ABSTRACT
This proposal seeks funding to support a symposium, Abiotic-Biotic Interfaces for Ophthalmology (ABI), which
will bring together recognized world experts in clinical, research, vision science, engineering, industrial and
pharmaceutical communities as well as junior investigators (i.e., young faculty and those in training) to discuss
the current state of ABI, ranging from bioelectronic implantable and wearable devices, to nanoscale scaffolds for
stem cell and gene therapies. Given the multidisciplinary nature of this field, it is essential to bring together
researchers and clinicians with varying levels of expertise across many domains related to ABI to advance the
progress of this novel field, identify challenges of advancement, and develop a strategic action plan to overcome
these challenges.
The timing to have such a symposium to further the application of implantable and/or wearable bioengineered
systems in ophthalmology is now as we focus on precision and personalized medicine and leverage the
revolution in deep learning artificial intelligence algorithms. Through symposium talks, sessions, and discussions
we will cover the fundamentals and also identify innovative and cutting-edge strategies and methodologies to
accelerate the rate of major discoveries and development of novel therapeutics. The specific aims of this
symposium are:
Specific Aim 1. To bring together both established and junior investigators representing a broad range of
disciplines to discuss cutting edge research in this novel field, catalyze the development of cross-disciplinary
and translational approaches to advance abiotic-biotic interfaces for ophthalmology, and identify gaps in
knowledge and barriers to advancement. We will identify research questions and develop an agenda to guide
future research that is consistent with the objectives and interests of NEI.
Specific Aim 2. Develop a junior investigator program to motivate a diverse group of students and junior
investigators to pursue research careers in vision science and ophthalmologic therapeutic development, who will
ultimately submit grant proposals to NEI solicitations and contribute to the scientific literature.
Specific Aim 3. Develop a strategic action plan to set priorities for future studies that will encourage inter-agency
collaborations (e.g., NEI, NSF, DARPA, etc.). This is critical because often certain engineering tasks are best
suited to be supported by NSF or DARPA whereas the biological testing of the engineered systems lends itself
to funding from NEI. Hence such inter-agency or cross-agency efforts can help leverage the funding to develop
sophisticated abiotic-biotic systems