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Field Shaping Scintillator-coupled High-gain Avalanche Rushing Photoconductor (SHARP) for Active Matrix Flat Panel Imager (AMFPI): Towards Large-Area, High-Efficiency, and Low-Dose X-ray Imaging

Award Number: R21EB025300
ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Abstract The field of medical x-ray imaging experienced a "digital revolution" in the early 2000s, with the spreading of digital radiography (DR) systems which are based on active matrix flat panel imagers (AMFPI). Since then we have seen rapid development and clinical translation of large-area AMFPI based on amorphous silicon (a-Si) active matrix technology. Because of their compact size, rapid image readout and excellent image quality, AMFPI is being used not only for traditional x-ray imaging modalities such as general radiography and fluoroscopy, but also in tomographic imaging applications including cone beam computed tomography (CBCT) and digital tomosynthesis. It is believed that AMFPI will become the dominant detector technology for x-ray imaging. However before AMFPI can equal the performance of the x-ray image intensifier (XRII) in fluoroscopy, they have one major difficulty to overcome: producing x-ray quantum noise limited images at very low dose, such as in the dark part of a fluoroscopy image (0.1 R per frame). Our hypothesis is that an indirect-conversion x-ray flat-panel imager with avalanche gain and cadmium selenide (CdSe) photoelectric conversion layer will provide an enormous dynamic range and efficiency that permits x-ray quantum noise limited performance from a single x-ray photon level in low-dose fluoroscopy all the way to high dose radiography. The objective of this proposal is therefore to fabricate and test a prototype high-efficiency flat-panel x-ray imaging detector with avalanche gain. Conceptually the proposed detector employs four major components: (1) a structured cesium iodide (CsI) scintillator to convert x-rays to optical photons; (2) an ultra-high efficiency CdSe photoelectric conversion layer to convert the optical image to charge; (3) field shaping avalanche amorphous selenium (a-Se) photoconductor, called field shaping HARP (High-gain Avalanche Rushing amorphous Photoconductor), to amplify charge via avalanche multiplication gain; and (4) a large area active matrix (AM) thin film transistor (TFT) array to read out the image electronically in real-time. The proposed detector is known as "field shaping SHARP-AMFPI (Scintillator-HARP Active Matrix Flat-Panel Imager)". Successful development of field-shaping SHARP-AMFPI will lead to the clinical-translation ready, practical low-dose x-ray imaging technology, which will be the first ever large area solid-state detector with stable avalanche gain.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$12,071 )
2024	2020	THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK	W5510 FRANKS MELVILLE MEMORIAL LIBRARY	STONY BROOK	NY	11794	SUFFOLK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	3	10/19/2023	NON-COMPETING CONTINUATION	-$12,071
														Subtotal = -$12,071

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2020	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	WEST 5510 FRANKS MELVILLE MEMORIAL LIBRARY	STONY BROOK	NY	11794	SUFFOLK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	3	2/23/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2020	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	WEST 5510 FRANKS MELVILLE MEMORIAL LIBRARY	STONY BROOK	NY	11794	SUFFOLK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	3	4/20/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $236,758 )
2020	2020	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	WEST 5510 FRANKS MELVILLE MEMORIAL LIBRARY	STONY BROOK	NY	11794	SUFFOLK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	3	1/14/2020	NON-COMPETING CONTINUATION	$236,758
														Subtotal = $236,758

Issue Date FY: 2019 ( Subtotal = $157,008 )
2019	2019	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	WEST 5510 FRANKS MELVILLE MEMORIAL LIBRARY	STONY BROOK	NY	11794	SUFFOLK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	2	12/20/2018	NON-COMPETING CONTINUATION	$157,008
														Subtotal = $157,008

Issue Date FY: 2018 ( Subtotal = $236,394 )
2018	2018	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	WEST 5510 FRANKS MELVILLE MEMORIAL LIBRARY	STONY BROOK	NY	11794	SUFFOLK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	1	1/4/2018	NEW	$0
2018	2018	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	WEST 5510 FRANKS MELVILLE MEMORIAL LIBRARY	STONY BROOK	NY	11794	SUFFOLK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	12/27/2017	NEW	$236,394
														Subtotal = $236,394

Grand Total All Awards = $618,089

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Field Shaping Scintillator-coupled High-gain Avalanche Rushing Photoconductor (SHARP) for Active Matrix Flat Panel Imager (AMFPI): Towards Large-Area, High-Efficiency, and Low-Dose X-ray Imaging

Award Number: R21EB025300

ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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