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Defining specific mechanisms limiting oxygen delivery and utilization in heart failure with preserved ejection fraction: Novel insight from Near-Infrared Diffuse Correlation Spectroscopy

Award Number: R15HL140989
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary Exercise intolerance is the hallmark symptom in patients with heart failure with preserved ejection fraction. As a consequence, activities of daily living require near maximal effort, resulting in further deconditioning and reduced quality of life. While the exact mechanism for the exercise intolerance remains unclear, emerging evidence from our group and others, suggests that impairments in skeletal muscle oxygen delivery and utilization contribute significantly. However, no study to date has simultaneously measured skeletal muscle blood flow and oxidative metabolism in a single subject; making it difficult to assign causality or priority. Broadband near-infrared diffuse correlation spectroscopy (bbNIRS/DCS) has the potential to address this specific limitation, by simultaneously assessing skeletal muscle microvascular perfusion, oxygenation, and mitochondrial function in a single non- invasive imaging session. We are therefore seeking funding to construct and validate a bbNIRS/DCS hybrid system to quantify skeletal muscle perfusion and metabolic function in vivo. Once established, we will extend this novel technology to patients with HFpEF, in order to define specific mechanisms contributing to impaired peripheral oxygen utilization. Together, these studies will not only establish one of the most comprehensive imaging tools for assessing peripheral oxygen delivery and utilization, but will also provide new mechanistic insight into peripheral limitations to exercise in HFpEF.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = -$17,646 )
2023	2018	THE UNIVERSITY OF TEXAS AT ARLINGTON	701 S. NEDDERMAN DR	ARLINGTON	TX	76019	TARRANT	USA	Cardiovascular Diseases Research	000	1	8/21/2023	NEW	-$17,646
														Subtotal = -$17,646

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2018	UNIVERSITY OF TEXAS AT ARLINGTON	400 S CORN ST	ARLINGTON	TX	76019	TARRANT	USA	Cardiovascular Diseases Research	000	1	11/30/2021	NEW	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2018	UNIVERSITY OF TEXAS AT ARLINGTON	400 S CORN ST	ARLINGTON	TX	76019	TARRANT	USA	Cardiovascular Diseases Research	000	1	2/8/2021	NEW	$0
														Subtotal = $0

Issue Date FY: 2018 ( Subtotal = $441,020 )
2018	2018	UNIVERSITY OF TEXAS AT ARLINGTON	400 S CORN ST	ARLINGTON	TX	76019	TARRANT	USA	Cardiovascular Diseases Research	000	1	1/5/2018	NEW	$441,020
														Subtotal = $441,020

Grand Total All Awards = $423,374

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Defining specific mechanisms limiting oxygen delivery and utilization in heart failure with preserved ejection fraction: Novel insight from Near-Infrared Diffuse Correlation Spectroscopy

Award Number: R15HL140989

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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