Friday, April 19, 2024 4/19/2024

Mechanisms of SynCAM-Induced Synapse Formation

Award Number: R01DA018928
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Group Awards By Issue Date FY or Funding FY:

View Award Abstract

PROJECT SUMMARY Synapses are highly organized cellular structures that underlie neuronal communication. The formation of synapses is promoted by trans-synaptic interactions, and the adhesive complexes spanning the cleft are now understood to have instructive roles during synapse development. Our recent progress has shown that the immunoglobulin adhesion protein SynCAM 1 induces and maintains excitatory synapses, and that it contributes to shaping the synaptic cleft. The long-term goal of our research program is to define how trans- synaptic interactions organize synapse formation and maturation. The central hypothesis underlying the research proposed in this application is that synaptic adhesion molecules engage select signaling pathways to control presynaptic assembly and postsynaptic maturation, and dynamically remodel the synaptic connectivity of mature neurons in an activity-dependent manner. Three specific aims will be pursued to test this hypothesis. First, the presynaptic scaffolding and postsynaptic signaling mechanisms of SynCAM 1 will be defined. A combination of molecular and imaging approaches will be used to analyze a novel presynaptic partner, and characterize the postsynaptic regulation of small GTPases downstream of SynCAM 1. Second, the surface dynamics and activity-dependent properties of synaptic adhesion proteins will be probed. This aim employs live single particle tracking of adhesion proteins on the surface of cultured neurons. Third, it will be analyzed how synapse-organizing proteins promote synaptic connectivity during learning. We will address this question in a transgenic mouse model that allows manipulating synaptogenesis in a neuron-select manner during memory processes. These aims are significant because they determine how trans-synaptic interactions engage pre- and post-synaptic mechanisms to guide synapse development, and how these synapse-organizing complexes remodel synapses and control neuronal wiring. By establishing these fundamental aspects of synaptic biology, this research defines on molecular and in vivo levels how synaptogenic adhesion proteins control synapse formation and remodeling, enabling us to understand disorder-linked aberrations.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2021	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	NEW HAVEN	USA	Drug Abuse and Addiction Research Programs	000	17	1/8/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2021	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	NEW HAVEN	USA	Drug Abuse and Addiction Research Programs	000	17	12/15/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $346,152 )
2021	2021	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	NEW HAVEN	USA	Drug Abuse and Addiction Research Programs	003	17	2/19/2021	NON-COMPETING CONTINUATION	$34,616
2021	2021	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	NEW HAVEN	USA	Drug Abuse and Addiction Research Programs	002	17	11/20/2020	NON-COMPETING CONTINUATION	$311,536
2021	2020	TRUSTEES OF TUFTS COLLEGE	136 HARRISON AVE	BOSTON	MA	02111	SUFFOLK	USA	Drug Abuse and Addiction Research Programs	000	15	11/5/2020	NON-COMPETING CONTINUATION	-$36,856
2021	2020	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	NEW HAVEN	USA	Drug Abuse and Addiction Research Programs	001	16	11/5/2020	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$36,856
														Subtotal = $346,152

Issue Date FY: 2020 ( Subtotal = $338,816 )
2020	2020	TRUSTEES OF TUFTS COLLEGE	136 HARRISON AVE	BOSTON	MA	02111	SUFFOLK	USA	Drug Abuse and Addiction Research Programs	000	15	11/26/2019	NON-COMPETING CONTINUATION	$306,887
2020	2020	TRUSTEES OF TUFTS COLLEGE	136 HARRISON AVE	BOSTON	MA	02111	SUFFOLK	USA	Drug Abuse and Addiction Research Programs	002	15	7/15/2020	NON-COMPETING CONTINUATION	-$231,000
2020	2020	TRUSTEES OF TUFTS COLLEGE	136 HARRISON AVE	BOSTON	MA	02111	SUFFOLK	USA	Drug Abuse and Addiction Research Programs	001	15	2/11/2020	NON-COMPETING CONTINUATION	$34,099
2020	2020	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	NEW HAVEN	USA	Drug Abuse and Addiction Research Programs	003	16	7/15/2020	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$228,830
														Subtotal = $338,816

Issue Date FY: 2019 ( Subtotal = $340,986 )
2019	2019	TRUSTEES OF TUFTS COLLEGE	136 HARRISON AVE	BOSTON	MA	02111	SUFFOLK	USA	Drug Abuse and Addiction Research Programs	000	14	11/28/2018	NON-COMPETING CONTINUATION	$340,986
														Subtotal = $340,986

Issue Date FY: 2018 ( Subtotal = $340,986 )
2018	2018	TRUSTEES OF TUFTS COLLEGE	136 HARRISON AVE	BOSTON	MA	02111	SUFFOLK	USA	Drug Abuse and Addiction Research Programs	001	13	4/26/2018	NON-COMPETING CONTINUATION	$34,098
2018	2018	TRUSTEES OF TUFTS COLLEGE	136 HARRISON AVE	BOSTON	MA	02111	SUFFOLK	USA	Drug Abuse and Addiction Research Programs	000	13	11/20/2017	NON-COMPETING CONTINUATION	$306,888
														Subtotal = $340,986

Issue Date FY: 2017 ( Subtotal = $340,986 )
2017	2017	TRUSTEES OF TUFTS COLLEGE	136 HARRISON AVE	BOSTON	MA	02111	SUFFOLK	USA	Drug Abuse and Addiction Research Programs	001	12	1/26/2017	COMPETING CONTINUATION	$340,986
2017	2015	TRUSTEES OF TUFTS COLLEGE	136 HARRISON AVE	BOSTON	MA	02111	SUFFOLK	USA	Drug Abuse and Addiction Research Programs	000	11	1/26/2017	NON-COMPETING CONTINUATION	$0
2017	2015	TRUSTEES OF TUFTS COLLEGE	136 HARRISON AVE	BOSTON	MA	02111	SUFFOLK	USA	Drug Abuse and Addiction Research Programs	002	11	7/13/2017	NON-COMPETING CONTINUATION	$0
														Subtotal = $340,986

Issue Date FY: 2015 ( Subtotal = $292,545 )
2015	2015	TUFTS UNIVERSITY	169 HOLLAND ST, 2ND FLOOR	SOMERVILLE	MA	02144	MIDDLESEX	USA	Drug Abuse and Addiction Research Programs	000	11	2/18/2015	NON-COMPETING CONTINUATION	$292,545
														Subtotal = $292,545

Issue Date FY: 2014 ( Subtotal = $297,001 )
2014	2014	TUFTS UNIVERSITY	169 HOLLAND ST, 2ND FLOOR	SOMERVILLE	MA	02144	MIDDLESEX	USA	Drug Abuse and Addiction Research Programs	002	10	2/18/2014	NON-COMPETING CONTINUATION	$297,000
2014	2013	TUFTS UNIVERSITY	169 HOLLAND ST, 2ND FLOOR	SOMERVILLE	MA	02144	MIDDLESEX	USA	Drug Abuse and Addiction Research Programs	004	9	3/7/2014	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	-$4,762
2014	2013	TUFTS UNIVERSITY	169 HOLLAND ST, 2ND FLOOR	SOMERVILLE	MA	02144	MIDDLESEX	USA	Drug Abuse and Addiction Research Programs	001	9	1/21/2014	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$25,869
2014	2013	YALE UNIVERSITY	47 College Street	NEW HAVEN	CT	06520	NEW HAVEN	USA	Drug Abuse and Addiction Research Programs	003	8	3/7/2014	NON-COMPETING CONTINUATION	-$21,107
2014	2013	YALE UNIVERSITY	47 College Street	NEW HAVEN	CT	06520	NEW HAVEN	USA	Drug Abuse and Addiction Research Programs	005	8	3/12/2014	NON-COMPETING CONTINUATION	$21,107
2014	2013	YALE UNIVERSITY	47 College Street	NEW HAVEN	CT	06520	NEW HAVEN	USA	Drug Abuse and Addiction Research Programs	006	8	3/14/2014	NON-COMPETING CONTINUATION	$4,763
2014	2013	YALE UNIVERSITY	47 College Street	NEW HAVEN	CT	06520	NEW HAVEN	USA	Drug Abuse and Addiction Research Programs	000	8	1/21/2014	NON-COMPETING CONTINUATION	-$25,869
														Subtotal = $297,001

Issue Date FY: 2013 ( Subtotal = $287,084 )
2013	2013	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	NEW HAVEN	USA	Drug Abuse and Addiction Research Programs	007	8	3/14/2014	NON-COMPETING CONTINUATION	$4,763
2013	2013	TUFTS UNIVERSITY	169 HOLLAND ST, 2ND FLOOR	SOMERVILLE	MA	02144	MIDDLESEX	USA	Drug Abuse and Addiction Research Programs	004	9	3/7/2014	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	-$4,762
2013	2013	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	NEW HAVEN	USA	Drug Abuse and Addiction Research Programs	000	8	4/19/2013	NON-COMPETING CONTINUATION	$269,141
2013	2013	TUFTS UNIVERSITY	169 HOLLAND ST, 2ND FLOOR	SOMERVILLE	MA	02144	MIDDLESEX	USA	Drug Abuse and Addiction Research Programs	003	9	1/21/2014	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$25,869
2013	2013	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	NEW HAVEN	USA	Drug Abuse and Addiction Research Programs	005	8	3/7/2014	NON-COMPETING CONTINUATION	-$21,107
2013	2013	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	NEW HAVEN	USA	Drug Abuse and Addiction Research Programs	002	8	1/21/2014	NON-COMPETING CONTINUATION	-$25,869
2013	2013	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	NEW HAVEN	USA	Drug Abuse and Addiction Research Programs	006	8	3/12/2014	NON-COMPETING CONTINUATION	$21,107
2013	2013	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	NEW HAVEN	USA	Drug Abuse and Addiction Research Programs	001	8	5/16/2013	NON-COMPETING CONTINUATION	$17,942
														Subtotal = $287,084

Issue Date FY: 2012 ( Subtotal = $298,500 )
2012	2012	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	NEW HAVEN	USA	Drug Abuse and Addiction Research Programs	000	7	2/27/2012	NON-COMPETING CONTINUATION	$298,500
														Subtotal = $298,500

Issue Date FY: 2011 ( Subtotal = $321,470 )
2011	2011	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	NEW HAVEN	USA	Drug Abuse and Addiction Research Programs	002	6	3/14/2011	COMPETING CONTINUATION	$0
2011	2011	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	NEW HAVEN	USA	Drug Abuse and Addiction Research Programs	003	6	9/13/2011	SUPPLEMENT FOR EXPANSION	$70,000
2011	2011	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	NEW HAVEN	USA	Drug Abuse and Addiction Research Programs	000	6	2/28/2011	COMPETING CONTINUATION	$251,470
2011	2011	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	NEW HAVEN	USA	Drug Abuse and Addiction Research Programs	001	6	3/7/2011	COMPETING CONTINUATION	$0
														Subtotal = $321,470

Issue Date FY: 2009 ( Subtotal = $256,941 ) (Continued on the next page)
Grand Total All Awards = $4,589,197

Page 1 of 2 (59 items)12

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Mechanisms of SynCAM-Induced Synapse Formation

Award Number: R01DA018928

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer