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Low-intensity ultrasound for control of cardiac electromechanics: a mechanistic investigation.

Award Number: R21EB026152
ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Abstract It is estimated that one million cases of syncope and sudden cardiac death are caused by arrhythmias every year in the United States and Europe. Drug therapy is an option for treating arrhythmias however the efficacy of drug treatments vary depending on the location and types of arrhythmia. Further, heart failure is a contraindication for the drugs used to combat arrhythmia which is a problem considering a large portion of people with heart failure also have arrhythmias. Another treatment option for treating arrhythmia is usage of implantable cardioverter defibrillators and pacemakers. The drawbacks to this type of therapies is that they are invasive and can have poor patient acceptance as well as suboptimal outpatient applicability. There is also the potential for pacing devices to malfunction in the presence of a source of electromagnetic energy. Our main hypothesis is that low-intensity non-ablative ultrasound may offer an alternative for modulation of cardiac electrophysiology. Previous studies and our own preliminary results have shown that cardiac pacing via ultrasound may be possible, however only limited sets of ultrasound parameters have been tested so far. Mechanosensitivity of cardiomyocytes and cardiac tissue is well documented, with multiple biological structures engaged in the response. Yet, mechanistically, very few studies have pursued identification of the molecular correlates of cardiomyocyte response to ultrasound, and no mechanistic studies have been done before in human cardiomyocytes. We have two main specific aims which we wish to achieve for testing our hypothesis. Our first specific aim is to find optimal ultrasound parameters to safely and effectively control cardiac electromechanical activity of human cardiomyocytes, including controlling reversible change in pacing rate, initiation and termination of activity. Our second specific aim is to study molecular mechanisms of cardiac electromechanical response to low-intensity ultrasound stimulation. This work can impact the fields of stem cell biology for cardiac repair and personalized medicine. It can also inspire a development of novel ultrasound in vivo rhythm control devices.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = -$62 )
2023	2019	GEORGE WASHINGTON UNIVERSITY (THE)	1918 F ST NW	WASHINGTON	DC	20052	DISTRICT OF COLUMBIA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	2	11/22/2022	NON-COMPETING CONTINUATION	-$62
														Subtotal = -$62

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2019	GEORGE WASHINGTON UNIVERSITY, THE	1918 F ST NW	WASHINGTON	DC	20052	DISTRICT OF COLUMBIA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	2	6/22/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2019 ( Subtotal = $239,250 )
2019	2019	GEORGE WASHINGTON UNIVERSITY, THE	1918 F ST NW	WASHINGTON	DC	20052	DISTRICT OF COLUMBIA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	2	8/26/2019	NON-COMPETING CONTINUATION	$239,250
														Subtotal = $239,250

Issue Date FY: 2018 ( Subtotal = $199,375 )
2018	2018	THE GEORGE WASHINGTON UNIVERSITY	2121 I ST NW STE 601	WASHINGTON	DC	20052	DISTRICT OF COLUMBIA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	9/13/2018	NEW	$199,375
														Subtotal = $199,375

Grand Total All Awards = $438,563

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Low-intensity ultrasound for control of cardiac electromechanics: a mechanistic investigation.

Award Number: R21EB026152

ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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