ABSTRACT
Support is requested for a Keystone Symposia conference entitled Gene Regulation: From Mechanisms to
Disease, organized by Drs. Karen Adelman and Patrick Cramer. The conference will be held in Keystone,
Colorado from January 26-30, 2020.
Organismal development, homeostasis and healthy aging all rely on precise control of gene expression
programs. Recent technological advances in structural biology, real-time imaging, and next generation
sequencing have shed new light on decades-old questions about gene regulation, and we seek to highlight
these advances. This meeting aims to bring together pioneers in cryoEM, single-cell microscopy, single cell
sequencing and three-dimensional genome architecture, with leading experts in transcriptional regulation, to
seed new collaborations and discoveries. This conference provides an ideal environment to foster interactions
between transcriptional biologists and experts in single cell imaging and genomic approaches and spur
conversations about how to interweave new techniques for structural biology with our growing appreciation that
many critical interactions involve intrinsically disordered domains (which are by definition not well behaved in
most structural approaches). Participants will attend sessions that critically evaluate the impact of genome
organization on gene expression. The conference will also expose trainees to the best science possible and
instill in them the enthusiasm we feel for the future of the field. Finally, pairing of this meeting with Cancer
Epigenetics is ideal as the topics are inherently related. This allows our meeting to focus on underlying
mechanisms and normal developmental systems, while enabling the audience to attend lectures in gene
dysregulation in cancer. We plan two joint sessions to maximize interactions.