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Examining Mortality Risk and Cause of Death among California's Newborn Screening Identified Cohort with Sickle Cell Trait

Award Number: R21HL150454
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary There is growing concern about the possible health effects of positive sickle cell trait carrier status (SCT), with the National Collegiate Athletic Association now requiring testing of all Division I, II, and III athletes before they can play, and special training regimens if players do have SCT. Few large scale studies have been conducted, and epidemiologic investigations have not been conducted for this condition previously thought to be benign. We propose looking at mortality and end of life healthcare utilization for a cohort of approximately 140,000 persons identified in California’s Newborn Screening Program from 1990-2018 as having confirmed SCT. Using validated linking methodology, California Biobank Program (California Department of Public Health) will link these cases and three matched controls per case with California’s Vital Records Death files. These files include date of death and an underlying and three contributing causes of death. A secondary linkage, using Tracking California’s Dynamic Health Data Linkage tool, for those who died will add hospitalization and emergency department records for the last year of life, improving accuracy of specific cause of death for these persons. These data will be used to calculate all-cause mortality risk in the SCT population up to age 28 and to compare causes of death among the case and control populations. Publications, abstracts at major conferences, and health education materials for lay audiences will be developed and distributed with the results of these analyses.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$250 )
2024	2021	PUBLIC HEALTH INSTITUTE	555 12TH ST STE 600	OAKLAND	CA	94607	ALAMEDA	USA	Blood Diseases and Resources Research	000	2	12/4/2023	NON-COMPETING CONTINUATION	-$250
														Subtotal = -$250

Issue Date FY: 2021 ( Subtotal = $89,207 )
2021	2021	PUBLIC HEALTH INSTITUTE	555 12TH ST STE 1050	OAKLAND	CA	94607	ALAMEDA	USA	Blood Diseases and Resources Research	002	2	6/4/2021	NON-COMPETING CONTINUATION	$8,922
2021	2021	PUBLIC HEALTH INSTITUTE	555 12TH ST STE 1050	OAKLAND	CA	94607	ALAMEDA	USA	Blood Diseases and Resources Research	001	2	1/22/2021	NON-COMPETING CONTINUATION	$80,285
2021	2020	PUBLIC HEALTH INSTITUTE	555 12TH ST STE 1050	OAKLAND	CA	94607	ALAMEDA	USA	Blood Diseases and Resources Research	000	1	10/22/2020	NEW	$0
														Subtotal = $89,207

Issue Date FY: 2020 ( Subtotal = $89,207 )
2020	2020	PUBLIC HEALTH INSTITUTE	555 12TH ST STE 1050	OAKLAND	CA	94607	ALAMEDA	USA	Blood Diseases and Resources Research	000	1	2/7/2020	NEW	$89,207
														Subtotal = $89,207

Grand Total All Awards = $178,164

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Examining Mortality Risk and Cause of Death among California's Newborn Screening Identified Cohort with Sickle Cell Trait

Award Number: R21HL150454

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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