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The Association of Perinatal HIV Infection and Hearing Loss in Children of Cape Town, South Africa

Award Number: R01DC015984
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Abstract There is strong evidence of human immunodeficiency virus infected (HIV+) children being more at risk for hearing loss. Identification of permanent hearing loss is important because hearing loss can impact speech and language development in children. The primary goal is to collect hearing sensitivity data from South African children who were perinatally infected with HIV (PHIV+). Children will be recruited from two ongoing studies in Cape Town, South Africa: the Children with HIV Early Antiretroviral Therapy (CHER) trial and the P1104s study of the International Maternal Pediatric Adolescent AIDS Clinical Trial (IMPAACT). Hearing data will be obtained in PHIV+, HIV-exposed but uninfected (PHEU), and HIV-unexposed and uninfected (HU) children using a hearing examination protocol. The hearing protocol includes: 1) otoscopy, to evaluate the ear canal and tympanic membrane; 2) tympanometry, to evaluate middle-ear function; 3) pure-tone air- and bone-conduction audiometry, speech audiometry, dichotic digits testing (together with measures of neurocognitive function), to evaluate the entire auditory system; 4) distortion product otoacoustic emissions (DPOAEs), to evaluate cochlear function within the inner ear; and 5) auditory brainstem responses (ABRs), to evaluate auditory neural function to the level of the brainstem. Advanced multimodal neuroimaging techniques, including structural magnetic resonance imaging (MRI) for morphometry, task based and resting state functional MRI (FMRI) to assess auditory cortex function and network connectivity, and diffusion tensor imaging, will be used to evaluate the effects of HIV on the different components of the central auditory system in a comprehensive way. Speech audiometry measures will also be used to determine the impact of HIV on communication. Using DPOAEs, ABRs, and imaging in one protocol will allow for an examination of how specific auditory stimuli are processed from within the cochlea, along the auditory neural pathway to the brainstem, and finally to targeted components of the auditory cortex. These measures will contribute to a better understanding as to which portions of the auditory system are more vulnerable to HIV. There are two advantages of this proposal. First there is an existing collaboration with researchers in Cape Town and there is a new collaboration with neuroimaging experts in Cape Town; the continued support from CHER and P1104s researchers will allow for access to extensive demographic data and HIV disease and treatment data since childhood. Second, the extensive hearing protocol paired with an extensive neuroimaging protocol will provide the first of its kind data in HIV-infected children. These data will impact both the HIV and hearing literatures.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$1 )
2025	2021	SAN DIEGO STATE UNIVERSITY FOUNDATION	5250 CAMPANILE DR	SAN DIEGO	CA	92182	SAN DIEGO	USA	Research Related to Deafness and Communication Disorders	000	5	12/5/2024	NON-COMPETING CONTINUATION	-$1
														Subtotal = -$1

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2021	SAN DIEGO STATE UNIVERSITY FOUNDATION	5250 CAMPANILE DR MC1947	SAN DIEGO	CA	92182	SAN DIEGO	USA	Research Related to Deafness and Communication Disorders	000	5	7/17/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $394,278 )
2021	2021	SAN DIEGO STATE UNIVERSITY FOUNDATION	5250 CAMPANILE DR MC1947	SAN DIEGO	CA	92182	SAN DIEGO	USA	Research Related to Deafness and Communication Disorders	000	5	7/21/2021	NON-COMPETING CONTINUATION	$394,278
														Subtotal = $394,278

Issue Date FY: 2020 ( Subtotal = $350,882 )
2020	2020	SAN DIEGO STATE UNIVERSITY FOUNDATION	5250 CAMPANILE DR MC1947	SAN DIEGO	CA	92182	SAN DIEGO	USA	Research Related to Deafness and Communication Disorders	000	4	7/18/2020	NON-COMPETING CONTINUATION	$350,882
														Subtotal = $350,882

Issue Date FY: 2019 ( Subtotal = $319,235 )
2019	2019	SAN DIEGO STATE UNIVERSITY FOUNDATION	5250 CAMPANILE DR MC1947	SAN DIEGO	CA	92182	SAN DIEGO	USA	Research Related to Deafness and Communication Disorders	000	3	7/15/2019	NON-COMPETING CONTINUATION	$319,235
														Subtotal = $319,235

Issue Date FY: 2018 ( Subtotal = $328,466 )
2018	2018	SAN DIEGO STATE UNIVERSITY FOUNDATION	5250 CAMPANILE DR MC1947	SAN DIEGO	CA	92182	SAN DIEGO	USA	Research Related to Deafness and Communication Disorders	000	2	7/25/2018	NON-COMPETING CONTINUATION	$328,466
														Subtotal = $328,466

Issue Date FY: 2017 ( Subtotal = $474,090 )
2017	2017	SAN DIEGO STATE UNIVERSITY FOUNDATION	5250 CAMPANILE DR MC1947	SAN DIEGO	CA	92182	SAN DIEGO	USA	Research Related to Deafness and Communication Disorders	000	1	8/10/2017	NEW	$474,090
														Subtotal = $474,090

Grand Total All Awards = $1,866,950

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The Association of Perinatal HIV Infection and Hearing Loss in Children of Cape Town, South Africa

Award Number: R01DC015984

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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