Tuesday, April 23, 2024 4/23/2024

Synaptic organization and plasticity of the input from the amygdala to the gustatory cortex

Award Number: R01DC013770
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Summary The perception of taste is a complex process that includes the chemosensory detection of a stimulus as well as information regarding its hedonic value, whether a stimulus is pleasant or unpleasant. The gustatory cortex is thought to be a central component of the taste system, and is hypothesized to integrate both of chemosensory and affective dimensions of taste stimuli. However, to date, the neuronal and circuit mechanisms involved in this process remain unclear. In this proposal, we will fill a gap in the current understanding of circuit underpinning for taste by investigating the synaptic mechanisms underlying the integration of thalamocortical and amygdalocortical inputs to the primary gustatory cortex. The thalamocortical projection from the taste thalamus provides the gateway for chemosensory information to the gustatory cortex, while the basolateral nucleus of the amygdala has been identified as a major contributor of hedonic information regarding taste stimuli. Taking advantage of cutting-edge experimental approaches for circuit and synaptic analysis, and of a well-established learning paradigm, conditioned taste aversion, that preserves the chemosensory identity, but alters a stimulus affective dimension, we will determine how sensory and hedonic components of taste are integrated in the gustatory cortical circuit. The approach we propose will begin to bridge the gap between the extensive behavioral/ pharmacological and cellular/molecular work that has significantly advanced the field, but without information about underlying synaptic and circuit mechanisms remains difficult to reconcile in an overarching framework. In addition, our study has important implication for public health. Many neurological and psychiatric disorders are associated with altered sensory perception, or by anhedonia. Taste perception in human and rodents is characterized by sensory and affective dimensions, therefore it provides a unique model for understanding common mechanism of sensory processing, as well as for investigating the circuit underpinning for the integration of sensory stimuli with their hedonic value. Therefore, results from our current study have the potential of identifying novel targets for the development of therapeutic intervention.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $337,563 )
2023	2023	THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK	W5510 FRANKS MELVILLE MEMORIAL LIBRARY	STONY BROOK	NY	11794	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	000	10	2/18/2023	NON-COMPETING CONTINUATION	$337,563
														Subtotal = $337,563

Issue Date FY: 2022 ( Subtotal = $337,563 )
2022	2022	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	WEST 5510 FRANKS MELVILLE MEMORIAL LIBRARY	STONY BROOK	NY	11794	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	000	9	2/20/2022	NON-COMPETING CONTINUATION	$303,807
2022	2022	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	WEST 5510 FRANKS MELVILLE MEMORIAL LIBRARY	STONY BROOK	NY	11794	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	001	9	4/21/2022	NON-COMPETING CONTINUATION	$33,756
														Subtotal = $337,563

Issue Date FY: 2021 ( Subtotal = $337,563 )
2021	2021	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	WEST 5510 FRANKS MELVILLE MEMORIAL LIBRARY	STONY BROOK	NY	11794	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	000	8	2/25/2021	NON-COMPETING CONTINUATION	$337,563
														Subtotal = $337,563

Issue Date FY: 2020 ( Subtotal = $337,563 )
2020	2020	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	WEST 5510 FRANKS MELVILLE MEMORIAL LIBRARY	STONY BROOK	NY	11794	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	000	7	2/11/2020	NON-COMPETING CONTINUATION	$337,563
														Subtotal = $337,563

Issue Date FY: 2019 ( Subtotal = $313,650 )
2019	2019	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	WEST 5510 FRANKS MELVILLE MEMORIAL LIBRARY	STONY BROOK	NY	11794	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	002	6	8/30/2019	COMPETING CONTINUATION	$8,108
2019	2019	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	WEST 5510 FRANKS MELVILLE MEMORIAL LIBRARY	STONY BROOK	NY	11794	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	000	6	2/6/2019	COMPETING CONTINUATION	$313,650
2019	2018	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	WEST 5510 FRANKS MELVILLE MEMORIAL LIBRARY	STONY BROOK	NY	11794	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	001	5	8/30/2019	NON-COMPETING CONTINUATION	-$8,108
														Subtotal = $313,650

Issue Date FY: 2018 ( Subtotal = $333,685 )
2018	2018	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	WEST 5510 FRANKS MELVILLE MEMORIAL LIBRARY	STONY BROOK	NY	11794	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	000	5	2/14/2018	NON-COMPETING CONTINUATION	$300,316
2018	2018	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	WEST 5510 FRANKS MELVILLE MEMORIAL LIBRARY	STONY BROOK	NY	11794	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	001	5	4/4/2018	NON-COMPETING CONTINUATION	$33,369
														Subtotal = $333,685

Issue Date FY: 2017 ( Subtotal = $333,685 )
2017	2017	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	WEST 5510 FRANKS MELVILLE MEMORIAL LIBRARY	STONY BROOK	NY	11794	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	000	4	2/10/2017	NON-COMPETING CONTINUATION	$300,316
2017	2017	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	WEST 5510 FRANKS MELVILLE MEMORIAL LIBRARY	STONY BROOK	NY	11794	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	001	4	6/2/2017	NON-COMPETING CONTINUATION	$33,369
														Subtotal = $333,685

Issue Date FY: 2016 ( Subtotal = $333,685 )
2016	2016	SUNY, STONY BROOK	OFFICE OF RESEARCH SERVICES	STONY BROOK	NY	11794	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	000	3	2/24/2016	NON-COMPETING CONTINUATION	$333,685
														Subtotal = $333,685

Issue Date FY: 2015 ( Subtotal = $330,348 )
2015	2015	SUNY, STONY BROOK	OFFICE OF RESEARCH SERVICES	STONY BROOK	NY	11794	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	000	2	2/11/2015	NON-COMPETING CONTINUATION	$330,348
														Subtotal = $330,348

Issue Date FY: 2014 ( Subtotal = $311,100 )
2014	2014	SUNY, STONY BROOK	OFFICE OF RESEARCH SERVICES	STONY BROOK	NY	11794	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	000	1	2/18/2014	NEW	$311,100
														Subtotal = $311,100

Grand Total All Awards = $3,306,405

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Synaptic organization and plasticity of the input from the amygdala to the gustatory cortex

Award Number: R01DC013770

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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