Thursday, April 25, 2024 4/25/2024

Application of single-cell trajectory analysis in single-cell transcriptomics to elucidate the biology of lung pericytes in injury, repair, and regeneration

Award Number: R03HL155075
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Group Awards By Issue Date FY or Funding FY:

View Award Abstract

ABSTRACT Pericytes have been implicated in inflammation and fibrosis in a number of organs. Data from transcriptomic analyses of activated cultured lung pericytes reveal upregulation of multiple biological pathways including inflammation, angiogenic processes, and cell migration. The goal of this project is to understand the functional plasticity of lung pericytes throughout injury and in lung repair. We are interested in how lung pericytes modulate lung repair in lung fibrosis through angiogenesis and myofibroblast differentiation. In Aim 1, we propose to use state-of-the-art single cell trajectory analysis on single-cell transcriptomic data to describe the cell fate of lung pericytes from acute lung injury to fibrosis. In Aim 2, we propose to study selected stromal subpopulations derived from pericytes and non-pericyte-derived myofibroblasts during fibrosis to examine their functional differences ex vivo.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $88,250 )
2023	2023	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Lung Diseases Research	000	2	12/2/2022	NON-COMPETING CONTINUATION	$88,250
														Subtotal = $88,250

Issue Date FY: 2022 ( Subtotal = $88,250 )
2022	2022	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Lung Diseases Research	000	1	12/14/2021	NEW	$88,250
2022	2022	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Lung Diseases Research	001	1	9/26/2022	NEW	$0
														Subtotal = $88,250

Grand Total All Awards = $176,500

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Application of single-cell trajectory analysis in single-cell transcriptomics to elucidate the biology of lung pericytes in injury, repair, and regeneration

Award Number: R03HL155075

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer