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Genetic ancestry effects on molecular and complex traits in TOPMed

Award Number: R01HL175076
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/25/2025
PERIOD OF PERFORMANCE END DATE: 04/30/2029

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Genetic ancestry effects on molecular and complex traits in TOPMed - ABSTRACT: The Trans-Omics for Precision Medicine (TOPMed) project has reached a critical size threshold. Freeze 10 of the TOPMed cohort now includes n=180,852 individuals with high coverage WGS, with over 1.074 BILLION variants characterized. Beyond genomic data, TOPMed also includes n=73,294 individuals with RNA-seq gene expression data, n=92,659 individuals with metabolomic data, n=85,684 individuals with methylation data, and n=43,057 individuals with proteomic data. These ‘omics phenotypes enable rich characterization of the multiple dimensions of biology that are relevant for human disease. Importantly, 60% of individuals identify as non-White with n>51k of individuals identifying as Black/African American, n>34k identifying as Hispanic/Latino, and span multiple HLBS phenotypes. We will utilize the TOPMed project data to address two pressing questions. First, how do race, ethnicity, and genetic ancestry contribute to complex traits across the continuum of human populations in the US? Second, how do alleles at different frequencies in different genetic ancestry groups contribute to complex traits? This project will leverage data from whole genome sequencing (WGS), RNAseq expression, metabolomics, and a bevy of heart, lung, blood, and sleep disorders to make headway understanding how to keep the continuum of human populations at the forefront of precision medicine.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $804,982 )
2026	2026	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Cardiovascular Diseases Research	000	2	5/14/2026	NON-COMPETING CONTINUATION	$804,982
														Subtotal = $804,982

Issue Date FY: 2025 ( Subtotal = $804,982 )
2025	2025	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Cardiovascular Diseases Research	000	1	7/23/2025	NEW	$804,982
														Subtotal = $804,982

Grand Total All Awards = $1,609,964

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Genetic ancestry effects on molecular and complex traits in TOPMed

Award Number: R01HL175076

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/25/2025

PERIOD OF PERFORMANCE END DATE: 04/30/2029

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