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Behavioral outcomes and neurobiological mechanisms of sustained auditory selective attention

Award Number: R01DC017734
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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PROJECT SUMMARY/ABSTRACT Human communication and other listening behaviors often take place in acoustically complex, or noisy environments like schools, restaurants, and workplaces. Much of daily life requires us to select behaviorally- relevant auditory dimensions, and potentially suppress irrelevant dimensions, so that the information conveyed can be remembered and responded to appropriately. Unfortunately, this vital everyday ability is affected by many neurological conditions resulting in marked decreases in quality of life. Despite the importance of auditory selective attention, its cognitive and neural mechanisms are poorly understood. For example, although auditory selective attention is widely presumed to involve both a selective enhancement of behaviorally relevant auditory dimensions and suppression of dimensions outside this attentional focus, evidence for suppression is scant. The long-term goal of the proposed research is to arrive at a mechanistic understanding of auditory selective attention. The present project pursues the central hypothesis that human auditory selective attention is a result of processes related to both enhancement (of task-relevant sounds) and suppression (of task-irrelevant sounds). Preliminary studies establish a nonspeech experimental paradigm for engaging - and improving –auditory selective attention directed to specific frequency bands, and for non-invasively mapping it across auditory cortex using multimodal MRI. A parallel preliminary study establishes that attention training drives improvements in behavioral and electrophysiological measures of auditory selective attention. Aim 1 will determine the fine- grained `listening window' through which auditory selective attention prioritizes and selects behaviorally relevant auditory dimensions, and potentially suppresses irrelevant dimensions. These studies also will determine the extent to which tasks and expectations created from input regularities shape the listening window. Aim 2 will assess changes in the spectrotemporal shape of the auditory attentional filter as listeners learn to more efficiently deploy auditory selective attention to specific dimensions. Aim 3 will identify the neurobiological underpinnings of auditory selective attention and their changes across improvements in selective attention. In all, the proposed research will weave together classic psychophysical approaches, behavioral training as a means to introduce targeted demands on selective attention, and newly-developed human neuroimaging tools to examine human auditory selective attention along the primary axis of auditory representation – frequency. This will build a bridge from perceptuo-cognitive assays of human auditory selective attention to mechanistic electrophysiological and cellular/molecular studies thus far only undertaken with invasive nonhuman animal work, thereby compounding understanding and building a natural path toward future evidence-based approaches to the remediation of auditory attention impairments.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $467,470 )
2024	2024	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR	AUSTIN	TX	78712	TRAVIS	USA	Research Related to Deafness and Communication Disorders	003	5	4/24/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$500,377
2024	2024	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR	AUSTIN	TX	78712	TRAVIS	USA	Research Related to Deafness and Communication Disorders	008	5	7/1/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$1,400,493
2024	2023	CARNEGIE MELLON UNIVERSITY	5000 FORBES AVE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Research Related to Deafness and Communication Disorders	007	4	7/1/2024	SUPPLEMENT FOR EXPANSION	-$37,517
2024	2023	CARNEGIE MELLON UNIVERSITY	5000 FORBES AVE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Research Related to Deafness and Communication Disorders	001	4	4/15/2024	SUPPLEMENT FOR EXPANSION	-$31,090
2024	2023	CARNEGIE MELLON UNIVERSITY	5000 FORBES AVE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Research Related to Deafness and Communication Disorders	002	4	4/24/2024	NON-COMPETING CONTINUATION	$0
2024	2023	CARNEGIE MELLON UNIVERSITY	5000 FORBES AVE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Research Related to Deafness and Communication Disorders	006	4	7/1/2024	NON-COMPETING CONTINUATION	-$526,047
2024	2022	CARNEGIE MELLON UNIVERSITY	5000 FORBES AVE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Research Related to Deafness and Communication Disorders	005	3	7/1/2024	NON-COMPETING CONTINUATION	-$502,628
2024	2021	CARNEGIE MELLON UNIVERSITY	5000 FORBES AVE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Research Related to Deafness and Communication Disorders	000	2	4/15/2024	NON-COMPETING CONTINUATION	-$1,817
2024	2021	CARNEGIE MELLON UNIVERSITY	5000 FORBES AVE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Research Related to Deafness and Communication Disorders	004	2	7/1/2024	NON-COMPETING CONTINUATION	-$334,301
														Subtotal = $467,470

Issue Date FY: 2023 ( Subtotal = $594,654 )
2023	2023	CARNEGIE MELLON UNIVERSITY	5000 FORBES AVE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Research Related to Deafness and Communication Disorders	000	4	3/14/2023	NON-COMPETING CONTINUATION	$473,444
2023	2023	CARNEGIE MELLON UNIVERSITY	5000 FORBES AVE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Research Related to Deafness and Communication Disorders	002	4	3/15/2023	SUPPLEMENT FOR EXPANSION	$68,607
2023	2023	CARNEGIE MELLON UNIVERSITY	5000 FORBES AVE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Research Related to Deafness and Communication Disorders	001	4	3/15/2023	NON-COMPETING CONTINUATION	$52,603
														Subtotal = $594,654

Issue Date FY: 2022 ( Subtotal = $502,628 )
2022	2022	CARNEGIE MELLON UNIVERSITY	5000 FORBES AVE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Research Related to Deafness and Communication Disorders	000	3	12/18/2021	NON-COMPETING CONTINUATION	$431,784
2022	2022	CARNEGIE MELLON UNIVERSITY	5000 FORBES AVE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Research Related to Deafness and Communication Disorders	001	3	4/21/2022	NON-COMPETING CONTINUATION	$47,975
2022	2022	CARNEGIE MELLON UNIVERSITY	5000 FORBES AVE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Research Related to Deafness and Communication Disorders	002	3	8/24/2022	NON-COMPETING CONTINUATION	$22,869
														Subtotal = $502,628

Issue Date FY: 2021 ( Subtotal = $476,005 )
2021	2021	CARNEGIE MELLON UNIVERSITY	5000 FORBES AVE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Research Related to Deafness and Communication Disorders	002	2	2/9/2021	NON-COMPETING CONTINUATION	$0
2021	2021	CARNEGIE MELLON UNIVERSITY	5000 FORBES AVE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Research Related to Deafness and Communication Disorders	001	2	1/8/2021	NON-COMPETING CONTINUATION	$47,599
2021	2021	CARNEGIE MELLON UNIVERSITY	5000 FORBES AVE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Research Related to Deafness and Communication Disorders	003	2	2/24/2021	NON-COMPETING CONTINUATION	$0
2021	2021	CARNEGIE MELLON UNIVERSITY	5000 FORBES AVE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Research Related to Deafness and Communication Disorders	000	2	12/16/2020	NON-COMPETING CONTINUATION	$428,406
														Subtotal = $476,005

Issue Date FY: 2020 ( Subtotal = $520,466 )
2020	2020	CARNEGIE MELLON UNIVERSITY	5000 FORBES AVE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Research Related to Deafness and Communication Disorders	005	1	6/25/2020	SUPPLEMENT FOR EXPANSION	$23,373
2020	2020	CARNEGIE MELLON UNIVERSITY	5000 FORBES AVE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Research Related to Deafness and Communication Disorders	000	1	11/29/2019	NEW	$476,610
2020	2020	CARNEGIE MELLON UNIVERSITY	5000 FORBES AVE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Research Related to Deafness and Communication Disorders	002	1	12/31/2019	NEW	$0
2020	2020	CARNEGIE MELLON UNIVERSITY	5000 FORBES AVE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Research Related to Deafness and Communication Disorders	004	1	6/11/2020	NEW	$0
2020	2020	CARNEGIE MELLON UNIVERSITY	5000 FORBES AVE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Research Related to Deafness and Communication Disorders	003	1	2/3/2020	NEW	$20,483
2020	2020	CARNEGIE MELLON UNIVERSITY	5000 FORBES AVE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Research Related to Deafness and Communication Disorders	001	1	12/11/2019	NEW	$0
														Subtotal = $520,466

Grand Total All Awards = $2,561,223

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Behavioral outcomes and neurobiological mechanisms of sustained auditory selective attention

Award Number: R01DC017734

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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