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Perinatal Brain Injury: Identifying Cortical Excitability and Circuitry through Multi-Modal Assessment

Award Number: R21HD097575
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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PROJECT SUMMARY/ABSTRACT Early brain injury, caused by stroke, is one of the primary causes of cerebral palsy. Individual lifetime costs of care for an individual with cerebral palsy are estimated at over $1M. Understanding the manner in which the brain recovers after early brain injury, and the impact on resultant motor function, will allow future development of targeted and effective rehabilitation interventions in this uniquely neuroplastic infant population. The first year of life post-injury represents a ‘window of opportunity’ to advance our knowledge of the changes in brain organization and excitability that contribute to motor function. Non-invasive brain stimulation can assess brain excitability and identify patterns of connectivity, or circuitry in the brain, especially as the brain both recovers and develops after a perinatal injury. Brain stimulation can be used therefore to characterize the excitability profiles of the cortical regions contributing to motor output and the circuitry of the descending corticospinal tract originating from these regions. Stimulation can serve as a unique tool to investigate recovery from brain injury complementing current neuroimaging and motor function assessments to predict outcomes. We propose to use one form of non-invasive brain stimulation, transcranial magnetic stimulation (TMS), to assess the excitability and circuitry of motor cortical areas in infants with early brain injury due to stroke. To complement this assessment, we will create individualized computational models of the TMS-induced electric field distribution in the infant brain using individual structural brain anatomy obtained through magnetic resonance imaging. For both infants with perinatal brain injury and age-matched typically-developing controls, we will create complementary computational models of TMS-induced electric fields in each hemisphere, based on individual neuroanatomy obtained from MRI. This combined approach will provide critical information about the structures and pathways activated by TMS, and offer insight into potential targets for future non-invasive brain stimulation interventions. The results from this proposed in this R21 will advance our understanding of infant brain development after perinatal injury by integrating TMS assessment and computational models to predict not only the impact of the stroke on developing motor circuitry but also the response to brain stimulation. We will integrate our findings in future studies comparing excitability and circuitry as variables that may contribute to motor outcomes. By integrating validated computational models of TMS-induced electric fields, we can use individualized anatomical targets for future neuromodulation studies in infants with defined circuitry patterns and develop tailored interventions to improve motor function in infants with early brain injury.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = -$169 )
2023	2020	REGENTS OF THE UNIVERSITY OF MINNESOTA	200 OAK ST SE	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Child Health and Human Development Extramural Research	000	2	7/27/2023	NON-COMPETING CONTINUATION	-$169
														Subtotal = -$169

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2020	REGENTS OF THE UNIVERSITY OF MINNESOTA	200 OAK ST SE # 224	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Child Health and Human Development Extramural Research	000	2	12/13/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $184,538 )
2020	2020	REGENTS OF THE UNIVERSITY OF MINNESOTA	200 OAK ST SE # 224	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Child Health and Human Development Extramural Research	000	2	7/9/2020	NON-COMPETING CONTINUATION	$184,538
														Subtotal = $184,538

Issue Date FY: 2019 ( Subtotal = $223,038 )
2019	2019	REGENTS OF THE UNIVERSITY OF MINNESOTA	200 OAK ST SE # 224	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Child Health and Human Development Extramural Research	000	1	8/3/2019	NEW	$223,038
														Subtotal = $223,038

Grand Total All Awards = $407,407

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Perinatal Brain Injury: Identifying Cortical Excitability and Circuitry through Multi-Modal Assessment

Award Number: R21HD097575

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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