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Translating Research Into Practice: A Regional Collaborative to Reduce Disparities in Breast Cancer Care

Award Number: U01TR002070
ORGANIZATION: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary The transfer and application of scientific evidence into everyday practice is necessary to mitigate health disparities, yet roadblocks persist in broad implementation of evidence-based interventions among vulnerable communities experiencing disparities. The Boston Breast Cancer Equity Coalition was formed in 2014 in response to persistent city-wide disparities in breast cancer mortality among minority, low-income women. The Coalition identified three evidence-based strategies known to reduce delays in care that have yet to be deployed into clinical practice, due to a lack of implementation strategies (T3-T4 implementation translation). Translating Research into Practice (TRIP) draws upon the principles of community-engaged dissemination and implementation science to systematically facilitate deployment and utilization of: (a) regional patient registries; (b) systematic screening for social barriers to care with a personalized referral plan; and (c) patient navigation services into one integrated model of care to improve the quality and effectiveness of care delivery, in this case for minority and/or low-income women with breast cancer. The four Massachusetts CTSA hubs (Boston University, Harvard University, Tufts University, and University of Massachusetts) partnered with the Boston Breast Cancer Equity Coalition to overcome barriers to widespread implementation and dissemination of evidence based practices that will improve the delivery of guideline-concordant care to vulnerable women. The study will be conducted in three phases: First, we will deploy regional CTSA expertise to support the local healthcare community to develop the three individual TRIP components, create the study data repository, and refine and integrate the intervention components into a cohesive package that can be implemented within the context of the clinical work flow of the partnering sites. Then, we will conduct a type 1 hybrid effectiveness- implementation study among 1,100 vulnerable breast cancer patients seeking care across six health systems in Boston. We will evaluate the healthcare system’s ability to implement these three generalizable tools (fidelity to intervention protocol, costs, local adoption/sustainability, and acceptability) into an integrated intervention and the impact on clinical outcomes (time to first treatment and receipt of guideline concordant cancer care). Finally, we will promote widespread dissemination to other CTSA hubs, health systems, and community- academic partnerships. Our main hypothesis is that widespread implementation of these tools will eliminate care delivery disparities, and CTSA hubs have the translational expertise to overcome barriers to such implementation.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$13,565 )
2024	2021	BOSTON MEDICAL CENTER CORPORATION	1 BOSTON MEDICAL CTR PL	BOSTON	MA	02118	SUFFOLK	USA	National Center for Advancing Translational Sciences	000	5	2/13/2024	NON-COMPETING CONTINUATION	-$13,565
														Subtotal = -$13,565

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2021	BOSTON MEDICAL CENTER CORPORATION	1 BOSTON MEDICAL CTR PL STE 1	BOSTON	MA	02118	SUFFOLK	USA	National Center for Advancing Translational Sciences	000	5	6/10/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $1,691,973 )
2021	2021	BOSTON MEDICAL CENTER CORPORATION	1 BOSTON MEDICAL CENTER PL STE 1	BOSTON	MA	02118	SUFFOLK	USA	National Center for Advancing Translational Sciences	000	5	6/4/2021	NON-COMPETING CONTINUATION	$1,691,973
														Subtotal = $1,691,973

Issue Date FY: 2020 ( Subtotal = $1,696,376 )
2020	2020	BOSTON MEDICAL CENTER CORPORATION	1 BOSTON MEDICAL CENTER PL STE 1	BOSTON	MA	02118	SUFFOLK	USA	National Center for Advancing Translational Sciences	001	4	5/30/2020	NON-COMPETING CONTINUATION	$1,696,376
2020	2019	BOSTON MEDICAL CENTER CORPORATION	1 BOSTON MEDICAL CENTER PL STE 1	BOSTON	MA	02118	SUFFOLK	USA	National Center for Advancing Translational Sciences	000	3	1/21/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,696,376

Issue Date FY: 2019 ( Subtotal = $1,696,377 )
2019	2019	BOSTON MEDICAL CENTER CORPORATION	1 BOSTON MEDICAL CENTER PL STE 1	BOSTON	MA	02118	SUFFOLK	USA	National Center for Advancing Translational Sciences	001	3	7/2/2019	NON-COMPETING CONTINUATION	$1,696,377
2019	2018	BOSTON MEDICAL CENTER CORPORATION	1 BOSTON MEDICAL CENTER PL STE 1	BOSTON	MA	02118	SUFFOLK	USA	National Center for Advancing Translational Sciences	000	2	2/27/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,696,377

Issue Date FY: 2018 ( Subtotal = $1,733,162 )
2018	2018	BOSTON MEDICAL CENTER CORPORATION	1 BOSTON MEDICAL CENTER PL STE 1	BOSTON	MA	02118	SUFFOLK	USA	National Center for Advancing Translational Sciences	001	2	9/19/2018	NON-COMPETING CONTINUATION	$38,187
2018	2018	BOSTON MEDICAL CENTER CORPORATION	1 BOSTON MEDICAL CENTER PL STE 1	BOSTON	MA	02118	SUFFOLK	USA	National Center for Advancing Translational Sciences	000	2	6/7/2018	NON-COMPETING CONTINUATION	$1,694,975
														Subtotal = $1,733,162

Issue Date FY: 2017 ( Subtotal = $1,850,336 )
2017	2017	BOSTON MEDICAL CENTER CORPORATION	88 EAST NEWTON ST	BOSTON	MA	02118	SUFFOLK	USA	National Center for Advancing Translational Sciences	000	1	8/30/2017	NEW	$1,850,336
														Subtotal = $1,850,336

Grand Total All Awards = $8,654,659

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Translating Research Into Practice: A Regional Collaborative to Reduce Disparities in Breast Cancer Care

Award Number: U01TR002070

ORGANIZATION: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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