Project Summary (Abstract)
Transcranial electrical stimulation (tES) represents a promising, noninvasive methodology by which to test
causal mechanisms of human cognitive brain functions, and to translate systems neuroscience theory into
therapy. This proposal utilizes whole-brain individualized neural modeling to better understand and harness
the causal mechanisms by which tES modulates brain activity dynamics and cognitive functioning. The
proposed research addresses key limitations of previous tES cognitive-enhancement studies, including uncertain
mechanisms, efficacy, and individual variability, by drawing on an explicit neurocomputational architecture from
which to derive strong brain-behavior linkages. In particular, a primary strength of the proposed project is its
utilization of the Mesoscopic Individualized Neurodynamic (MINDy) modeling approach and platform previously
developed and validated by the investigative team. The proposed project provides an ambitious extension of our
prior work, by fully leveraging the MINDy platform to validate and test an innovative neural control engineering
approach for analyzing, predicting, and manipulating causal relationships between large-scale brain networks
(salience [SAL], frontoparietal control [FPN], default mode [DMN]) and their influence on cognitive function. We
build individualized MINDy models for each participant based on their resting-state electroencephalographic
(EEG) data, then further optimize model estimation through a novel closed-loop tES+EEG stimulation
protocol (Aim 1). We then apply MINDy to modulate brain network dynamics associated with attention and
cognitive control, drawing upon the influential triple-network model, by optimally stimulating the SAL network
in a model-guided manner to shift from a DMN-dominant to FPN-dominant mode, under resting-state EEG
conditions (Aim 2). Finally, we extend the stimulation protocol to cognitive task contexts (Aim 3), by
implementing model-guided shifts of FPN-DMN balance as participants perform a well-established experimental
paradigm probing attention and cognitive control (AX-CPT), testing for performance enhancements in terms
of theoretically-interpretable behavioral markers. The findings of this project will have high