Friday, April 19, 2024 4/19/2024

Environmental hygiene strategies to decrease the burden of antibiotic-resistant organisms in Intensive Care Unit SINKs (ICU SINK)

Award Number: R01HS027621
ORGANIZATION: AGENCY FOR HEALTH CARE RESEARCH AND QUALITY
OPDIV: AHRQ
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Group Awards By Issue Date FY or Funding FY:

View Award Abstract

PROJECT SUMMARY Infections due to antibiotic resistant organisms (ARO) are a major threat to public health worldwide and a significant cause of healthcare-associated infections (HAI). AROs are especially threatening to immunocompromised patients in intensive care units (ICUs), where a weakened immune system combined with cancer chemotherapy and antibiotic exposures results in increased risk for HAIs due to AROs. A potential source of ARO transmission is the hospital environment. AROs can survive on objects and surfaces in the ICU for prolonged time intervals, resulting in fixed reservoirs for ongoing ARO transmission to vulnerable patients. To create and optimize infection prevention strategies, it is crucial to understand the link between the hospital environment and HAIs, and to optimize environmental hygiene intervention strategies to prevent HAIs due to AROs. To characterize the environmental areas with the greatest ARO burden in the ICU, our group cultured, identified, and created a biospecimen repository of 1,109 potential AROs from collected from ICU surfaces, patient fecal samples, and clinical bloodstream infection (BSI) isolates from patients admitted to the bone marrow transplant (BMT) ICU. Our preliminary selective microbiologic culture techniques and whole genome sequencing (WGS) data indicate that there is a genetic link between AROs isolated from sink drains and clinical BSI isolates. This raises the hypothesis that AROs in sink drains are being transferred between the ICU environment and patients (or vice-versa), and that the environment may be a reservoir for ARO transmission. Based on these preliminary data, our goal is to define the link between AROs found in the ICU environment and patients with HAIs, and to design and test interventions to reduce the burden of AROs in the ICU environment. In this project, we will utilize antimicrobial susceptibility testing and WGS to longitudinally determine the presence and transmission of AROs across the hospital environment, and determine the genetic link between these strains to those causing BSIs in patients in a BMT ICU. Further, we will implement and measure the impact of a bleach and hydrogen peroxide-based environmental hygiene intervention on the concentration of AROs present in ICU sink drains. Completion of these specific aims will allow us to extensively characterize the transmission dynamics of AROs across environmental surfaces and patients, and to evaluate an environmental hygiene intervention that focuses on sink surfaces and drains.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $481,910 )
2023	2023	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Research on Healthcare Costs, Quality and Outcomes	000	4	6/21/2023	NON-COMPETING CONTINUATION	$481,910
														Subtotal = $481,910

Issue Date FY: 2022 ( Subtotal = $480,674 )
2022	2022	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Research on Healthcare Costs, Quality and Outcomes	000	3	6/9/2022	NON-COMPETING CONTINUATION	$480,674
														Subtotal = $480,674

Issue Date FY: 2021 ( Subtotal = $486,558 )
2021	2021	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Research on Healthcare Costs, Quality and Outcomes	001	2	6/23/2021	NON-COMPETING CONTINUATION	$486,558
2021	2020	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Research on Healthcare Costs, Quality and Outcomes	000	1	6/23/2021	NEW	$0
														Subtotal = $486,558

Issue Date FY: 2020 ( Subtotal = $499,999 )
2020	2020	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Research on Healthcare Costs, Quality and Outcomes	000	1	8/13/2020	NEW	$499,999
														Subtotal = $499,999

Grand Total All Awards = $1,949,141

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Environmental hygiene strategies to decrease the burden of antibiotic-resistant organisms in Intensive Care Unit SINKs (ICU SINK)

Award Number: R01HS027621

ORGANIZATION: AGENCY FOR HEALTH CARE RESEARCH AND QUALITY

OPDIV: AHRQ

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer