Abstract
The specific aim of this proposal is to obtain partial funding for the expenses (travel and lodging) for
junior investigators, postdoctoral fellows and graduate students from the USA to attend the 9th
International Meeting on Epithelial-Mesenchymal Transition. The meeting will be held November 11-
14, 2019 in the Centennial Memorial Hall at University of Kumamoto, Kumamoto, Japan under the
auspices of the Epithelial-Mesenchymal Transition International Association (TEMTIA).
The objectives of the meeting are to 1. Bring together investigators in the separate disciplines of
cancer, pathology and development to discuss their observations on EMT and explore whether there
is a consensus on important components of the process. 2. Provide a forum where students and
junior investigators can interact with senior investigators and display their own work and ideas in the
field. 3. Expand a viable co-operative crossdisciplinary forum of EMT-related researchers
internationally. This will continue to provide a worldwide network for exchange of expertise, reagents
and techniques across disciplines. 4. Publish a timely meeting update on cellular, molecular and
genetic aspects of EMT in an appropriate cross-disciplinary international journal.
Epithelial-mesenchymal transition (EMT) is a fundamental cellular process undertaken by cells in the
embryo to form 3-dimensional structures from sheets of cells. During EMT, epithelial cells lose
adherence to adjacent cells, degrade the local basement membrane and invade the underlying
interstitial extracellular matrix. At the cellular level, this process requires specific signal transduction
elements, new gene transcription, reorganization of the cytoskeleton, secretion of extracellular matrix
molecules and growth factors. In the embryo, this process is reiterated at gastrulation, neural crest
cell formation, somite breakdown, pancreatic islet formation, heart valve formation brain organization
and in several other areas of organogenesis. In the adult, EMT occurs as a component of wound
healing and in the pathologies of cancer metastasis and tissue fibrosis.