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Social inequalities and the onset of Alzheimer's pathology: The role of Race/Ethnicity, cognitive reserve, and occupational complexity

Award Number: RF1AG058595
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Abstract Alzheimer's disease and related dementias (ADRD) are the fifth most common cause of death, and the only major cause of death for which there is no prevention or cure. It is thus crucial that we improve our understanding of the etiology of the disease. Social disadvantage likely plays an important role in Alzheimer's, in part because it modifies the risk of risks. Despite theoretical reasoning that social disadvantage should be associated with the risk of ADRD, results from clinical and behavioral studies diverge. We propose to examine whether domains of social inequality are associated with survival rates derived from a novel method that uses accelerated declines in cognitive functioning, which are known to precede ADRD, as a biomarker for the disease. The aims are to examine whether Race/Ethnicity, educational attainment, occupational complexity, and gender/sexuality are indicators of risk of Alzheimer's-related declines. This study further responds to an NIA call to study the role of health disparities in determining risk of ADRD pathology (PA-15-349). This study thus addresses NIA Goal B by improving our understanding of societal factors influencing cognitive decline and the risk of ADRD, and helps to improve our understanding of correlates of ADRD (NIA Goal D). !


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2019	THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK	W5510 FRANKS MELVILLE MEMORIAL LIBRARY	STONY BROOK	NY	11794	SUFFOLK	USA	Aging Research	000	1	2/21/2024	NEW	$0
														Subtotal = $0

Issue Date FY: 2019 ( Subtotal = $3,327,587 )
2019	2019	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	WEST 5510 FRANKS MELVILLE MEMORIAL LIBRARY	STONY BROOK	NY	11794	SUFFOLK	USA	Aging Research	001	1	8/23/2019	NEW	$2,646,234
2019	2019	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	WEST 5510 FRANKS MELVILLE MEMORIAL LIBRARY	STONY BROOK	NY	11794	SUFFOLK	USA	Aging Research	000	1	2/9/2019	NEW	$681,353
														Subtotal = $3,327,587

Grand Total All Awards = $3,327,587

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Social inequalities and the onset of Alzheimer's pathology: The role of Race/Ethnicity, cognitive reserve, and occupational complexity

Award Number: RF1AG058595

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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