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Visual Target Selection for Saccadic Eye Movements

Award Number: R01EY013692
ORGANIZATION: NATIONAL EYE INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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PROJECT SUMMARY A major open - and very important - question in cognitive neuroscience is: how and where in the brain are decisions made? Recent electrophysiological evidence from a cerebral cortical area thought to play a key role in perceptual decision-making (LIP) suggests that the activity of neurons in area LIP do not reflect a gradual accumulation of evidence toward a decision. Furthermore, reversible inactivation of area LIP produces no change in decision-making performance, calling into question its causal role in visual perceptual decision- making. These unexpected results open the possibility that other sensorimotor areas play a critical role in the neuronal processing leading to perceptual decisions. Our goal is to expand on these recent findings and on our accomplishments made during previous award cycles to test the hypothesis that the basal ganglia (BG) and the superior colliculus (SC) play key roles in visual perceptual decision-making. We have two specific aims: 1) Determine the role of the superior colliculus (SC) in perceptual decision-making and, 2) determine the role of the inhibition from one output nucleus of the basal ganglia, the substantia nigra pars reticulata (nigra), to the SC in perceptual decision-making. We propose to use state of the art multiple neuron recording technologies to measure population activity in the SC and in the nigra while subjects perform visual perceptual decision tasks. We will employ analytical methods to model the behavioral data and make predictions about behavior using the population neuronal data. We will also employ cutting edge molecular genetic methods to manipulate neuronal activity to determine the causal role of these brain areas in perceptual decision-making.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2021	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Vision Research	003	18	4/3/2023	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
2023	2021	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Vision Research	002	18	10/24/2022	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$347,787
2023	2021	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Vision Research	001	17	10/24/2022	NON-COMPETING CONTINUATION	-$1
2023	2020	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Vision Research	000	16	10/24/2022	NON-COMPETING CONTINUATION	-$347,786
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $1,726 )
2022	2021	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Vision Research	001	18	4/29/2022	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$568,377
2022	2021	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Vision Research	000	17	4/29/2022	NON-COMPETING CONTINUATION	-$568,376
2022	2021	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Vision Research	002	18	5/16/2022	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
2022	2019	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Vision Research	004	15	7/11/2022	COMPETING CONTINUATION	$1,725
2022	2018	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Vision Research	003	14	7/11/2022	SUPPLEMENT FOR EXPANSION	-$1,725
2022	2018	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Vision Research	005	14	9/8/2022	SUPPLEMENT FOR EXPANSION	$1,725
														Subtotal = $1,726

Issue Date FY: 2021 ( Subtotal = $568,377 )
2021	2021	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Vision Research	000	17	3/15/2021	NON-COMPETING CONTINUATION	$568,377
														Subtotal = $568,377

Issue Date FY: 2020 ( Subtotal = $589,972 )
2020	2020	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Vision Research	002	16	6/12/2020	NON-COMPETING CONTINUATION	$589,972
2020	2019	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Vision Research	001	15	3/5/2020	COMPETING CONTINUATION	$169,201
2020	2018	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Vision Research	000	14	3/5/2020	SUPPLEMENT FOR EXPANSION	-$169,201
														Subtotal = $589,972

Issue Date FY: 2019 ( Subtotal = $596,890 )
2019	2019	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Vision Research	001	15	3/28/2019	COMPETING CONTINUATION	$596,890
2019	2018	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Vision Research	000	14	3/25/2019	NON-COMPETING CONTINUATION	$0
2019	2018	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Vision Research	002	14	3/29/2019	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $596,890

Issue Date FY: 2018 ( Subtotal = $696,397 )
2018	2018	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Vision Research	002	14	9/21/2018	SUPPLEMENT FOR EXPANSION	$231,412
2018	2018	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Vision Research	000	14	11/17/2017	NON-COMPETING CONTINUATION	$418,487
2018	2018	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Vision Research	001	14	5/3/2018	NON-COMPETING CONTINUATION	$46,498
														Subtotal = $696,397

Issue Date FY: 2017 ( Subtotal = $476,381 )
2017	2017	UNIVERSITY OF CALIFORNIA, LOS ANGELES	11000 KINROSS AVE STE 102	LOS ANGELES	CA	90095	LOS ANGELES	USA	Vision Research	000	13	11/17/2016	NON-COMPETING CONTINUATION	$428,743
2017	2017	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Vision Research	001	13	7/10/2017	NON-COMPETING CONTINUATION	$47,638
														Subtotal = $476,381

Issue Date FY: 2016 ( Subtotal = $481,606 )
2016	2016	UNIVERSITY OF CALIFORNIA-LOS ANGELES, BOARD OF REGENTS	11000 KINROSS AVENUE	LOS ANGELES	CA	90095	LOS ANGELES	USA	Vision Research	000	12	12/3/2015	NON-COMPETING CONTINUATION	$433,445
2016	2016	UNIVERSITY OF CALIFORNIA-LOS ANGELES, BOARD OF REGENTS	11000 KINROSS AVENUE	LOS ANGELES	CA	90095	LOS ANGELES	USA	Vision Research	001	12	3/2/2016	NON-COMPETING CONTINUATION	$48,161
														Subtotal = $481,606

Issue Date FY: 2015 ( Subtotal = $531,221 )
2015	2015	UNIVERSITY OF CALIFORNIA-LOS ANGELES, BOARD OF REGENTS	11000 KINROSS AVENUE	LOS ANGELES	CA	90095	LOS ANGELES	USA	Vision Research	000	11	12/19/2014	COMPETING CONTINUATION	$531,221
														Subtotal = $531,221

Issue Date FY: 2013 ( Subtotal = $103,669 )
2013	2013	UNIVERSITY OF CALIFORNIA-LOS ANGELES, BOARD OF REGENTS	11000 KINROSS AVENUE	LOS ANGELES	CA	90095	LOS ANGELES	USA	Vision Research	000	10	9/6/2013	SUPPLEMENT FOR EXPANSION	$103,669
														Subtotal = $103,669

Issue Date FY: 2012 ( Subtotal = $356,662 )
2012	2012	UNIVERSITY OF CALIFORNIA-LOS ANGELES, BOARD OF REGENTS	11000 KINROSS AVENUE	LOS ANGELES	CA	90095	LOS ANGELES	USA	Vision Research	003	10	9/14/2012	NON-COMPETING CONTINUATION	$15,434
2012	2012	UNIVERSITY OF CALIFORNIA-LOS ANGELES, BOARD OF REGENTS	11000 KINROSS AVENUE	LOS ANGELES	CA	90095	LOS ANGELES	USA	Vision Research	002	10	8/30/2012	NON-COMPETING CONTINUATION	$341,228
2012	2011	UNIVERSITY OF WISCONSIN SYSTEM/BOARD OF REGENTS	21 N PARK ST	MADISON	WI	53715	DANE	USA	Vision Research	000	8	8/27/2012	NON-COMPETING CONTINUATION	-$148,500
2012	2011	UNIVERSITY OF CALIFORNIA-LOS ANGELES, BOARD OF REGENTS	11000 KINROSS AVENUE	LOS ANGELES	CA	90095	LOS ANGELES	USA	Vision Research	001	9	8/30/2012	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$148,500
														Subtotal = $356,662

Issue Date FY: 2011 ( Subtotal = $341,462 )
2011	2011	UNIVERSITY OF WISCONSIN SYSTEM/BOARD OF REGENTS	21 N PARK ST	MADISON	WI	53715	DANE	USA	Vision Research	000	8	5/19/2011	NON-COMPETING CONTINUATION	$341,462
														Subtotal = $341,462

Issue Date FY: 2010 ( Subtotal = $355,927 )
2010	2010	UNIVERSITY OF WISCONSIN SYSTEM/BOARD OF REGENTS	21 N PARK ST	MADISON	WI	53715	DANE	USA	Vision Research	000	7	6/3/2010	NON-COMPETING CONTINUATION	$355,927
														Subtotal = $355,927

Issue Date FY: 2009 ( Subtotal = $359,754 )
2009	2009	UNIVERSITY OF WISCONSIN SYSTEM/BOARD OF REGENTS	21 N PARK ST	MADISON	WI	53715	DANE	USA	Vision Research	001	6	6/12/2009	NON-COMPETING CONTINUATION	$359,754
2009	2008	UNIVERSITY OF WISCONSIN SYSTEM/BOARD OF REGENTS	21 NORTH PARK STREET	MADISON	WI	53715	DANE	USA	Vision Research	000	5	2/12/2009	COMPETING CONTINUATION	$0
														Subtotal = $359,754

Issue Date FY: 2008 ( Subtotal = $351,755 )
2008	2008	UNIVERSITY OF WISCONSIN SYSTEM/BOARD OF REGENTS	21 NORTH PARK STREET	MADISON	WI	53715	DANE	USA	Vision Research	000	5	5/19/2008	COMPETING CONTINUATION	$351,755
														Subtotal = $351,755

Grand Total All Awards = $7,036,961

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Visual Target Selection for Saccadic Eye Movements

Award Number: R01EY013692

ORGANIZATION: NATIONAL EYE INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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