Saturday, November 23, 2024 11/23/2024

Patient-Specific Coronary Hemodynamics by 3D Printing

Award Number: R01HL118019
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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ABSTRACT. Despite improvements in therapies targeted at reducing disease burden, CAD continues to afflict >16 million US adults, accounting for more than 1/3 of all deaths and responsible for ~1.2 million hospitalizations annually. Coronary revascularization remains a mainstay of treatment for CAD, with >1.2 million percutaneous interventions performed annually in the US. Prior multicenter trials have demonstrated propitious outcomes for individuals with who undergo ischemia-guided revascularization by fractional flow reserve (FFR)—an invasive “gold” standard that determines the physiologic significance of coronary stenoses. More recently we have studied the accuracy of a non-invasive CT-based alternative to FFR, termed FFRCT. While this new method is moderately accurate, it possesses several limitations such as assuming the walls of the coronaries are rigid and flow is non-pulsatile. Therefore, we have determined an alternative approach to assessing coronary hemodynamics via 3D printing, which allows physical measurements of coronary flow using realistic tissue mechanics and pulsatile flow. In this application, we will optimize the hardware, software, workflows, and analysis to build and evaluate coronary hemodynamics based on patient CT images. Extensive clinical imaging data, including 15O-H2O labeled PET imaging will be used to validate the accuracy of these models for predicting coronary hemodynamics. Finally, these 3D printed models will be used to develop clinically useful reports that can provide diagnostic determination of a patient's level of ischemia using only non-invasive CT imaging.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$321,492 )
2025	2022	WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY	575 LEXINGTON AVE FL 9	NEW YORK	NY	10022	NEW YORK	USA	Cardiovascular Diseases Research	000	9	11/7/2024	NON-COMPETING CONTINUATION	-$321,492
														Subtotal = -$321,492

Issue Date FY: 2022 ( Subtotal = $640,399 )
2022	2022	WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY	1300 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Cardiovascular Diseases Research	001	9	6/29/2022	NON-COMPETING CONTINUATION	$64,040
2022	2022	WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY	1300 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Cardiovascular Diseases Research	000	9	4/8/2022	NON-COMPETING CONTINUATION	$576,359
														Subtotal = $640,399

Issue Date FY: 2021 ( Subtotal = $674,199 )
2021	2021	WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY	1300 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Cardiovascular Diseases Research	000	8	4/7/2021	NON-COMPETING CONTINUATION	$674,199
														Subtotal = $674,199

Issue Date FY: 2020 ( Subtotal = $664,380 )
2020	2020	WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY	407 E 61ST ST RM 106 1ST FL	NEW YORK	NY	10065	NEW YORK	USA	Cardiovascular Diseases Research	001	7	4/13/2020	NON-COMPETING CONTINUATION	$664,380
2020	2019	WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY	407 E 61ST ST RM 106 1ST FL	NEW YORK	NY	10065	NEW YORK	USA	Cardiovascular Diseases Research	000	6	12/20/2019	COMPETING CONTINUATION	$0
														Subtotal = $664,380

Issue Date FY: 2019 ( Subtotal = $630,569 )
2019	2019	WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY	407 E 61ST ST RM 106 1ST FL	NEW YORK	NY	10065	NEW YORK	USA	Cardiovascular Diseases Research	001	6	5/7/2019	COMPETING CONTINUATION	$630,569
2019	2019	WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY	407 E 61ST ST RM 106 1ST FL	NEW YORK	NY	10065	NEW YORK	USA	Cardiovascular Diseases Research	004	6	8/21/2019	COMPETING CONTINUATION	$112,507
2019	2019	WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY	407 E 61ST ST RM 106 1ST FL	NEW YORK	NY	10065	NEW YORK	USA	Cardiovascular Diseases Research	002	6	6/24/2019	COMPETING CONTINUATION	$0
2019	2017	CEDARS-SINAI MEDICAL CENTER	8700 BEVERLY BLVD	LOS ANGELES	CA	90048	LOS ANGELES	USA	Cardiovascular Diseases Research	003	5	8/21/2019	NON-COMPETING CONTINUATION	-$112,507
2019	2017	CEDARS-SINAI MEDICAL CENTER	8700 BEVERLY BLVD	LOS ANGELES	CA	90048	LOS ANGELES	USA	Cardiovascular Diseases Research	000	5	5/4/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $630,569

Issue Date FY: 2018 ( Subtotal = $0 )
2018	2016	CEDARS-SINAI MEDICAL CENTER	8700 BEVERLY BLVD	LOS ANGELES	CA	90048	LOS ANGELES	USA	Cardiovascular Diseases Research	001	4	1/23/2018	EXTENSION WITH OR WITHOUT FUNDS	$203
2018	2015	CEDARS-SINAI MEDICAL CENTER	8700 BEVERLY BLVD	LOS ANGELES	CA	90048	LOS ANGELES	USA	Cardiovascular Diseases Research	000	3	1/23/2018	NON-COMPETING CONTINUATION	-$203
														Subtotal = $0

Issue Date FY: 2017 ( Subtotal = $506,139 )
2017	2017	CEDARS-SINAI MEDICAL CENTER	8700 BEVERLY BLVD	LOS ANGELES	CA	90048	LOS ANGELES	USA	Cardiovascular Diseases Research	002	5	7/7/2017	NON-COMPETING CONTINUATION	$506,139
2017	2016	CEDARS-SINAI MEDICAL CENTER	8700 BEVERLY BLVD	LOS ANGELES	CA	90048	LOS ANGELES	USA	Cardiovascular Diseases Research	004	4	7/13/2017	EXTENSION WITH OR WITHOUT FUNDS	$1,050
2017	2016	CEDARS-SINAI MEDICAL CENTER	8700 BEVERLY BLVD	LOS ANGELES	CA	90048	LOS ANGELES	USA	Cardiovascular Diseases Research	001	4	3/22/2017	EXTENSION WITH OR WITHOUT FUNDS	$3,384
2017	2015	CEDARS-SINAI MEDICAL CENTER	8700 BEVERLY BLVD	LOS ANGELES	CA	90048	LOS ANGELES	USA	Cardiovascular Diseases Research	000	3	3/22/2017	NON-COMPETING CONTINUATION	-$3,384
2017	2015	CEDARS-SINAI MEDICAL CENTER	8700 BEVERLY BLVD	LOS ANGELES	CA	90048	LOS ANGELES	USA	Cardiovascular Diseases Research	003	3	7/13/2017	NON-COMPETING CONTINUATION	-$1,050
														Subtotal = $506,139

Issue Date FY: 2016 ( Subtotal = $669,241 )
2016	2016	CORNELL UNIVERSITY, MEDICAL COLLEGE	1300 YORK AVENUE, S 217	NEW YORK-NEW YORK	NY	10021		USA	Cardiovascular Diseases Research	000	4	7/8/2016	EXTENSION WITH OR WITHOUT FUNDS	$669,241
														Subtotal = $669,241

Issue Date FY: 2015 ( Subtotal = $663,072 )
2015	2015	CORNELL UNIVERSITY, MEDICAL COLLEGE	1300 YORK AVENUE, S 217	NEW YORK-NEW YORK	NY	10021		USA	Cardiovascular Diseases Research	000	3	6/23/2015	NON-COMPETING CONTINUATION	$663,072
														Subtotal = $663,072

Issue Date FY: 2014 ( Subtotal = $654,832 )
2014	2014	CORNELL UNIVERSITY, MEDICAL COLLEGE	1300 YORK AVENUE, S 217	NEW YORK-NEW YORK	NY	10021		USA	Cardiovascular Diseases Research	000	2	7/25/2014	NON-COMPETING CONTINUATION	$654,832
														Subtotal = $654,832

Issue Date FY: 2013 ( Subtotal = $693,866 )
2013	2013	CORNELL UNIVERSITY, MEDICAL COLLEGE	1300 YORK AVENUE, S 217	NEW YORK-NEW YORK	NY	10021		USA	Cardiovascular Diseases Research	000	1	8/28/2013	NEW	$693,866
														Subtotal = $693,866

Grand Total All Awards = $5,475,205

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Patient-Specific Coronary Hemodynamics by 3D Printing

Award Number: R01HL118019

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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