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Resubmission of Functional approach to communication sound processing in mouse auditory cortex

Award Number: R01DC008343
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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PROJECT SUMMARY Acoustic communication is critical for normal social interactions in many species, including humans, yet so- cial aspects of communication functions and dysfunctions are often overlooked in studies of how the brain re- sponds to and learns communication sounds. One key brain mechanism concerns the neural plasticity within the auditory cortex to support learning the social meaning of new communication sounds. However, our circuit and cellular level understanding of such plasticity is more often based on studies where a sound's salience is acquired through nonsocial reinforcement procedures, rather than from rewarding social interactions. Hence, there is a gap in our knowledge of the neural principles for communication sound processing and plasticity during more realistic social auditory learning. Our long-term goal is to understand the circuit and cellular mechanisms under- lying the auditory system's encoding of socially-learned sound categories, so that causes underlying deficits in communication processing can be inferred. Our objective here is to uncover whether socially learning a sound category alters higher-order auditory cortical fields' neuronal tuning and tolerance for acoustic variability in that category's sound features. Our central hypothesis is that both Core auditory cortex and secondary auditory cor- tical field A2 are intrinsically tuned to parameters describing complex frequency trajectories of sounds, with neu- rons in a secondary field exhibiting greater tolerance in these parameters. Learning the social meaning of a specific sound category then biases neurons along a feedforward pathway through Core and A2 to become more attuned to the likely parameters of the learned category. We investigate this hypothesis by exploiting a maternal mouse model of ultrasonic communication between pups and adult females. When pup calls become behavior- ally relevant to mothers, neurons in the auditory cortex changes how they respond in ways that were not expected from nonsocial auditory learning paradigms. This proposal addresses the underlying neural mechanisms in two specific aims. First, using extracellular electrophysiology, we will determine how the neural transformation from Core to A2 alters neuronal tuning and tolerance for the acoustic features of the pup call category. Second, using a new socially-reinforced auditory training paradigm, we will determine how calibrated, explicit social experience with a novel sound category modifies the Core to A2 neural transformation. This research's significance lies in its unique ability to bridge the scientific gap between sensory and social/behavioral neuroscience in an animal model in which studies of a high level auditory function (communication) can be conducted from a systems down to a molecular level.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2022	EMORY UNIVERSITY	201 DOWMAN DR NE	ATLANTA	GA	30322	DEKALB	USA	Research Related to Deafness and Communication Disorders	000	15	4/10/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $437,165 )
2022	2022	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Research Related to Deafness and Communication Disorders	000	15	4/28/2022	NON-COMPETING CONTINUATION	$437,165
														Subtotal = $437,165

Issue Date FY: 2021 ( Subtotal = $437,165 )
2021	2021	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Research Related to Deafness and Communication Disorders	000	14	4/14/2021	NON-COMPETING CONTINUATION	$437,165
														Subtotal = $437,165

Issue Date FY: 2020 ( Subtotal = $437,165 )
2020	2020	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Research Related to Deafness and Communication Disorders	000	13	4/9/2020	NON-COMPETING CONTINUATION	$437,165
														Subtotal = $437,165

Issue Date FY: 2019 ( Subtotal = $437,165 )
2019	2019	EMORY UNIVERSITY	1599 CLIFTON RD.	ATLANTA	GA	30322	DEKALB	USA	Research Related to Deafness and Communication Disorders	000	12	4/16/2019	NON-COMPETING CONTINUATION	$437,165
														Subtotal = $437,165

Issue Date FY: 2018 ( Subtotal = $437,165 )
2018	2018	EMORY UNIVERSITY	1599 CLIFTON RD.	ATLANTA	GA	30322	DEKALB	USA	Research Related to Deafness and Communication Disorders	003	11	9/10/2018	COMPETING CONTINUATION	$2,708
2018	2018	EMORY UNIVERSITY	1599 CLIFTON RD.	ATLANTA	GA	30322	DEKALB	USA	Research Related to Deafness and Communication Disorders	001	11	4/11/2018	COMPETING CONTINUATION	$437,165
2018	2015	EMORY UNIVERSITY	1599 CLIFTON RD.	ATLANTA	GA	30322	DEKALB	USA	Research Related to Deafness and Communication Disorders	002	10	9/10/2018	NON-COMPETING CONTINUATION	-$2,708
2018	2015	EMORY UNIVERSITY	1599 CLIFTON RD.	ATLANTA	GA	30322	DEKALB	USA	Research Related to Deafness and Communication Disorders	000	10	4/11/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $437,165

Issue Date FY: 2017 ( Subtotal = $0 )
2017	2015	EMORY UNIVERSITY	1599 CLIFTON RD.	ATLANTA	GA	30322	DEKALB	USA	Research Related to Deafness and Communication Disorders	000	10	6/2/2017	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2015 ( Subtotal = $310,046 )
2015	2015	EMORY UNIVERSITY	1784 N DECATUR RD,S 530 NDBLDG	ATLANTA	GA	30322	DEKALB	USA	Research Related to Deafness and Communication Disorders	000	10	7/27/2015	NON-COMPETING CONTINUATION	$310,046
														Subtotal = $310,046

Issue Date FY: 2014 ( Subtotal = $345,664 )
2014	2014	EMORY UNIVERSITY	1784 N DECATUR RD,S 530 NDBLDG	ATLANTA	GA	30322	DEKALB	USA	Research Related to Deafness and Communication Disorders	000	9	8/4/2014	NON-COMPETING CONTINUATION	$345,664
														Subtotal = $345,664

Issue Date FY: 2013 ( Subtotal = $346,284 )
2013	2013	EMORY UNIVERSITY	1784 N DECATUR RD,S 530 NDBLDG	ATLANTA	GA	30322	DEKALB	USA	Research Related to Deafness and Communication Disorders	000	8	7/25/2013	NON-COMPETING CONTINUATION	$346,284
														Subtotal = $346,284

Issue Date FY: 2012 ( Subtotal = $401,088 )
2012	2012	EMORY UNIVERSITY	1784 N DECATUR RD,S 530 NDBLDG	ATLANTA	GA	30322	DEKALB	USA	Research Related to Deafness and Communication Disorders	001	7	8/2/2012	NON-COMPETING CONTINUATION	$366,027
2012	2012	EMORY UNIVERSITY	1784 N DECATUR RD,S 530 NDBLDG	ATLANTA	GA	30322	DEKALB	USA	Research Related to Deafness and Communication Disorders	000	6	3/27/2012	SUPPLEMENT FOR EXPANSION	$35,061
														Subtotal = $401,088

Issue Date FY: 2011 ( Subtotal = $327,756 )
2011	2011	EMORY UNIVERSITY	1784 N DECATUR RD,S 530 NDBLDG	ATLANTA	GA	30322	DEKALB	USA	Research Related to Deafness and Communication Disorders	001	6	9/21/2011	COMPETING CONTINUATION	$327,756
2011	2010	EMORY UNIVERSITY	1784 N DECATUR RD,S 530 NDBLDG	ATLANTA	GA	30322	DEKALB	USA	Research Related to Deafness and Communication Disorders	000	5	9/19/2011	NON-COMPETING CONTINUATION	$0
														Subtotal = $327,756

Issue Date FY: 2010 ( Subtotal = $254,040 )
2010	2010	EMORY UNIVERSITY	1784 N DECATUR RD,S 530 NDBLDG	ATLANTA	GA	30322	DEKALB	USA	Research Related to Deafness and Communication Disorders	000	5	5/20/2010	NON-COMPETING CONTINUATION	$254,040
														Subtotal = $254,040

Issue Date FY: 2009 ( Subtotal = $392,230 )
2009	2009	EMORY UNIVERSITY	1784 N DECATUR RD,S 530 NDBLDG	ATLANTA	GA	30322	DEKALB	USA	Trans-NIH Recovery Act Research Support	000	3	7/15/2009	SUPPLEMENT FOR EXPANSION	$135,625
2009	2009	EMORY UNIVERSITY	1784 N DECATUR RD,S 530 NDBLDG	ATLANTA	GA	30322	DEKALB	USA	Research Related to Deafness and Communication Disorders	001	4	6/5/2009	NON-COMPETING CONTINUATION	$256,605
														Subtotal = $392,230

Issue Date FY: 2008 ( Subtotal = $339,108 )
2008	2008	EMORY UNIVERSITY	1784 N DECATUR RD,S 530 NDBLDG	ATLANTA	GA	30322	DEKALB	USA	Research Related to Deafness and Communication Disorders	000	3	5/27/2008	NON-COMPETING CONTINUATION	$339,108
														Subtotal = $339,108

Issue Date FY: 2007 ( Subtotal = $329,658 )
2007	2007	EMORY UNIVERSITY	1784 N DECATUR RD,S 530 NDBLDG	ATLANTA	GA	30322	DEKALB	USA	Research Related to Deafness and Communication Disorders	000	2	5/9/2007	NON-COMPETING CONTINUATION	$259,985
2007	2007	EMORY UNIVERSITY	1784 N DECATUR RD,S 530 NDBLDG	ATLANTA	GA	30322	DEKALB	USA	Research Related to Deafness and Communication Disorders	001	2	7/23/2007	SUPPLEMENT FOR EXPANSION	$69,673
														Subtotal = $329,658

Issue Date FY: 2006 ( Subtotal = $292,750 )
2006	2006	EMORY UNIVERSITY	1784 N DECATUR RD,S 530 NDBLDG	ATLANTA	GA	30322	DEKALB	USA	Research Related to Deafness and Communication Disorders	000	1	6/16/2006	NEW	$292,750
														Subtotal = $292,750

Grand Total All Awards = $5,524,449

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Resubmission of Functional approach to communication sound processing in mouse auditory cortex

Award Number: R01DC008343

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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