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Administrative Supplement: Model-guided design of next-generation bacterial therapeutics to treat cardiovascular disease

Award Number: R01EB030340
ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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PROJECT SUMMARY/ABSTRACT It is becoming increasingly evident that the composition and metabolites produced by the human gut microbiome influence the progression of cardiovascular diseases. While we are continuing to discover important associations between the gut microbiome and human physiology and diseases, we lack the tools and methodology to precisely manipulate gut microbiota to benefit human health. We propose to develop computational models and optimization frameworks to predict community dynamics and functions and design interventions to shift the gut microbiome to desired states. We will design novel bacterial therapeutics that operate autonomously in the mammalian gastrointestinal tract to steer the microbiome towards healthy states. These next-generation bacterial therapeutics will sense important gut microbiome metabolites, process information, and deliver species- specific antimicrobial proteins to reshape the dynamics and functions of this ecosystem. The performance of these bacterial therapeutics will be characterized in vitro using synthetic human gut microbiome communities and in gnotobiotic mouse models of cardiovascular disease. Model-guided microbiome engineering has the potential to transform human medicine and is becoming increasingly important as scientists continue to discover connections between the microbiome and human health and disease.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $816,475 )
2023	2023	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	4	6/21/2023	NON-COMPETING CONTINUATION	$641,475
2023	2023	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	4	6/22/2023	SUPPLEMENT FOR EXPANSION	$175,000
														Subtotal = $816,475

Issue Date FY: 2022 ( Subtotal = $661,600 )
2022	2022	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	3	5/18/2022	NON-COMPETING CONTINUATION	$661,600
														Subtotal = $661,600

Issue Date FY: 2021 ( Subtotal = $667,219 )
2021	2021	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	2	7/19/2021	NON-COMPETING CONTINUATION	$667,219
														Subtotal = $667,219

Issue Date FY: 2020 ( Subtotal = $697,498 )
2020	2020	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	8/28/2020	NEW	$697,498
														Subtotal = $697,498

Grand Total All Awards = $2,842,792

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Administrative Supplement: Model-guided design of next-generation bacterial therapeutics to treat cardiovascular disease

Award Number: R01EB030340

ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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