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Kisspeptin and Neurokinin B: Physiology in Monkey to Pathophysiology in Human

Award Number: R01HD043341
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Group Awards By Issue Date FY or Funding FY:

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¿ DESCRIPTION (provided by applicant): Kisspeptin and neurokinin B are both critical gatekeepers for reproductive maturation but there is still much to learn about how these neuropeptides stimulate GnRH secretion. This grant will anchor a collaboration between two investigators uniquely positioned to study the physiology of these peptides in non-human primates and humans in vivo. In the male monkey, the contributions of kisspeptin and NKB to GnRH secretion will be explored across puberty using novel assays and receptor agonists and antagonists. In the adult human male, exogenous kisspeptin administration to patients with idiopathic hypogonadotropic hypogonadism (IHH) will be assessed as a predictive tool for spontaneous recovery of GnRH pulsatile secretion. In the adolescent human male, exogenous kisspeptin will be explored as a diagnostic tool to distinguish between constitutional delay of puberty (CDP) and IHH. By focusing on the pubertal transition, and incorporating normal and pathophysiologic states, this grant will develop insights into reproductive maturation and develop diagnostic tools for pubertal disorders.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2022 ( Subtotal = -$14,088 )
2022	2019	THE GENERAL HOSPITAL CORPORATION	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Child Health and Human Development Extramural Research	000	17	8/29/2022	NON-COMPETING CONTINUATION	-$14,088
														Subtotal = -$14,088

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2019	MASSACHUSETTS GENERAL HOSPITAL, THE	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Child Health and Human Development Extramural Research	000	17	7/30/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2019 ( Subtotal = $361,270 )
2019	2019	MASSACHUSETTS GENERAL HOSPITAL, THE	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Child Health and Human Development Extramural Research	000	17	2/12/2019	NON-COMPETING CONTINUATION	$361,270
														Subtotal = $361,270

Issue Date FY: 2018 ( Subtotal = $362,897 )
2018	2018	MASSACHUSETTS GENERAL HOSPITAL, THE	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Child Health and Human Development Extramural Research	000	16	2/1/2018	NON-COMPETING CONTINUATION	$326,607
2018	2018	MASSACHUSETTS GENERAL HOSPITAL, THE	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Child Health and Human Development Extramural Research	001	16	4/19/2018	NON-COMPETING CONTINUATION	$36,290
2018	2017	MASSACHUSETTS GENERAL HOSPITAL, THE	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Child Health and Human Development Extramural Research	002	15	9/26/2018	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $362,897

Issue Date FY: 2017 ( Subtotal = $466,407 )
2017	2017	MASSACHUSETTS GENERAL HOSPITAL, THE	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Child Health and Human Development Extramural Research	001	15	6/13/2017	NON-COMPETING CONTINUATION	$38,279
2017	2017	MASSACHUSETTS GENERAL HOSPITAL, THE	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Child Health and Human Development Extramural Research	002	15	8/23/2017	SUPPLEMENT FOR EXPANSION	$83,627
2017	2017	MASSACHUSETTS GENERAL HOSPITAL, THE	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Child Health and Human Development Extramural Research	000	15	1/11/2017	NON-COMPETING CONTINUATION	$344,501
														Subtotal = $466,407

Issue Date FY: 2016 ( Subtotal = $454,978 )
2016	2016	MASSACHUSETTS GENERAL HOSPITAL	32 FRUIT STREET	BOSTON	MA	02114	SUFFOLK	USA	Child Health and Human Development Extramural Research	000	14	1/29/2016	NON-COMPETING CONTINUATION	$454,978
														Subtotal = $454,978

Issue Date FY: 2015 ( Subtotal = $479,607 )
2015	2015	MASSACHUSETTS GENERAL HOSPITAL	32 FRUIT STREET	BOSTON	MA	02114	SUFFOLK	USA	Child Health and Human Development Extramural Research	000	13	2/25/2015	COMPETING CONTINUATION	$479,607
2015	2013	MASSACHUSETTS GENERAL HOSPITAL	32 FRUIT STREET	BOSTON	MA	02114	SUFFOLK	USA	Child Health and Human Development Extramural Research	001	12	2/25/2015	NON-COMPETING CONTINUATION	$0
														Subtotal = $479,607

Issue Date FY: 2013 ( Subtotal = $331,256 )
2013	2013	MASSACHUSETTS GENERAL HOSPITAL	32 FRUIT STREET	BOSTON	MA	02114	SUFFOLK	USA	Child Health and Human Development Extramural Research	000	12	7/25/2013	NON-COMPETING CONTINUATION	$331,256
														Subtotal = $331,256

Issue Date FY: 2012 ( Subtotal = $349,058 )
2012	2012	MASSACHUSETTS GENERAL HOSPITAL	32 FRUIT STREET	BOSTON	MA	02114	SUFFOLK	USA	Child Health and Human Development Extramural Research	000	11	8/6/2012	NON-COMPETING CONTINUATION	$349,058
														Subtotal = $349,058

Issue Date FY: 2011 ( Subtotal = $349,058 )
2011	2011	MASSACHUSETTS GENERAL HOSPITAL	32 FRUIT STREET	BOSTON	MA	02114	SUFFOLK	USA	Population Research	000	10	8/10/2011	NON-COMPETING CONTINUATION	$349,058
														Subtotal = $349,058

Issue Date FY: 2010 ( Subtotal = $363,602 )
2010	2010	MASSACHUSETTS GENERAL HOSPITAL	32 FRUIT STREET	BOSTON	MA	02114	SUFFOLK	USA	Population Research	000	9	8/25/2010	NON-COMPETING CONTINUATION	$363,602
														Subtotal = $363,602

Issue Date FY: 2009 ( Subtotal = $521,262 )
2009	2009	MASSACHUSETTS GENERAL HOSPITAL	32 FRUIT STREET	BOSTON	MA	02114	SUFFOLK	USA	Child Health and Human Development Extramural Research	000	7	4/21/2009	NON-COMPETING CONTINUATION	$154,333
2009	2009	MASSACHUSETTS GENERAL HOSPITAL	32 FRUIT STREET	BOSTON	MA	02114	SUFFOLK	USA	Population Research	001	8	9/17/2009	COMPETING CONTINUATION	$366,929
														Subtotal = $521,262

Issue Date FY: 2008 ( Subtotal = $361,698 )
2008	2008	MASSACHUSETTS GENERAL HOSPITAL	32 FRUIT STREET	BOSTON	MA	02114	SUFFOLK	USA	Child Health and Human Development Extramural Research	000	6	4/1/2008	NON-COMPETING CONTINUATION	$361,698
														Subtotal = $361,698

Issue Date FY: 2007 ( Subtotal = $369,080 )
2007	2007	MASSACHUSETTS GENERAL HOSPITAL	32 FRUIT STREET	BOSTON	MA	02114	SUFFOLK	USA	Child Health and Human Development Extramural Research	000	5	4/16/2007	NON-COMPETING CONTINUATION	$369,080
														Subtotal = $369,080

Issue Date FY: 2006 ( Subtotal = $380,103 )
2006	2006	MASSACHUSETTS GENERAL HOSPITAL	32 FRUIT STREET	BOSTON	MA	02114	SUFFOLK	USA	Child Health and Human Development Extramural Research	000	4	3/31/2006	NON-COMPETING CONTINUATION	$380,103
														Subtotal = $380,103

Issue Date FY: 2005 ( Subtotal = $389,250 )
2005	2005	MASSACHUSETTS GENERAL HOSPITAL	32 FRUIT STREET	BOSTON	MA	02114	SUFFOLK	USA	Child Health and Human Development Extramural Research	000	3	4/15/2005	NON-COMPETING CONTINUATION	$389,250
														Subtotal = $389,250

Issue Date FY: 2004 ( Subtotal = $389,250 )
2004	2004	MASSACHUSETTS GENERAL HOSPITAL	32 FRUIT STREET	BOSTON	MA	02114	SUFFOLK	USA	Child Health and Human Development Extramural Research	000	2	2/24/2004	NON-COMPETING CONTINUATION	$389,250
														Subtotal = $389,250

Issue Date FY: 2003 ( Subtotal = $389,250 )
2003	2003	MASSACHUSETTS GENERAL HOSPITAL	32 FRUIT STREET	BOSTON	MA	02114	SUFFOLK	USA	Population Research	000	1		NEW	$389,250
														Subtotal = $389,250

Grand Total All Awards = $6,303,938

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Kisspeptin and Neurokinin B: Physiology in Monkey to Pathophysiology in Human

Award Number: R01HD043341

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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