Tuesday, April 16, 2024 4/16/2024

Myometrial artery potassium channel activity in intrauterine growth restriction pregnancy

Award Number: R03HD101659
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Group Awards By Issue Date FY or Funding FY:

View Award Abstract

PROJECT SUMMARY Intrauterine growth restriction (IUGR) increases the risk of stillbirth and neonatal death. The adverse effects of being born IUGR extend well beyond the perinatal period, increasing the risk of cardiovascular disease, among others, in later life. Currently, no effective strategies exist to prevent or treat IUGR. Our overarching goal is to determine the role of K+ channels and intracellular Ca2+ in the regulation of myometrial artery vasoreactivity, both important contributors to uteroplacental perfusion, and, in turn, fetal growth. We expect that two of the most prevalent K + channels in uterine vasculature, BK Ca and K ATP channels, will be impaired in IUGR pregnancy, in association with reduced MA vasorelaxation and fetal growth. To address this goal, we propose to conduct two integrated scientific aims. In Aim 1, we will determine whether (1) the vasodilatory role of BKCa and/or KATP channels is diminished in myometrial arteries from IUGR pregnancies compared to uncomplicated pregnancies; (2) K+ currents mediated by BKCa and/or KATP channels are reduced in myometrial artery smooth muscle cells from IUGR compared to uncomplicated pregnancies; and (3) IUGR impairs the protein expression and/or localization of these channels in myometrial arteries and placenta. Aim 2 will address the role of store- operated Ca2+ entry and intracellular Ca2+ stores in myometrial arteries from IUGR by asking whether myometrial artery smooth muscle cells from IUGR pregnancies show dysregulated store-operated Ca2+ entry and/or intracellular Ca2+ stores. Participants will be women with uncomplicated or IUGR pregnancies. Scientifically, the work proposed is vital to improving our understanding of the mechanisms underlying the reduced uteroplacental blood flow observed in IUGR pregnancies. Our proposed project also has potentially important clinical implications; in particular, our study outcomes may identify novel therapeutic targets to treat or prevent IUGR.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$1,568 )
2024	2022	THE REGENTS OF THE UNIVERSITY OF COLORADO	13001 E 17TH PL STE F428	AURORA	CO	80045	ADAMS	USA	Child Health and Human Development Extramural Research	000	2	4/4/2024	NON-COMPETING CONTINUATION	-$1,568
														Subtotal = -$1,568

Issue Date FY: 2022 ( Subtotal = $77,750 )
2022	2022	REGENTS OF THE UNIVERSITY OF COLORADO, THE	13001 E 17TH PLACE F428	AURORA	CO	80045	ADAMS	USA	Child Health and Human Development Extramural Research	000	2	12/9/2021	NON-COMPETING CONTINUATION	$69,975
2022	2022	REGENTS OF THE UNIVERSITY OF COLORADO, THE	13001 E 17TH PLACE F428	AURORA	CO	80045	ADAMS	USA	Child Health and Human Development Extramural Research	001	2	4/18/2022	NON-COMPETING CONTINUATION	$7,775
														Subtotal = $77,750

Issue Date FY: 2021 ( Subtotal = $77,750 )
2021	2021	REGENTS OF THE UNIVERSITY OF COLORADO, THE	13001 E 17TH PLACE F428	AURORA	CO	80045	ADAMS	USA	Child Health and Human Development Extramural Research	000	1	11/25/2020	NEW	$77,750
														Subtotal = $77,750

Grand Total All Awards = $153,932

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Myometrial artery potassium channel activity in intrauterine growth restriction pregnancy

Award Number: R03HD101659

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer