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Genome-wide genotyping of existing samples from Asian American and Pacific Islander participants in the California Teachers Study cohort to facilitate broad and open future research

Award Number: U01CA199277
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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PROJECT SUMMARY/ABSTRACT This application is being submitted in response to the Notice of Special Interest (NOSI) identified as NOT-CA- 21-049. Our California Teachers Study (CTS), a cancer epidemiology cohort (CEC), is ideally positioned to help advance the goals of this Notice. We propose to leverage existing biospecimens to increase representation of racial/ethnic minority samples in germline genome-wide genotyping data repositories with accompanying exposure, phenotype, and outcome data; and to broadly share these data with the research community. CTS participants from racial/ethnic minority populations recently donated biospecimens and have provided extensive and broad exposure, phenotype, and outcome data for years. The specimens are currently stored in freezers and can now be genotyped and shared with the community for high-impact and hypothesis- driven research. Biospecimens in large CECs like the CTS are especially valuable because they create opportunities to directly investigate the combined influence of environment, lifestyle, and biomarkers on cancer risks and outcomes. Many CECs today have biospecimens that could be genotyped to create multi-level data that can be used for integrative analyses into cancer risks and outcomes. In this application, we describe three factors that make the CTS especially well qualified to accelerate the NCI's research goals in this area. One, although the CTS is a CEC, the CTS is also more than just a CEC. Since it began, the CTS has used efficient data-linkages with California hospitalization databases to obtain detailed individual-level inpatient, emergency department, and ambulatory surgery outcomes data for all of its participants who have provided blood samples. This means CTS's genotyping data can support not just cancer research projects, but also research on other important chronic diseases (e.g., heart disease, diabetes, and dementia) and health-care endpoints. Two, this application focuses on Asian-American and Pacific Islander (AAPI) CTS participants. As a group, AAPIs are at higher risk of cancer but significantly understudied, especially within CECs. AAPIs are also incredibly diverse, and this makes precise AAPI-focused research a challenge. AAPI phenotypes in the CTS have been characterized in detail and in ways that can help accelerate broad-based genomics research. CTS participants reported their own race/ethnicity and that of both of their parents. Within every AAPI ethnic group, approximately 90% of CTS participants have parents who were from the same AAPI ethnic group; i.e., both parents were Chinese, or were Vietnamese, or were Filipino. This creates a level of precision that will further extend the future range of research that these CTS data can support. Third, the CTS is a leader among CECs in data sharing. Since 2015, we have developed new ways, tools, and infrastructure to share all CTS information and resources with the research community. All of those assets will help ensure the success of this project. The sooner these samples are genotyped, the sooner they can be used by the community for high- impact research projects that promote data sharing and help close gaps in AAPI research.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $1,746,680 )
2023	2023	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1500 DUARTE RD	DUARTE	CA	91010	LOS ANGELES	USA	Environmental Health	001	9	8/30/2023	SUPPLEMENT FOR EXPANSION	$650,629
2023	2023	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1500 DUARTE RD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Cause and Prevention Research	000	9	8/25/2023	NON-COMPETING CONTINUATION	$1,096,051
														Subtotal = $1,746,680

Issue Date FY: 2022 ( Subtotal = $1,573,149 )
2022	2022	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1500 DUARTE RD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Cause and Prevention Research	000	8	8/18/2022	NON-COMPETING CONTINUATION	$1,024,494
2022	2022	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1500 DUARTE RD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Cause and Prevention Research	001	8	9/2/2022	SUPPLEMENT FOR EXPANSION	$199,998
2022	2022	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1500 DUARTE RD	DUARTE	CA	91010	LOS ANGELES	USA	Trans-NIH Research Support	002	8	9/7/2022	SUPPLEMENT FOR EXPANSION	$348,657
														Subtotal = $1,573,149

Issue Date FY: 2021 ( Subtotal = $1,715,958 )
2021	2021	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1500 DUARTE RD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Cause and Prevention Research	004	7	9/8/2021	SUPPLEMENT FOR EXPANSION	$147,430
2021	2021	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1500 DUARTE RD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Cause and Prevention Research	003	7	8/30/2021	NON-COMPETING CONTINUATION	$1,568,528
2021	2020	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1500 DUARTE RD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Cause and Prevention Research	002	6	4/27/2021	COMPETING CONTINUATION	$0
2021	2020	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1500 DUARTE RD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Cause and Prevention Research	001	6	3/8/2021	COMPETING CONTINUATION	$578,473
2021	2019	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1500 DUARTE RD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Cause and Prevention Research	000	5	3/8/2021	NON-COMPETING CONTINUATION	-$578,473
														Subtotal = $1,715,958

Issue Date FY: 2020 ( Subtotal = $1,598,282 )
2020	2020	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1500 DUARTE RD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Cause and Prevention Research	000	6	9/9/2020	COMPETING CONTINUATION	$1,598,282
														Subtotal = $1,598,282

Issue Date FY: 2019 ( Subtotal = $2,501,340 )
2019	2019	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1500 DUARTE RD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Cause and Prevention Research	000	5	8/28/2019	NON-COMPETING CONTINUATION	$2,501,340
														Subtotal = $2,501,340

Issue Date FY: 2018 ( Subtotal = $2,520,260 )
2018	2018	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1500 DUARTE RD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Cause and Prevention Research	000	4	8/28/2018	NON-COMPETING CONTINUATION	$2,520,260
														Subtotal = $2,520,260

Issue Date FY: 2017 ( Subtotal = $2,808,882 )
2017	2017	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1500 DUARTE RD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Cause and Prevention Research	000	3	9/4/2017	NON-COMPETING CONTINUATION	$2,808,882
														Subtotal = $2,808,882

Issue Date FY: 2016 ( Subtotal = $2,817,953 )
2016	2016	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1450 EAST DUARTE ROAD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Cause and Prevention Research	000	2	9/1/2016	NON-COMPETING CONTINUATION	$2,817,953
														Subtotal = $2,817,953

Issue Date FY: 2015 ( Subtotal = $2,499,078 )
2015	2015	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1450 EAST DUARTE ROAD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Cause and Prevention Research	000	1	8/24/2015	NEW	$2,499,078
														Subtotal = $2,499,078

Grand Total All Awards = $19,781,582

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Genome-wide genotyping of existing samples from Asian American and Pacific Islander participants in the California Teachers Study cohort to facilitate broad and open future research

Award Number: U01CA199277

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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