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Functional Interactions of Cardiac Ion Channels

Award Number: R01HL085844
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Group Awards By Issue Date FY or Funding FY:

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Abstract Our laboratory was the first to demonstrate unequivocally that several isoforms of small conductance Ca2+- activated K+ channels (SK or KCa2 channels) underlie Ca2+-activated K+ current (IK,Ca) in cardiomyocytes. Indeed, interests in cardiac SK channels are fueled by recent studies suggesting the possible roles of SK channels in human atrial fibrillation (AF) and up-regulation of SK channels in heart failure (HF). Therefore, SK channel may represent a novel therapeutic target for cardiac arrhythmias. Even though the activation and trafficking of SK channels are Ca2+-dependent, the Ca2+ source remains undefined. In addition, the Ca2+-dependence of SK channels is inextrictably linked to calmodulin (CaM), whose mutations have been shown to be associated with human arrhythmias. Since CaM is ubiquitous, it is paramount to disentangle the web of CaM-regulated ion channels from the roles of SK channels in calmodulinopathy. Moreover, SK channel expression is upregulated in HF but the exact mechanisms remain incompletely understood. Blockade of SK channels has been shown to be both anti-arrhythmic and proarrhythmic in various models. These aforementioned challenges are the premises of the present proposal. Thus, the essence of this proposal is to deploy innovative imaging, functional analyses, and molecular modeling to address successively the regulation of cardiac Ca2+-activated K+ channels in normal and failing cardiac myocytes.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $636,470 )
2023	2023	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Cardiovascular Diseases Research	000	14	8/8/2023	NON-COMPETING CONTINUATION	$636,470
														Subtotal = $636,470

Issue Date FY: 2022 ( Subtotal = $634,481 )
2022	2022	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Cardiovascular Diseases Research	002	13	7/21/2022	COMPETING CONTINUATION	$634,481
2022	2020	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Cardiovascular Diseases Research	001	12	7/16/2022	NON-COMPETING CONTINUATION	$0
2022	2020	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Cardiovascular Diseases Research	000	12	11/13/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $634,481

Issue Date FY: 2020 ( Subtotal = $481,970 )
2020	2020	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Cardiovascular Diseases Research	000	12	11/28/2019	NON-COMPETING CONTINUATION	$457,871
2020	2020	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Cardiovascular Diseases Research	001	12	1/23/2020	NON-COMPETING CONTINUATION	$24,099
														Subtotal = $481,970

Issue Date FY: 2019 ( Subtotal = $481,970 )
2019	2019	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Cardiovascular Diseases Research	000	11	12/14/2018	NON-COMPETING CONTINUATION	$481,970
														Subtotal = $481,970

Issue Date FY: 2018 ( Subtotal = $481,970 )
2018	2018	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Cardiovascular Diseases Research	001	10	5/25/2018	NON-COMPETING CONTINUATION	$9,641
2018	2018	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Cardiovascular Diseases Research	000	10	12/6/2017	NON-COMPETING CONTINUATION	$472,329
														Subtotal = $481,970

Issue Date FY: 2017 ( Subtotal = $481,970 )
2017	2017	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Cardiovascular Diseases Research	001	9	12/9/2016	COMPETING CONTINUATION	$481,970
2017	2017	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Cardiovascular Diseases Research	003	9	4/3/2017	COMPETING CONTINUATION	$184
2017	2015	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Cardiovascular Diseases Research	000	8	12/8/2016	NON-COMPETING CONTINUATION	$0
2017	2015	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Cardiovascular Diseases Research	002	8	4/3/2017	NON-COMPETING CONTINUATION	-$184
														Subtotal = $481,970

Issue Date FY: 2015 ( Subtotal = $377,993 )
2015	2015	UNIVERSITY OF CALIFORNIA	1850 RESEARCH PARK DRIVE	DAVIS	CA	95618	YOLO	USA	Cardiovascular Diseases Research	000	8	7/23/2015	NON-COMPETING CONTINUATION	$377,993
														Subtotal = $377,993

Issue Date FY: 2014 ( Subtotal = $321,189 )
2014	2014	UNIVERSITY OF CALIFORNIA	1850 RESEARCH PARK DRIVE	DAVIS	CA	95618	YOLO	USA	Cardiovascular Diseases Research	001	7	7/10/2014	NON-COMPETING CONTINUATION	$376,075
2014	2013	UNIVERSITY OF CALIFORNIA	1850 RESEARCH PARK DRIVE	DAVIS	CA	95618	YOLO	USA	Cardiovascular Diseases Research	000	6	7/10/2014	NON-COMPETING CONTINUATION	-$54,886
														Subtotal = $321,189

Issue Date FY: 2013 ( Subtotal = $443,179 )
2013	2013	UNIVERSITY OF CALIFORNIA	1441 RESEARCH PARK DRIVE	DAVIS	CA	95616	YOLO	USA	Cardiovascular Diseases Research	001	6	7/16/2013	NON-COMPETING CONTINUATION	$427,292
2013	2013	UNIVERSITY OF CALIFORNIA	1441 RESEARCH PARK DRIVE	DAVIS	CA	95616	YOLO	USA	Cardiovascular Diseases Research	000	5	5/3/2013	SUPPLEMENT FOR EXPANSION	$15,887
														Subtotal = $443,179

Issue Date FY: 2012 ( Subtotal = $384,896 )
2012	2012	UNIVERSITY OF CALIFORNIA	1441 RESEARCH PARK DRIVE	DAVIS	CA	95616	YOLO	USA	Cardiovascular Diseases Research	000	5	8/11/2012	COMPETING CONTINUATION	$384,896
														Subtotal = $384,896

Issue Date FY: 2010 ( Subtotal = $380,000 )
2010	2010	UNIVERSITY OF CALIFORNIA	1441 RESEARCH PARK DRIVE	DAVIS	CA	95616	YOLO	USA	Cardiovascular Diseases Research	000	4	2/5/2010	NON-COMPETING CONTINUATION	$380,000
														Subtotal = $380,000

Issue Date FY: 2009 ( Subtotal = $380,000 )
2009	2009	UNIVERSITY OF CALIFORNIA	1441 RESEARCH PARK DRIVE	DAVIS	CA	95616	YOLO	USA	Cardiovascular Diseases Research	000	3	2/10/2009	NON-COMPETING CONTINUATION	$380,000
														Subtotal = $380,000

Issue Date FY: 2008 ( Subtotal = $380,000 )
2008	2008	UNIVERSITY OF CALIFORNIA	1441 RESEARCH PARK DRIVE	DAVIS	CA	95616	YOLO	USA	Cardiovascular Diseases Research	000	2	2/9/2008	NON-COMPETING CONTINUATION	$380,000
														Subtotal = $380,000

Issue Date FY: 2007 ( Subtotal = $380,000 )
2007	2007	UNIVERSITY OF CALIFORNIA	1441 RESEARCH PARK DRIVE	DAVIS	CA	95616	YOLO	USA	Cardiovascular Diseases Research	000	1	4/16/2007	NEW	$380,000
														Subtotal = $380,000

Grand Total All Awards = $6,246,088

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Functional Interactions of Cardiac Ion Channels

Award Number: R01HL085844

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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