ABSTRACT
Support is requested for a Keystone Symposia conference entitled Molecular Approaches to Vaccines and
Immune Monitoring, organized by Drs. Peter D. Kwong, Brandon DeKosky, and Jeffrey B. Ulmer. The
conference will be held in Keystone, Colorado from February 10-14, 2019.
Vaccines address public health issues ranging from pandemic outbreaks to childhood disease. Despite this
diversity, molecular approaches are beginning to find broad application. This Keystone Symposia conference
seeks to bring together antibody aficionados, B cell immunologists, structural biologists, and vaccine developers
from government, academia, biotechnology, and major pharmaceutical companies to review the utility of
structure-based vaccine design and antibody-based immune monitoring, and in doing so hope to transform
standard approaches of vaccine development. This meeting aims (1) to provide examples of the ”antibody-to-
vaccine” paradigm for RSV, CMV and other pathogens that have resisted standard vaccinology; (2) to describe
procedures whereby B cells can be taught to make the right antibodies; (3) to describe molecular approaches
for vaccine improvement; and (4) to discuss how molecular approaches can be used to speed development (as
may be needed, for example, in the case of pandemics) and to reduce developmental and regulatory costs (for
vaccines in general and in particular to enable provision to the developing world). Overall, we seek to integrate
molecular approaches for vaccine development and read-out with other transformative advances including
mRNA delivery, next-generation sequencing of B cell transcripts, and control of B cell-T cell interactions. This
conference will be held jointly with a Keystone Symposia conference on B Cell-T Cell Interactions and several
shared sessions will highlight synergistic areas of research between these communities.