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Multimodal Developmental Neurogenetics of Females with ASD

Award Number: R01MH100028
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Group Awards By Issue Date FY or Funding FY:

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Project Summary Autism Spectrum Disorder (ASD) disproportionately affects males (¿) over females (¿), possibly because of a Female Protective Effect (FPE). Characterizing the FPE may help us to understand and treat ASD in both sexes. Our Network has contributed to understanding sex differences in ASD at the levels of gene structure and expression, neural dynamics, brain function and connectivity. We have curated an unprecedented sex-balanced, age-, IQ- and severity-matched cohort of cognitively-able school-age ¿, and ¿ with ASD, age- and IQ-matched typically developing (TD) children and unaffected siblings (US). At T1, we conducted behavioral phenotyping and measured key neural systems at the levels of brain structure, connectivity, function and temporal dynamics. Genotyping, whole-genome sequencing and gene expression analyses are underway. We now seek to pursue an extraordinary opportunity to assess our participants again (T2) as they make the transition through adolescence and into young adulthood. Our field has failed to generate a sufficient knowledge base to help optimize this transition for people living with ASD and their families. We will leverage the expertise of our Network to identify sex differences in ASD longitudinal brain development during this important transition. We will clarify both temporal and spatial characteristics of developing social perception, emotion regulation, reward and implicit language learning circuits, in addition to neural mechanisms for sensory habituation, creating dimensional, multi- level neural signatures of brain development. We will bridge DNA sequence and brain development and relate neural signatures to behavior and genetics to predict “real-world” functioning in young adulthood. We will combine multiple levels of biology and endophenotypes—SNVs, CNVs, clinical measures, pubertal status, presence of seizures/epilepsy, sex hormones and multimodal, longitudinal measures of brain development—into one framework using an Integrated Weighted Gene Coexpression Network Analysis (iWGCNA). Finally, we will extend our T1 systems-biology approach through a collaboration*with ASD self-advocates/participants to evaluate the experiential validity of our findings. The proposed research marks the start of a new era in which advanced multimodal neuroimaging and genetic analyses will evolve into an integral part of a translational research chain. Novel behavioral treatment and pharmacotherapies for ASD may be further developed in adolescence and young adulthood with the tremendous benefit of directly and more precisely assessing impairment and change in neural circuits. By providing information about distinct, sex/gender-based developmental pathways in ASD, this study will identify if intervention/prevention strategies should include sex-based modifications.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $2,447,365 )
2023	2023	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Mental Health Research Grants	003	13	6/26/2023	NON-COMPETING CONTINUATION	$2,447,365
2023	2023	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Mental Health Research Grants	004	13	7/12/2023	NON-COMPETING CONTINUATION	$0
2023	2022	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 EMMET ST N	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Mental Health Research Grants	002	12	5/2/2023	COMPETING CONTINUATION	$2,370,015
2023	2021	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 EMMET ST N	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Mental Health Research Grants	001	11	5/2/2023	NON-COMPETING CONTINUATION	-$2,281,273
2023	2020	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 EMMET ST N	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Mental Health Research Grants	000	10	5/2/2023	NON-COMPETING CONTINUATION	-$88,742
														Subtotal = $2,447,365

Issue Date FY: 2022 ( Subtotal = $2,558,232 )
2022	2022	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Mental Health Research Grants	001	12	9/6/2022	COMPETING CONTINUATION	$2,558,232
2022	2021	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Mental Health Research Grants	000	11	9/6/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,558,232

Issue Date FY: 2021 ( Subtotal = $2,281,273 )
2021	2021	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Mental Health Research Grants	000	11	8/2/2021	NON-COMPETING CONTINUATION	$2,281,273
														Subtotal = $2,281,273

Issue Date FY: 2020 ( Subtotal = $2,299,081 )
2020	2020	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Mental Health Research Grants	000	10	8/3/2020	NON-COMPETING CONTINUATION	$2,299,081
														Subtotal = $2,299,081

Issue Date FY: 2019 ( Subtotal = $2,315,173 )
2019	2019	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Mental Health Research Grants	008	9	8/21/2019	NON-COMPETING CONTINUATION	$2,315,911
2019	2018	GEORGE WASHINGTON UNIVERSITY, THE	1918 F ST NW	WASHINGTON	DC	20052	DISTRICT OF COLUMBIA	USA	Mental Health Research Grants	002	7	4/30/2019	NON-COMPETING CONTINUATION	-$2,338,691
2019	2018	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Mental Health Research Grants	005	8	5/10/2019	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
2019	2018	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Mental Health Research Grants	007	8	6/4/2019	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$1,580,451
2019	2018	GEORGE WASHINGTON UNIVERSITY, THE	1918 F ST NW	WASHINGTON	DC	20052	DISTRICT OF COLUMBIA	USA	Mental Health Research Grants	001	7	3/4/2019	NON-COMPETING CONTINUATION	-$93,500
2019	2018	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Mental Health Research Grants	003	8	4/30/2019	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$2,337,953
2019	2018	GEORGE WASHINGTON UNIVERSITY, THE	1918 F ST NW	WASHINGTON	DC	20052	DISTRICT OF COLUMBIA	USA	Mental Health Research Grants	004	7	5/10/2019	NON-COMPETING CONTINUATION	$0
2019	2017	GEORGE WASHINGTON UNIVERSITY, THE	1918 F ST NW	WASHINGTON	DC	20052	DISTRICT OF COLUMBIA	USA	Mental Health Research Grants	006	6	6/4/2019	COMPETING CONTINUATION	-$1,580,451
2019	2016	GEORGE WASHINGTON UNIVERSITY, THE	1918 F ST NW	WASHINGTON	DC	20052	DISTRICT OF COLUMBIA	USA	Mental Health Research Grants	000	5	3/4/2019	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$93,500
														Subtotal = $2,315,173

Issue Date FY: 2018 ( Subtotal = $2,338,691 )
2018	2018	THE GEORGE WASHINGTON UNIVERSITY	2121 I ST NW STE 601	WASHINGTON	DC	20052	DISTRICT OF COLUMBIA	USA	Mental Health Research Grants	004	7	7/25/2018	NON-COMPETING CONTINUATION	$2,338,691
2018	2017	THE GEORGE WASHINGTON UNIVERSITY	2121 I ST NW STE 601	WASHINGTON	DC	20052	DISTRICT OF COLUMBIA	USA	Mental Health Research Grants	001	6	3/9/2018	COMPETING CONTINUATION	$1,274,738
2018	2017	THE GEORGE WASHINGTON UNIVERSITY	2121 I ST NW STE 601	WASHINGTON	DC	20052	DISTRICT OF COLUMBIA	USA	Mental Health Research Grants	003	6	3/27/2018	COMPETING CONTINUATION	-$110,244
2018	2016	THE GEORGE WASHINGTON UNIVERSITY	2121 I ST NW STE 601	WASHINGTON	DC	20052	DISTRICT OF COLUMBIA	USA	Mental Health Research Grants	002	5	3/27/2018	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$110,244
2018	2016	THE GEORGE WASHINGTON UNIVERSITY	2121 I ST NW STE 601	WASHINGTON	DC	20052	DISTRICT OF COLUMBIA	USA	Mental Health Research Grants	000	5	3/9/2018	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	-$1,274,738
														Subtotal = $2,338,691

Issue Date FY: 2017 ( Subtotal = $2,447,465 )
2017	2017	THE GEORGE WASHINGTON UNIVERSITY	2121 I ST NW STE 601	WASHINGTON	DC	20052	DISTRICT OF COLUMBIA	USA	Mental Health Research Grants	003	6	9/7/2017	COMPETING CONTINUATION	$2,447,465
2017	2016	THE GEORGE WASHINGTON UNIVERSITY	2121 I ST NW STE 601	WASHINGTON	DC	20052	DISTRICT OF COLUMBIA	USA	Mental Health Research Grants	001	5	10/24/2016	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$1,010,466
2017	2016	THE GEORGE WASHINGTON UNIVERSITY	2121 I ST NW STE 601	WASHINGTON	DC	20052	DISTRICT OF COLUMBIA	USA	Mental Health Research Grants	002	5	8/31/2017	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
2017	2015	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	NEW HAVEN	USA	Mental Health Research Grants	000	4	10/24/2016	NON-COMPETING CONTINUATION	-$1,010,466
														Subtotal = $2,447,465

Issue Date FY: 2016 ( Subtotal = $2,525,159 )
2016	2016	GEORGE WASHINGTON UNIVERSITY	44983 KNOLL SQUARE	ASHBURN	VA	20147	LOUDOUN	USA	Mental Health Research Grants	001	5	9/2/2016	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$2,525,159
2016	2015	YALE UNIVERSITY	47 College Street	NEW HAVEN	CT	065208047	NEW HAVEN	USA	Mental Health Research Grants	000	4	9/2/2016	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,525,159

Issue Date FY: 2015 ( Subtotal = $2,703,126 )
2015	2015	YALE UNIVERSITY	47 College Street	NEW HAVEN	CT	06520	NEW HAVEN	USA	Mental Health Research Grants	000	4	7/25/2015	NON-COMPETING CONTINUATION	$2,703,126
														Subtotal = $2,703,126

Issue Date FY: 2014 ( Subtotal = $2,738,896 )
2014	2014	YALE UNIVERSITY	47 College Street	NEW HAVEN	CT	06520	NEW HAVEN	USA	Mental Health Research Grants	000	3	7/3/2014	NON-COMPETING CONTINUATION	$2,738,896
														Subtotal = $2,738,896

Issue Date FY: 2013 ( Subtotal = $2,670,192 )
2013	2013	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	NEW HAVEN	USA	Mental Health Research Grants	000	2	8/20/2013	NON-COMPETING CONTINUATION	$2,670,192
														Subtotal = $2,670,192

Issue Date FY: 2012 ( Subtotal = $3,118,985 )
2012	2012	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	NEW HAVEN	USA	Mental Health Research Grants	000	1	9/4/2012	NEW	$3,118,985
														Subtotal = $3,118,985

Grand Total All Awards = $30,443,638

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Multimodal Developmental Neurogenetics of Females with ASD

Award Number: R01MH100028

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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