ABSTRACT
Support is requested for a Keystone Symposia conference entitled Natural Products and Synthetic Biology:
Parts and Pathways, organized by Drs. Jon C. Clardy, Yi Tang and Sean F. Brady. The conference will be
held January 21 - 24, 2018 in Olympic Valley, California.
Natural products, the structurally diverse family of small molecules produced by living organisms in an
idiosyncratic fashion, have provided the basis for the majority of our therapeutic agents used to treat infectious
diseases, cancer and immune disorders. Whole genome sequencing of producing organisms, especially bacteria
and fungi, reveals that we have discovered only a fraction of these biosynthetically derived small molecules; a
substantial fraction of natural product chemical space still represents “dark matter” (i.e., molecules predicted by
bioinformatics analysis that have yet to be observed experimentally). Diversity springs from variations in
genetically encoded biosynthetic enzymes, environmental stimuli that regulate expression of these genes and
the inherent combinatorial expansion resulting from multi-enzyme biosynthetic pathways. Closing this gap
between our current inventory and the genomic potential has become an important goal for basic and applied
science; synthetic biology coupled with bioinformatic analysis has become the primary research tool for this
effort. Bioinformatic mining continues to reveal the enzymes and pathways that nature uses, and synthetic
biology has begun to reassemble or refactor these pathways to produce known and unknown products in new
hosts. This conference brings together researchers in fields ranging from microbiology to botany, bioinformatics,
gene synthesis and assembly, covering the spectrum from basic to industrial applications.