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Central & peripheral body temperature in VLBW preterm infants during the neonatal period: Relationship to neonatal infection and necrotizing enterocolitis

Award Number: R01NR017872
ORGANIZATION: NATIONAL INSTITUTE OF NURSING RESEARCH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Central & peripheral body temperature in VLBW preterm infants during the neonatal period: Relationship to neonatal infection and necrotizing enterocolitis Objective: We will measure continuous abdominal temperatures (AT) and foot temperatures (FT) in 440 preterm infants from five neonatal units over 28 days to predict occurrence of infection. Abnormal values of the central-peripheral temperature difference (CpTD), greater than 2º and less than 0, are a sign of autonomic instability occurring during infection. We will model the temporal relationship between abnormal CpTD values and the diagnosis of infection to find the best predictive model to use continuous temperature monitoring as a non-invasive, inexpensive predictive monitoring tool for infection. For comparison, we will measure continuous heart rate characteristics (HRC) from a HeRO monitor which predicts infection in preterm infants using heart rate variability. Predictive models of CpTD and HRC will be compared and combined to find the optimal predictive monitoring tool for infection in our sample. We will examine covariates of infants' demographic factors, maternal obstetrical histories, and infants' clinical context for interaction effects between our predictors of CpTD and HRC for infection. Methods: Infants will be enrolled from five NICUs in North and South Carolina. Research nurses or site PIs will obtain parental consent for infants to be enrolled up to 6 hours of age, if they are less than 32 weeks gestational age and less than 1500 grams at birth. Study personnel will attach a thermistor to the sole of the foot and to the abdomen for each study infant. Thermistors will be attached to a data logger which will measure temperature every minute for the first 28 days of life. A HeRO monitor will be attached to each infant's standard cardiopulmonary monitor and a USB drive in the HeRO monitor will collect hourly HRC scores for 28 days. Maternal obstetrical history, infant demographics and infant clinical context variables will be entered into a RedCap data base to be analyzed with physiological data. Data management and analyses will be conducted at University of South Carolina, College of Nursing. Data Analysis: Our interest for this study is the CpTD (AT-FT=CpTD). We will investigate that measure as two derived variables HTD (number/percentage of minutes with CpTd>2) and NTD (number/percentage of minutes with CpTD<0) which are continuous variables. Predictive models will be built utilizing HTD and NTD information defined over various lengths of preceding time (24 to 72 hours) to ultimately yield the optimal predictive model for diagnosis of infection based on CpTD. Our predictive model will be compared to the HRC model utilizing a Monte Carlo cross-validation approach in which we use 70% of the data for training and 30% for validation. Finally, we will combine the HRC predictive covariates to the CpTD covariates to investigate whether the combined model offers further improvements to prediction. If our CpTD predictive model improves the HRC model, it will serve as the foundation of a subsequent proposal to validate the CpTD predictive with new data.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$34,186 )
2025	2022	UNIVERSITY OF SOUTH CAROLINA	1600 HAMPTON ST	COLUMBIA	SC	29208	RICHLAND	USA	Nursing Research	000	5	10/22/2024	NON-COMPETING CONTINUATION	-$34,186
														Subtotal = -$34,186

Issue Date FY: 2022 ( Subtotal = $570,779 )
2022	2022	UNIVERSITY OF SOUTH CAROLINA	1600 HAMPTON ST # 414	COLUMBIA	SC	29208	RICHLAND	USA	Nursing Research	000	5	6/21/2022	NON-COMPETING CONTINUATION	$570,779
														Subtotal = $570,779

Issue Date FY: 2021 ( Subtotal = $539,599 )
2021	2021	UNIVERSITY OF SOUTH CAROLINA	1600 HAMPTON ST # 414	COLUMBIA	SC	29208	RICHLAND	USA	Nursing Research	000	4	5/21/2021	NON-COMPETING CONTINUATION	$539,599
														Subtotal = $539,599

Issue Date FY: 2020 ( Subtotal = $537,050 )
2020	2020	UNIVERSITY OF SOUTH CAROLINA	1600 HAMPTON ST # 414	COLUMBIA	SC	29208	RICHLAND	USA	Nursing Research	000	3	7/1/2020	NON-COMPETING CONTINUATION	$537,050
														Subtotal = $537,050

Issue Date FY: 2019 ( Subtotal = $571,336 )
2019	2019	UNIVERSITY OF SOUTH CAROLINA	1600 HAMPTON ST # 414	COLUMBIA	SC	29208	RICHLAND	USA	Nursing Research	001	2	6/14/2019	NON-COMPETING CONTINUATION	$571,336
2019	2018	UNIVERSITY OF SOUTH CAROLINA	1600 HAMPTON ST # 414	COLUMBIA	SC	29208	RICHLAND	USA	Nursing Research	000	1	11/14/2018	NEW	$0
														Subtotal = $571,336

Issue Date FY: 2018 ( Subtotal = $674,636 )
2018	2018	UNIVERSITY OF SOUTH CAROLINA	1600 HAMPTON ST # 414	COLUMBIA	SC	29208	RICHLAND	USA	Nursing Research	000	1	9/26/2018	NEW	$674,636
														Subtotal = $674,636

Grand Total All Awards = $2,859,214

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Central & peripheral body temperature in VLBW preterm infants during the neonatal period: Relationship to neonatal infection and necrotizing enterocolitis

Award Number: R01NR017872

ORGANIZATION: NATIONAL INSTITUTE OF NURSING RESEARCH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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