ABSTRACT
Support is requested for a Keystone Symposia conference entitled Precision Engineering of the Genome,
Epigenome and Transcriptome, organized by Drs. Charles Gersbach, Rachel E. Haurwitz and Fyodor D.
Urnov. The conference will be part of Keystone Symposia’s eSymposia Conference Series, which are virtual
events. The dates for this online conference will be March 7-11, 2021.
Over the last several years, new genome engineering tools have revolutionized the ability to interrogate
biological systems, engineer innovative biotechnologies, and model and treat human disease. The genome
engineering field continues to evolve at a frenzied pace, including both the development of new fundamental
tools and their application to addressing societal needs. This Keystone Symposia conference will cover this
spectrum of advances, including the most recent technological innovations in genome, epigenome, and
transcriptome precision engineering. The conference will also highlight recent advances in developing human
therapeutics with these tools, including emerging clinical trial results and preclinical examples of novel modes
of intervention. The conference will include a variety of topics of interest to the broad research community,
including next-generation applications such as high-throughput screening, synthetic biology, and chromatin
and RNA imaging and diagnostics. Finally, the conference will conclude with examples of how emerging
technologies can be integrated for an unprecedented level of resolution of cellular processes, such as genome
engineering combined with single-cell analysis methods. Collectively, this meeting will build on its history of
success by familiarizing the audience with the latest advances in tool development, providing an update on
clinical application of these tools, and generating an appreciation for the breadth of scientific areas impacted by
the Genome Engineering Revolution.