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Neurobiology of Cortical Systems

Award Number: T32NS007224
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

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PROJECT SUMMARY The goal of this proposal is to provide highly focused and advanced training in the development, function and dysfunction of the mammalian cerebral cortex at Yale University. The philosophy of this program is to preserve and foster integrative approaches to neurobiology that will interface across genetics, molecular biology, cell biology, systems neuroscience and clinical medicine with respect to the development, organization, function and plasticity of the mammalian cortex. Twenty-seven (27) faculty from eleven (11) basic and clinical departments at both Yale School of Medicine and Yale College are participants in this multidisciplinary program. The program offers both depth and breadth. The depth derives from its unique substantive focus on cortical circuits of the rodent, primate and human brain. The breadth of the program derives from the diversity of approaches, spanning genetic, molecular, developmental, systems, theory and cognitive neuroscience. Faculty interests span cortical morphogenesis and axon guidance mechanisms in embryos to memory decline and stroke in elderly humans. Methodologies include deep sequencing; cloning; cell culture; immunocytochemistry; in situ hybridization; electron and two photon microscopy; voltage clamp and whole cell recording; calcium and other forms of optical imaging; biochemistry and molecular analyses; psycho-pharmacology; rodent, monkey and human behavior; in vivo extracellular recording in behaving animals; and fMRI and PET imaging in human subjects. Four predoctoral positions are requested. Trainees are selected by the Executive Committee from an outstanding pool of advanced Neuroscience graduate students at Yale, which are amongst the best in the country and come from a variety of backgrounds in biological and physical sciences. Trainees are selected on the basis of their potential for excellence and leadership in research focused on the mammalian neocortex. Mentors are Ph.D.s and M.D.s. with substantial NIH support and NINDS related research foci on the neurobiology of cortical systems, particularly the development, function and dysfunction, including Alzheimer’s, Schizophrenia and Autism. Training includes focused coursework, instruction in experimental design and statistical methods, aggressive mentorship through advisory committees, intensive research apprenticeship, structured seminar programs, career skills development, extensive oral and written feedback, and numerous opportunities for written and oral presentation of research progress and analysis.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $223,878 )
2023	2023	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	NEW HAVEN	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	38	6/30/2023	NON-COMPETING CONTINUATION	$223,878
														Subtotal = $223,878

Issue Date FY: 2022 ( Subtotal = $220,565 )
2022	2022	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	NEW HAVEN	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	37	6/14/2022	NON-COMPETING CONTINUATION	$220,565
2022	2022	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	NEW HAVEN	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	003	37	8/1/2022	NON-COMPETING CONTINUATION	$0
2022	2021	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	NEW HAVEN	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	36	12/27/2021	COMPETING CONTINUATION	$54,483
2022	2020	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	NEW HAVEN	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	35	12/27/2021	NON-COMPETING CONTINUATION	-$54,483
														Subtotal = $220,565

Issue Date FY: 2021 ( Subtotal = $207,472 )
2021	2021	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	NEW HAVEN	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	36	6/24/2021	COMPETING CONTINUATION	$207,472
														Subtotal = $207,472

Issue Date FY: 2020 ( Subtotal = $100,697 )
2020	2020	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	NEW HAVEN	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	35	6/25/2020	NON-COMPETING CONTINUATION	$100,697
														Subtotal = $100,697

Issue Date FY: 2019 ( Subtotal = $191,509 )
2019	2019	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	NEW HAVEN	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	34	6/18/2019	NON-COMPETING CONTINUATION	$191,509
														Subtotal = $191,509

Issue Date FY: 2018 ( Subtotal = $164,397 )
2018	2018	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	NEW HAVEN	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	32	4/24/2018	SUPPLEMENT FOR EXPANSION	-$18
2018	2018	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	NEW HAVEN	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	32	4/20/2018	SUPPLEMENT FOR EXPANSION	$631
2018	2018	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	NEW HAVEN	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	33	6/15/2018	NON-COMPETING CONTINUATION	$163,784
														Subtotal = $164,397

Issue Date FY: 2017 ( Subtotal = $193,710 )
2017	2017	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	NEW HAVEN	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	32	6/7/2017	NON-COMPETING CONTINUATION	$191,688
2017	2017	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	NEW HAVEN	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	32	7/3/2017	NON-COMPETING CONTINUATION	$2,022
														Subtotal = $193,710

Issue Date FY: 2016 ( Subtotal = $166,044 )
2016	2016	YALE UNIVERSITY	47 College Street	NEW HAVEN	CT	06520	NEW HAVEN	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	31	6/20/2016	COMPETING CONTINUATION	$166,044
														Subtotal = $166,044

Issue Date FY: 2014 ( Subtotal = $118,957 )
2014	2014	YALE UNIVERSITY	47 College Street	NEW HAVEN	CT	06520	NEW HAVEN	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	30	6/26/2014	NON-COMPETING CONTINUATION	$648
2014	2014	YALE UNIVERSITY	47 College Street	NEW HAVEN	CT	06520	NEW HAVEN	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	30	6/12/2014	NON-COMPETING CONTINUATION	$118,309
														Subtotal = $118,957

Issue Date FY: 2013 ( Subtotal = $204,096 )
2013	2013	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	NEW HAVEN	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	29	6/3/2013	NON-COMPETING CONTINUATION	$204,096
														Subtotal = $204,096

Issue Date FY: 2012 ( Subtotal = $263,185 )
2012	2012	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	NEW HAVEN	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	28	8/27/2012	SUPPLEMENT FOR EXPANSION	$57,741
2012	2012	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	NEW HAVEN	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	28	4/17/2012	NON-COMPETING CONTINUATION	$205,444
														Subtotal = $263,185

Issue Date FY: 2011 ( Subtotal = $245,876 )
2011	2011	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	NEW HAVEN	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	27	5/16/2011	NON-COMPETING CONTINUATION	$201,472
2011	2011	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	NEW HAVEN	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	27	9/20/2011	SUPPLEMENT FOR EXPANSION	$6,400
2011	2011	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	NEW HAVEN	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	27	9/8/2011	SUPPLEMENT FOR EXPANSION	$38,004
														Subtotal = $245,876

Issue Date FY: 2010 ( Subtotal = $222,857 )
2010	2010	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	NEW HAVEN	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	26	3/22/2010	COMPETING CONTINUATION	$194,907
2010	2010	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	NEW HAVEN	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	26	9/3/2010	SUPPLEMENT FOR EXPANSION	$27,950
														Subtotal = $222,857

Issue Date FY: 2009 ( Subtotal = $69,517 )
2009	2009	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	NEW HAVEN	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	25	5/7/2009	NON-COMPETING CONTINUATION	$0
2009	2009	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	NEW HAVEN	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	25	4/23/2009	NON-COMPETING CONTINUATION	$69,517
														Subtotal = $69,517

Issue Date FY: 2008 ( Subtotal = $189,351 )
2008	2008	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	NEW HAVEN	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	24	6/18/2008	NON-COMPETING CONTINUATION	$189,351
														Subtotal = $189,351

Issue Date FY: 2007 ( Subtotal = $194,159 )
2007	2007	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	NEW HAVEN	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	23	6/7/2007	NON-COMPETING CONTINUATION	$194,159
														Subtotal = $194,159

Issue Date FY: 2006 ( Subtotal = $122,129 )
2006	2006	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	NEW HAVEN	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	21	6/6/2006	SUPPLEMENT FOR EXPANSION	$0
2006	2006	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	NEW HAVEN	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	22	6/23/2006	NON-COMPETING CONTINUATION	$122,129
														Subtotal = $122,129

Issue Date FY: 2004 ( Subtotal = $118,930 )
2004	2004	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	NEW HAVEN	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	20	6/30/2004	NON-COMPETING CONTINUATION	$118,930
														Subtotal = $118,930

Issue Date FY: 2003 ( Subtotal = $221,942 ) (Continued on the next page)
Grand Total All Awards = $4,421,889

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Neurobiology of Cortical Systems

Award Number: T32NS007224

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

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