Thursday, April 25, 2024 4/25/2024

High-performance compact 3T MRI: Technical optimization for advanced brain imaging

Award Number: U01EB024450
ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Group Awards By Issue Date FY or Funding FY:

View Award Abstract

PROJECT SUMMARY/ABSTRACT A breakthrough lightweight, compact 3T MR scanner has been demonstrated to have gradient performance of 700 T/m/s slew rate, operating at 80 mT/m amplitude), which is a slew rate that is 3.5x faster than whole-body MRIs. The proposed next phase of the program will deliver key neuroimaging tools through a multi-disciplinary collaboration between Mayo Clinic and GE Global Research. This proposed work includes further technical development in image reconstruction, systems artifact correction, and pulse sequence programming that exploits the unique, high-performance capabilities of the compact 3T. The Specific Aims of the project are to: · Aim 1) Develop Core Technologies for Echo Planar Imaging (EPI) on the Compact 3T · Aim 2) Develop New MRI-based Connectomics · Aim 3) Develop High-Resolution MR Elastography (MRE) Brain Stiffness Measurement Aim 1 focuses on improving EPI on the compact 3T system to maximally capitalize on its unique gradient slew rate and specific absorption rate (SAR) advantages. Specific tasks related to this aim include: the development of model-based reconstructions, real-time system compensation to eliminate concomitant field artifacts, pulse sequence development for segmented EPI for very fast anatomical imaging, and improved efficiency for simultaneous multislice (SMS) by exploiting the SAR advantages. Aim 2 exploits the compact 3T's dramatically reduced susceptibility artifacts in the region of the medial temporal lobe to enable task-free fMRI spontaneous coactiviation studies of the entire brain, including the hippocampus, which is central to the study of Alzheimer's disease (AD). Aim 3 describes how the compact 3T's high-performance gradients enable, for the first time, 3D gradient echo-based MR elastography (3DMRE). This will enable an 8x reduction in the acquired voxel size compared with the 2DMRE currently acquired with our whole-body MRIs. This has important applications, not-only to pre-surgical planning for tumor resection, but also to potentially develop new biomarkers for the study of neurodenegerative disease, such as AD. The new 3DMRE technique will be studied in the same patient cohort as Aim 2. We believe vastly improved spatial resolution and scan efficiency on the compact 3T MR platform will enable new clinical and neuroscience applications for assessing brain disease management, including traumatic brain injury, tumor treatment planning, and neurodegenerative diseases.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$50,509 )
2024	2021	MAYO CLINIC	200 1ST ST SW	ROCHESTER	MN	55905	OLMSTED	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	5	2/22/2024	NON-COMPETING CONTINUATION	-$50,509
														Subtotal = -$50,509

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2021	MAYO CLINIC	200 FIRST ST SW	ROCHESTER	MN	55905	OLMSTED	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	5	11/8/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $990,588 )
2021	2021	MAYO CLINIC	200 FIRST ST SW	ROCHESTER	MN	55905	OLMSTED	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	5	7/26/2021	NON-COMPETING CONTINUATION	$990,588
														Subtotal = $990,588

Issue Date FY: 2020 ( Subtotal = $1,036,002 )
2020	2020	MAYO CLINIC	200 FIRST ST SW	ROCHESTER	MN	55905	OLMSTED	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	4	6/23/2020	NON-COMPETING CONTINUATION	$1,036,002
2020	2019	MAYO CLINIC	200 FIRST ST SW	ROCHESTER	MN	55905	OLMSTED	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	3	9/8/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,036,002

Issue Date FY: 2019 ( Subtotal = $1,058,284 )
2019	2019	MAYO CLINIC	200 FIRST ST SW	ROCHESTER	MN	55905	OLMSTED	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	3	6/21/2019	NON-COMPETING CONTINUATION	$1,058,284
														Subtotal = $1,058,284

Issue Date FY: 2018 ( Subtotal = $1,093,981 )
2018	2018	MAYO CLINIC	200 1ST ST SW	ROCHESTER	MN	55905	OLMSTED	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	2	6/15/2018	NON-COMPETING CONTINUATION	$1,093,981
														Subtotal = $1,093,981

Issue Date FY: 2017 ( Subtotal = $1,149,204 )
2017	2017	MAYO CLINIC	200 1ST ST SW	ROCHESTER	MN	55905	OLMSTED	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	9/18/2017	NEW	$1,149,204
														Subtotal = $1,149,204

Grand Total All Awards = $5,277,550

Top

All Categories

About

Search

Reports

Data Submission

Award Information

High-performance compact 3T MRI: Technical optimization for advanced brain imaging

Award Number: U01EB024450

ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer