	9/15/2011	EXTENSION WITH OR WITHOUT FUNDS	$720,509
2011	2011	EMORY UNIVERSITY	1784 N DECATUR RD,S 530 NDBLDG	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	000	2	8/5/2011	EXTENSION WITH OR WITHOUT FUNDS	$3,067,743
2011	2011	EMORY UNIVERSITY	1784 N DECATUR RD,S 530 NDBLDG	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	001	2	9/7/2011	EXTENSION WITH OR WITHOUT FUNDS	$80,000
2011	2011	EMORY UNIVERSITY	1784 N DECATUR RD,S 530 NDBLDG	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	003	2	9/14/2011	EXTENSION WITH OR WITHOUT FUNDS	$30,000
														Subtotal = $4,398,252

Issue Date FY: 2010 ( Subtotal = $3,213,142 )
2010	2010	EMORY UNIVERSITY	1784 N DECATUR RD,S 530 NDBLDG	ATLANTA	GA	30322	DEKALB	USA	Trans-NIH Recovery Act Research Support	000	1	7/12/2010	NEW	$3,213,142
														Subtotal = $3,213,142

Grand Total All Awards = $44,719,530

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System Biological Analyses of Innate and Adaptive Responses to Vaccination

Award Number: U19AI090023

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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